Comparative assessment of acute focal myocardial lesions and desmin expression in cardiomyocytes under acute ischemia within the experiment
Abstract
It was carried out objective of the morphological study performed was to carry out comparative assessment of peculiarities of acute focal cardiomycyte lesions and molecular protein (desmin) expression in myocardium under acute myocardial ischemia within the experiment. Morphological study of myocardium performed under acute ischemia showed correlation between occurrence of acute focal cardiomyocyte lesions and reduction of desmin expression. Comprehensive approach to myocardium state evaluation using polarization microscopy of hematoxylin- and eosin-stained sections, as well as an immunohistochemical assessment of sections, which makes it possible to detect desmin using confocal laser microscopy, should be considered of value in terms of morphological diagnostics of sudden cardiac death, as well as post-mortem and forensic examination.
About the Authors
S. V. Savchenko
Novosibirsk State Medical University
Russian Federation
Russian Federation
V. P. Novoselov
Novosibirsk State Medical University
Russian Federation
Russian Federation
A. S. Grebenshchikova
Novosibirsk State Medical University
Russian Federation
Russian Federation
R. V. Skrebov
Novosibirsk State Medical University
Russian Federation
Russian Federation
G. M. Kazanscaya
E. Meshalkin National Medical Research Centrer (Novosibirsk)
Russian Federation
Russian Federation
V. A. Gritzinger
Novosibirsk State Medical University
Russian Federation
Russian Federation
E. E. Kliver
E. Meshalkin National Medical Research Centrer (Novosibirsk)
Russian Federation
Russian Federation
A. M. Volkov
E. Meshalkin National Medical Research Centrer (Novosibirsk)
Russian Federation
Russian Federation
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Review
For citations:
Savchenko S.V., Novoselov V.P., Grebenshchikova A.S., Skrebov R.V., Kazanscaya G.M., Gritzinger V.A., Kliver E.E., Volkov A.M. Comparative assessment of acute focal myocardial lesions and desmin expression in cardiomyocytes under acute ischemia within the experiment. Journal of Siberian Medical Sciences. 2018;(1):11-20.
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