TRANSFORMING BETA GROWTH FACTOR AND SOME CYITOKINEA IN VITREOUS BODY OF PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY
Abstract
Samples of vitreous body at patients with proliferative diabetic retinopathy (PDR) were investigated. The data obtained in research testify to existence of violations of cytokines regulation which is shown in activation of local immunoinflammatory process (reliable increase of concentration of IL-17A, IL-8, IL-6, MHF-1). It is established that not only a factor of growth of vessels endothelium, but also TGF-β2, and IL-4 possessing proliferative and fibroplastic activity are involved in processes of proliferation at PDR. The reliable increase revealed in research in vitreous body at patients with PDR of MHF-1 protein allows to make the assumption of its participation in mechanisms of vascular proliferation at the studied pathological process.
About the Authors
D. V. Chernykh
Novosibirsk branch FSBE «Intersectoral Scientific and Technical Complex „Eye Microsurgery“ n. a. the academician S. N. Fedorov» of Ministry of Health
Russian Federation
Russian Federation
O. M. Gorbenko
FSBE «Research center of clinical and experimental medicine SB RAMS»
Russian Federation
Russian Federation
A. P. Shvayuk
FSBE «Research center of clinical and experimental medicine SB RAMS»
Russian Federation
Russian Federation
O. O. Obukhova
FSBE «Research center of clinical and experimental medicine SB RAMS»
Russian Federation
Russian Federation
V. V. Chernykh
Novosibirsk branch FSBE «Intersectoral Scientific and Technical Complex „Eye Microsurgery“ n. a. the academician S. N. Fedorov» of Ministry of Health
Russian Federation
Russian Federation
A. N. Trunov
Novosibirsk branch FSBE «Intersectoral Scientific and Technical Complex „Eye Microsurgery“ n. a. the academician S. N. Fedorov» of Ministry of Health; FSBE «Research center of clinical and experimental medicine SB RAMS»
Russian Federation
Russian Federation
References
1. Иммунологический контроль при хирургическом лечении больных с пролиферативной диабетической ретинопатией с предварительным интраветриальным введением Луцентиса / О. С. Слепова, В. В. Нероев, П. А. Илюхин, О. И. Сарыгина // Рос. офтальмол. журн. - 2012. - № 1. - С. 69-74.
2. Влияние эфферентных и лимфотропных технологий на течение патологического процесса при диабетической ретинопатии / В. В. Черных, А. Г. Лысиков, В. И. Братко, А. Н. Трунов // Офтальмохирургия. - 2008. - № 3. - С. 4-7.
3. Активность местного воспалительного и пролиферативного процесса в патогенезе диабетической ретинопатии / В. В. Черных, Е. В. Варваринский, О. М. Горбенко [и др.] // Бюл. СО РАМН. - 2013. - Т. 33, № 5. - С. 60-64.
4. Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy / M. Citirik, E. U. Kabatas, C. Batman [et al.] // Ophthalmic Res. - 2012. - Vol. 47, N 1. - P. 7-12.
5. Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1 / V. Goede, L. Brogelli, M. Ziche, H. G. Augustin // Int. J. Cancer. - 1999. - Vol. 82, N 5. - P. 765-770.
6. A pro-fibrotic role for interleukin-4 in cardiac pressure overload / P. Kanellakis, M. Ditiatkovski, G. Kostolias, A. Bobik // Cardiovasc. Res. - 2012. - Vol. 95, N 1. - P. 77-85.
7. Interleukin-17 in various ocular surface inflammatory diseases / M. H. Kang, M. K. Kim, H. J. Lee [et al.] // J. Korean Med. Sci. - 2011. - Vol. 26, N 7. - P. 938-944.
8. Kowluru R. A. Metabolic memory and diabetic retinopathy : role of inflammatory mediators in retinal pericytes / R. A. Kowluru, Q. Zhong, M. Kanwar // Exp. Eye Res. - 2010. - Vol. 90, N 5. - P. 617-623.
9. Neurath M. F. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer / M. F. Neurath, S. Finotto // Cytokine Growth Factor Rev. - 2011. - Vol. 22, N 2. - P. 83-89.
10. Imbalanced levels of angiogenic and angiostatic factors in vitreous, plasma and postmortem retinal tissue of patients with proliferative diabetic retinopathy / N. Mohan, F. Monickaraj, M. Balasubramanyam [et al.] // J. Diabetes Complications. - 2012. - Vol. 26, N 5. - P. 435-441.
11. Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales’ disease / P. Murugeswari, D. Shukla, A. Rajendran [et al.] // Retina. - 2008. - Vol. 28, N 6. - P. 817-824.
12. Pennock S. Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses / S. Pennock, A. Kazlauskas // Mol. Cell Biol. - 2012. - Vol. 32, N 10. - P. 1955-1966.
13. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4 / A. E. Postlethwaite, M. A. Holness, H. Katai, R. Raghow // J. Clin. Invest. - 1992. - Vol. 90, N 4. - P. 1479-1485.
14. Characterization of cytokines associated with Th17 cells in the eyes of horses with recurrent uveitis / D. P. Regan, M. C. Aarnio, W. S. Davis [et al.] // Vet. Ophtalmol. - 2012. - Vol. 15, N 3. - P. 145-152.
15. Human endothelial cells express CCR2 and respond to MCP-1 : direct role of MCP-1 in angiogenesis and tumor progression / R. Salcedo, M. L. Ponce, H. A. Young [et al.] // Blood. - 2000. - Vol. 96, N 1. - P. 34-40.
16. Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion / Y. Suzuki, M. Nakazawa, K. Suzuki [et al.] // Jpn. J. Ophthalmol. - 2011. - Vol. 55, N 3. - P. 256-263.
17. Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy / C. Symeonidis, E. Papakonstantinou, S. Androudi [et al.] // Cytokine. - 2011. - Vol. 54, N 2. - P. 212-217.
18. Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy / Y. Wakabayashi, Y. Usui, Y. Okunuki [et al.] // Retina. - 2010. - Vol. 30, N 2. - P. 339-344.
19. Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy / Y. Wakabayashi, Y. Usui, Y. Okunuki [et al.] // Retina. - 2011. - Vol. 31, N 9. - P. 1951-1957.
20. Intraocular VEGF level as a risk factor for postoperative complications after vitrectomy for proliferative diabetic retinopathy / Y. Wakabayashi, Y. Usui, Y. Okunuki [et al.] // Invest. Ophthalmol. Vis. Sci. - 2012. - Vol. 53, N 10. - P. 6403-6410.
21. Zorena K. Relationship between serum transforming growth factor β1 concentrations and the duration of type 1 diabetes mellitus in children and adolescents / K. Zorena, D. Raczy?ska, P. Wi?niewski // Mediators Inflamm. - 2013. - URL : http://www.hindawi.com/journals/mi/2013/849457/
Review
For citations:
Chernykh D.V., Gorbenko O.M., Shvayuk A.P., Obukhova O.O., Chernykh V.V., Trunov A.N. TRANSFORMING BETA GROWTH FACTOR AND SOME CYITOKINEA IN VITREOUS BODY OF PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY. Journal of Siberian Medical Sciences. 2015;(1):31.
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