Application of dynamic electrical neurostimulation in the pain management in multiple myeloma patients with drug-induced peripheral neuropathy

Abstract

The dynamics of the pain syndrome was studied in 108 patients with multiple myeloma complicated by peripheral neuropathy due to bortezomib injections. All patients were divided into 3 groups: in the 1st group standard polychemotherapy was supplemented with a course of dynamic electrical neurostimulation; in the 2nd one standard treatment was carried out against the background of imitation of a similar procedure from a placebo apparatus; in the 3rd group only standard treatment was administered. By the end of the course of therapy, the severity of the pain syndrome decreased in patients in the 1st group by 1.8 times, in the 2nd and 3rd groups by 1.3 and 1.2 times respectively. The initially increased threshold of pain sensitivity decreased in the 1st group by 24.4 %, whereas in the 2nd and 3rd groupes by 8.3 and 8.1 % respectively. Consequently, the inclusion of dynamic electrical neurostimulation in the treatment of patients with multiple myeloma accompanied by drug-induced peripheral neuropathies reduces the severity of pains and decreases the threshold of pain sensitivity allowing the continuation of specific polychemotherapy.