Listeriosis as a cause of antenatal fetal death
https://doi.org/10.31549/2542-1174-2025-9-4-145-155
Abstract
Listeria (L.) monocytogenes is a Gram-positive facultative intracellular pathogen that can cause severe infections through consumption of contaminated food. The risk of developing and poor outcomes of listeriosis in pregnant women is higher than in the general population. The course and outcome of the disease are influenced not only by the host’s immune status but also by the genetic variant of L. monocytogenes and an infective dose. This article presents a brief review of the literature on listeriosis in pregnant women and a clinical case of fetal death associated with a full-blown listeriosis infection in a woman in the second trimester of pregnancy. The patient’s clinical manifestations and management are described. Symptoms of L. monocytogenes infection during pregnancy were nonspecific. Laboratory findings confirmed the infectious origin of the obstetric pathology and the severity of the infection.
About the Authors
L. V. Puzyreva
Omsk State Medical University
Russian Federation
Russian Federation
Larisa V. Puzyreva – Dr. Sci. (Med.), Associate Professor, Head, Department of Pediatric Infectious Diseases
12, Lenina str., Omsk, 644099
L. L. Shkabarnya
Regional Clinical Hospital
Russian Federation
Russian Federation
Lyudmila L. Shkabarnya – Obstetrician-gynecologist, Head, Gynecology Department, Regional Perinatal Center
Omsk
T. D. Polyakova
Central District Hospital
Russian Federation
Russian Federation
Tatyana D. Polyakova – Infectious Disease Specialist
Omsk region, Gorkovskoye, worker’s settlement
E. A. Gashina
Omsk State Medical University
Russian Federation
Russian Federation
Elena A. Gashina – Cand. Sci. (Med.), Associate Professor, Department of Pediatric Infectious Diseases
Omsk
E. F. Lobova
Omsk State Medical University
Russian Federation
Russian Federation
Elena F. Lobova – Cand. Sci. (Med.), Associate Professor, Department of Pediatric Infectious Diseases
Omsk
References
1. Kladova O.V., Andzhel A.E., Kompaniets Yu.V., Grishkevich N.L. To the issue of differential diagnosis of listeriosis. Children Infections. 2019;18(3):61-66. DOI: 10.22627/2072-8107-2019-18-3-61-66. (In Russ.)
2. Koopmans M.M., Brouwer M.C., Vázquez-Boland J.A., van de Beek D. Human listeriosis. Clin. Microbiol Rev. 2023;36(1):e0006019. DOI:10.1128/cmr.00060-19.
3. Belova A.V., Nikonov А.P., Kaptilnyy V.A., Naumenko N.S. Lysteriosis and pregnancy: actual issues of diagnostics, treatment and prevention. V.F. Snegirev Archives of Obstetrics and Gynecology. 2018;5(4):187-192. DOI: 10.18821/2313-8726-2018-5-4-187-192. (In Russ.)
4. Dunphy L., Polkampali M., Simmons W., Fowler G. Maternal sepsis caused by Listeria monocytogenes with a fatal fetal outcome. BMJ Case Rep. 2022;15(10):e249989. DOI:10.1136/bcr-2022-249989.
5. Moura A., Criscuolo A., Pouseele H. et al. Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes. Nat. Microbiol. 2016;10(2):16185. DOI: 10.1038/nmicrobiol.2016.185.
6. Maury M.M., Bracq-Dieye H., Huang L. et al. Hypervirulent Listeria monocytogenes clones’ adaption to mammalian gut accounts for their association with dairy products. Nat. Commun. 2019;10(1):2488. DOI: 10.1038/s41467-019-10380-0.
7. Maury M.M., Tsai Y.H., Charlier C. et al. Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nat. Genet. 2016;48(3):308-313. DOI: 10.1038/ng.3501.
8. Kalinin E.V., Chalenko Y.M., Sysolyatina E.V. et al. Bacterial hepatocyte growth factor receptor agonist stimulates hepatocyte proliferation and accelerates liver regeneration in a partial hepatectomy rat model. Drug Develop. Res. 2021;82(1):123-132. DOI: 10.1002/ddr.21737.
9. Kalinin E., Chalenko Y., Kezimana P. et al. Combination of growth conditions and InlB-specifi c dot-immunoassay for rapid detection of Listeria monocytogenes in raw milk. J. Dairy Sci. 2023;106(3):1638-1649. DOI: 10.3168/jds.2022-21997.
10. Chalenko Y., Kalinin E., Marchenkov V. et al. Phylogenetically defi ned isoforms of Listeria monocytogenes invasion factor InlB diff erently activate intracellular signaling pathways and interact with the receptor gC1q-R. Int. J. Mol. Sci. 2019;20(17):4138. DOI: 10.3390/ijms20174138.
11. Chalenko Y., Sobyanin K., Sysolyatina E. et al. Hepatoprotective activity of InlB321/15, the HGFR ligand of bacterial origin, in CCI4-induced acute liver injury mice. Biomedicines. 2019;7(2):29. DOI: 10.3390/biomedicines7020029.
12. Fan Z., Xie J., Li Y., Wang H. Listeriosis in mainland China: A systematic review. Int. J. Infect. Dis. 2019;81:17-24. DOI: 10.1016/j.ijid.2019.01.007.
13. Perez-Trallero E., Zigorraga C., Artieda J. et al. Two outbreaks of Listeria monocytogenes infection, Northern Spain. Emerg. Infect. Dis. 2014;20(12):2155-2157. DOI: 10.3201/eid2012.140993
14. Cavalcanti A.A.C., Limeira C.H., Siqueira I.N. et al. The prevalence of Listeria monocytogenes in meat products in Brazil: A systematic literature review and meta-analysis. Res. Vet. Sci. 2022;145:169-176. DOI: 10.1016/j.rvsc.2022.02.015.
15. Kalinin Е.V., Chalenko Ya.M., Safarova P.V. et al. Analysis of production levels of InlA and InlB invasion factors in Listeria monocytogenes isolates collected in the Russian Federation. Journal of Microbiology, Epidemiology and Immunobiology. 2023;100(5):276-286. DOI: 10.36233/0372-9311-397. (In Russ.)
16. Tyukavkina S.Yu., Kotieva I.M., Dodokhova M.A. et al. Pathogenesis and clinical forms of human listeriosis. South Russian Journal of Therapeutic Practice. 2024;5(1):99-111. DOI: 10.21886/2712-8156-2024-5-1-99-111. (In Russ.)
17. Charlier C., Perrodeau É., Leclercq A. et al. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. Lancet Infect. Dis. 2017;17(5):510-519. DOI: 10.1016/S1473-3099(16)30521-7.
18. Elinav H., Hershko-Klement A., Valinsky L. et al. Israeli Listeria Study Group. Pregnancy-associated listeriosis: clinical characteristics and geospatial analysis of a 10-year period in Israel. Clin. Infect. Dis.2014;59(7):953-961. DOI: 10.1093/cid/ciu504.
19. National Institute for communicable diseases. Listeriosis update. 2018. URL: www.nicd.ac.za/listeriosis_update/ (accessed: 22.10.2025).
20. Charlier C., Disson O., Lecuit M. Maternal-neonatal listeriosis. Virulence. 2020;11(1):391-397. DOI: 10.1080/21505594.2020.1759287.
21. Wolfe B., Wiepz G.J., Schotzko M. et al. Acute fetal demise with fi rst trimester maternal infection resulting from Listeria monocytogenes in a nonhuman primate model. mBio. 2017;8:e01938-16. DOI: 10.1128/mBio.01938-16.
22. Arck P.C., Hecher K. Fetomaternal immune cross-talk and its consequences for maternal and off spring’s health. Nat. Med. 2013;19:548-556. DOI: 10.1038/nm.3160.
23. Prevention of listeriosis in humans. Sanitary and epidemiological rules. SP 3.1.7.2817-10 (approved by Resolution No. 186 of the Chief State Sanitary Doctor of the Russian Federation dated December 29, 2010)). URL: https://normativ.kontur.ru/document?moduleId=9&documentId=175718 (accessed 22.10.2025).
Review
For citations:
Puzyreva L.V., Shkabarnya L.L., Polyakova T.D., Gashina E.A., Lobova E.F. Listeriosis as a cause of antenatal fetal death. Journal of Siberian Medical Sciences. 2025;(4):145-155. https://doi.org/10.31549/2542-1174-2025-9-4-145-155
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