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Structural functional features of gastric mucosa at patients with hbvand a hcv-infection

https://doi.org/10.31549/2542-1174-2018-4-77-84

Abstract

There are the data in the research devoted to studying of structural features of cell populations of a liver and a gastric mucosa at patients with markers of HCV- and HBV- of an infection. It was performed the clinical morphological research of 95 patients with markers of HCV- and a HBV-infection (52 men and 43 women aged from 16 to 66) and with gastric dysfunction and 41 patient with the chronic gastritis associated with Helicobacter (H.) pylori (group of comparison consisted of 15 patients with the chronic gastritis which isn’t associated with H. pilori ). At all patients with HBV- and a HCV-infection the stomach mucosa is involved in pathological process, at the same time the fibrosing form of a lesion is a gastropathy prevails; it was not found out the essential correlation of structural changes with degree of a hepatitis activity and also with existence of H. pylori . The analysis of structural changes of a stomach at patients with the chronic gastritis associated with H. pylori showed what at a high degree of activity of H. pylori in a gastric mucosa the catarrhal fibrosing process prevails. In the absence of H. pylori fibrosing changes dominate.

About the Authors

D. L. Nepomnyashсhikh
Novosibirsk State Medical University
Russian Federation


O. A. Postnikova
Novosibirsk State Medical University
Russian Federation


E. I. Miguskina
Novosibirsk State Regional Clinical Hospital
Russian Federation


E. E. Abramova
Novosibirsk State Medical University
Russian Federation


O. I. Dorovskaya
Novosibirsk State Regional Clinical Hospital
Russian Federation


References

1. Исаева Г.Ш. Хеликобактериоз у больных хроническим гепатитом С // Фундаментальные исследования. 2012. № 12. С. 266-269.

2. Лапий Г.А., Бакарев М.А., Непомнящих Г.И. и др. Структурные особенности клеточных популяций желудка при хроническом гастрите и хроническом гепатите в условиях персистенции Helicobacter pylori // Бюл. эксперимент. биологии и медицины. 2015. Т. 160, № 10. С. 523-528.

3. Franceschi F., Tortora A., Gasbarrini G., Gasbarrini A. Helicobacter pylori and extragastric diseases // Helicobacter. 2014. Vol. 19, Suppl. 1. P. 52-88.

4. Шептулин А.А. Инфекция Helicobacter pylori: что еще, кроме заболеваний желудка? // Клин. медицина. 2014. T. 92, № 5. С. 33-39.

5. Esmat G., El-Bendary M., Zakarya S., Ela M.A., Zalatak K. Role of Helicobacter pylori in patients with HCV-related chronic hepatitis and cirrhosis with or without hepatocellular carcinoma: possible association with disease progression // J. Viral. Hepat. 2012. Vol. 19 (7). P. 473-479.

6. Abdel Mageed L.M., Hafez М., El-Hameed А.А., Masoud A.G., Elbasmy A.A. Contribution of hepatitis C virus and Helicobacter pylori co-infection as possible predisposing factors in the occurrence of gastric mucosal dysplasia // J. Egypt. Natl. Canc. Inst. 2004. Vol. 16 (4). P. 231-236.

7. Cammarota G., Cianci R., Grillo R.L. et al. Relationship between gastric localization of hepatitis C virus and mucosa-associated lymphoid tissue in Helicobacter pylori infection // Scand. J. Gastroenterol. 2002. Vol. 37 (10). P. 1126-1132.

8. Циммерман Я.С. Нерешенные и спорные проблемы современной гастроэнтерологии. М.: МЕДпресс-информ, 2013. 224 с.

9. Atherton J.C., Blaser M.J. Coadaptation of Helicobacter pylori and humans: ancient history, modern implica-tions // J. Clin. Invest. 2009. Vol. 119 (9). P. 2475-2487.

10. Непомнящих Г.И. Биопсия в гепатологии: Общая патология и патоморфология. М.: Изд-во РАМН, 2014. 192 с.

11. Непомнящих Д.Л., Лапий Г.А., Айдагулова С.В., Бакарев М.А. Биопсия в гастроэнтерологии: Морфогенез общепатологических процессов / под ред. Г.И. Непомнящих. М.: Изд-во РАМН, 2010. 368 с.


Review

For citations:


Nepomnyashсhikh D.L., Postnikova O.A., Miguskina E.I., Abramova E.E., Dorovskaya O.I. Structural functional features of gastric mucosa at patients with hbvand a hcv-infection. Journal of Siberian Medical Sciences. 2018;(4):77-84. (In Russ.) https://doi.org/10.31549/2542-1174-2018-4-77-84

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ISSN 2542-1174 (Print)