INFLUENCE OF STANDARD PATHOGENETIC THERAPY ON THE SERUMAL LEVEL OF MOLECULES OF ADHESION OF SCD50, SCD54 AT PATIENTS WITH ADMIXED BRONCHIAL ASTHMA

Abstract

The purpose of the presented research is determination of serumal concentration of molecules of adhesion (sCD54, sCD50) and an assessment of influence on it of standard therapy at patients with the admixed bronchial asthma (BA). In the conditions of pulmonary unit examination of 50 patients with BA of the admixed genesis of an uncontrollable course in an exacerbation stage is conducted. Illness duration at the examined patients was from 1 year to 40 years. BA of moderate severity was diagnosed at 25 (50 %) patients, at the others serious disease is revealed. Increase of the maintenance of soluble molecules of adhesion is revealed (sCD54 and sCD50) at a severe BA of the admixed genesis. Existence of correlation dependence of the tested soluble molecules with functional indicators of lungs and inflammatory changes of a peripheric blood allowed to consider high serumal concentration of sCD54 and sCD50 markers of severe admixed BA at adults. Treatment of BA exacerbation with combined usage of systemic and inhalation glucocorticosteroids along with antibiotic therapy leads to normalization of the increased serumal level of sCD54, sCD50.