DISTRIBUTION OF DESMIN IN MYOCARDIUM DURING ACUTE ISCHEMIA IN EXPERIMENT
Abstract
Acute ischemia was induced by ligation of the left coronary artery. Animals were removed from the experiment after 1 hour, 12 and 24 hours. The use of immunohistochemical methods in evaluating the distribution of desmin in cardiomyocytes provides an opportunity to identify pockets of acute ischemic myocardial damage. This article estimates the distribution of desmin around the intercalated discs and Z-bands in the myocardium during an experimental modeling of acute ischemia in laboratory animals, namely Wistar male rats. An immunohistochemical study of the myocardium performed to assess the severity of desmin expression may be informative for morphological diagnostics of sudden cardiac death and used in pathological and forensic-medical practice.
About the Authors
S. V. Savchenko
State Budgetary Educational Institute of Higher Professional Education «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
V. P. Novoselov
State Budgetary Educational Institute of Higher Professional Education «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
R. V. Skrebov
State Budgetary Educational Institute of Higher Professional Education «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
A. S. Morozova
State Budgetary Educational Institute of Higher Professional Education «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
V. A. Grizinger
State Budgetary Educational Institute of Higher Professional Education «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
T. A. Ageeva
State Budgetary Educational Institute of Higher Professional Education «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
S. V. Aidagulova
State Budgetary Educational Institute of Higher Professional Education «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
K. I. Erschov
State Budgetary Educational Institute of Higher Professional Education «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
E. I. Voronina
State Budgetary Educational Institute of Higher Professional Education «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
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Review
For citations:
Savchenko S.V., Novoselov V.P., Skrebov R.V., Morozova A.S., Grizinger V.A., Ageeva T.A., Aidagulova S.V., Erschov K.I., Voronina E.I. DISTRIBUTION OF DESMIN IN MYOCARDIUM DURING ACUTE ISCHEMIA IN EXPERIMENT. Journal of Siberian Medical Sciences. 2016;(4):14.
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