Assessment of bioelements metabolism and embryonic mortality as a reflection of disturbed ontogeny under destabilizing factors of various nature

Abstract

Specific features of mineral metabolism during pregnancy, whose change under the influence of destabilizing factors can have a negative impact on the homeostasis of the mother - fetus system and lead to disruption of the functioning of the entire system, are defined. An experimental study was conducted over a sample of 70 adult animals, and 420 living fetuses at their 20th day of embryogenesis were obtained and analyzed. In the first series of experiments, females were subjected to a general vertical vibration of 60 minutes per day. In the second series of experimental treatment, cadmium sulfate was administered intraperitoneally to females. The study of mineral metabolism in the mother’s liver during vibration revealed a significant decrease in the amount of Ca by 25 %, Mg by 15 %, Fe by 17 %, but accumulation of Cd by 10 times, Pb by 2 times and Cu by 8 % compared to control, which indicates the pronounced change in the processes of homeostasis in the mother - fetus system and causes an increase in the rates of embryonic mortality. The study of mineral metabolism in both series of experiments testifies to the development of hyperelementosis of a group of toxic trace elements with the simultaneous development, for the most part, of hypoelementosis of vital chemical elements.