An approach to the treatment of bacterial vaginosis using a bacteriophage cocktail
https://doi.org/10.31549/2542-1174-2023-7-4-113-123
Abstract
I n t r o d u c t i o n . A variety of treatment regimens for bacterial vaginosis (BV) pose to the clinician the question of choosing appropriate therapy for this disease.
A i m . Improving the results of combination treatment of reproductive-age women with bacterial vaginosis by topical application of polyvalent bacteriophages.
M a t e r i a l s a n d m e t h o d s . A prospective study involving 120 female patients from 18 to 45 years old with complaints of abnormal vaginal discharge, diagnosis of BV confirmed by the Amsel criteria was performed. The patients were divided into 4 groups of 30 people, depending on the treatment regimen for BV: group 1 – metronidazole (gel) intravaginally + preparation Phagogyn (gel), polyvalent bacteriophage (PVB) for topical application; group 2 – clindamycin (cream) intravaginally + Phagogyn for topical application; group 3 – chlorhexidine gluconate (vaginal tablets) + Phagogyn for topical application; group 4 – Elzhina (ornidazole 500 mg, neomycin 65 000 U, prednisolone 3 mg, econazole 100 mg) + Phagogyn for topical application.
R e s u l t s . 10–14 days after the treatment, the effectiveness of metronidazole for vaginal application in combination with Phagogyn according to the Amsel criteria was 60.00%, clindamycin intravaginally in combination with Phagogyn – 73.33%, chlorhexidine gluconate intravaginally with Phagogyn – 43.33%, Elzhina + Phagogyn – 96.67%.
C o n c l u s i o n . The combination of Elzhina with Phagogyn is feasible for use in clinical practice to achieve better results in the treatment of BV, since this combination turned out to be the most effective.
About the Authors
U. V. Piletskaya
Novosibirsk State Medical University
Russian Federation
Russian Federation
Ulyana V. Piletskaya – Assistant, Department of Obstetrics and Gynecology
52, Krasny prosp., Novosibirsk, 630091
I. O. Marinkin
Novosibirsk State Medical University
Russian Federation
Russian Federation
Igor O. Marinkin – Dr. Sci. (Med.), Professor, Head, Department of Obstetrics and Gynecology
Novosibirsk
K. Yu. Makarov
Novosibirsk State Medical University
Russian Federation
Russian Federation
Konstantin Yu. Makarov – Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology
Novosibirsk
T. M. Sokolova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Tatyana M. Sokolova – Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology
Novosibirsk
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For citations:
Piletskaya U.V., Marinkin I.O., Makarov K.Yu., Sokolova T.M. An approach to the treatment of bacterial vaginosis using a bacteriophage cocktail. Journal of Siberian Medical Sciences. 2023;(4):113-123. (In Russ.) https://doi.org/10.31549/2542-1174-2023-7-4-113-123
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