EVALUATING CYTOTOXICITY AND APYROGENICITY OF A BIODEGRADABLE POLYLACTIDE MATRIX
Abstract
The article examines the biological safety of a biodegradable matrix with specified physical and chemical properties fabricated from the polylactic acid by aerodynamic spinning and extrusion in the turbulent gas flow. Via a comparative analysis of the viability of rat bone marrow cells in vitro , we have determined that the studied synthetic polylactide matrix lacks cytotoxicity. According to the test results, the studied material proved to be apyrogenic.
About the Authors
K. V. Zaytsev
State Budgetary Institution «The Siberian Federal Research Clinical Center under the Federal Medical Biological Agency»
Russian Federation
Russian Federation
O. B. Zhukova
State Budgetary Institution «The Siberian Federal Research Clinical Center under the Federal Medical Biological Agency»
Russian Federation
Russian Federation
I. A. Khlusov
State Budgetary Institution «The Siberian Federal Research Clinical Center under the Federal Medical Biological Agency»
Russian Federation
Russian Federation
A. A. Gostyukhina
State Budgetary Institution «The Siberian Federal Research Clinical Center under the Federal Medical Biological Agency»
Russian Federation
Russian Federation
N. G. Abdulkina
State Budgetary Institution «The Siberian Federal Research Clinical Center under the Federal Medical Biological Agency»
Russian Federation
Russian Federation
S. I. Tverdokhlebov
State Budgetary Institution «The Siberian Federal Research Clinical Center under the Federal Medical Biological Agency»
Russian Federation
Russian Federation
N. P. Stepanenko
State Budgetary Institution «The Siberian Federal Research Clinical Center under the Federal Medical Biological Agency»
Russian Federation
Russian Federation
A. A. Zaytsev
State Budgetary Institution «The Siberian Federal Research Clinical Center under the Federal Medical Biological Agency»
Russian Federation
Russian Federation
V. A. Vorobyev
State Budgetary Institution «The Siberian Federal Research Clinical Center under the Federal Medical Biological Agency»
Russian Federation
Russian Federation
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Review
For citations:
Zaytsev K.V., Zhukova O.B., Khlusov I.A., Gostyukhina A.A., Abdulkina N.G., Tverdokhlebov S.I., Stepanenko N.P., Zaytsev A.A., Vorobyev V.A. EVALUATING CYTOTOXICITY AND APYROGENICITY OF A BIODEGRADABLE POLYLACTIDE MATRIX. Journal of Siberian Medical Sciences. 2016;(4):10.
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