Evaluation of the proliferative and antiproliferative properties of endometrial cells during its hyperplasia associated with chronic endometritis
https://doi.org/10.31549/2542-1174-2019-1-28-35
Abstract
Evaluation of proliferative and antiproliferative properties of endometrial cells during its hyperplasia associated with chronic endometritis (CE) was carried out. The study included 60 patients, during histological examination of endometrial bioptates it became known that 20 of them had endometrial hyperplasia without atypia associated with CE (group I), 20 — CE (group II) and 20 — with normal endometrium (group III — control group). It was found that hyperplasia of the endometrium associated with CE was associated with increased expression of Ki-67 (the area of immunopositive structures was 22.73 ± 2.03 % compared to 7.43 ± 1.05 % in the group of chronic endometritis and to 2.0 % in the control group) and p16INK4a (the area of immunopositive structures reached 30.0 % compared to 5.8 % in group II and 2.6 % in group III). The level of expression of p16INK4a is directly proportional to the expression level of Ki-67; Spearman rank correlation coefficient was 0.869, p = 0.0001, Pearson correlation coefficient — 0.909, p = 0.0001.
Co-expression of Ki-67 and p16INK4a may be a signal of cell cycle disorders and requires the search for factors determining the simultaneous expression of these markers in this pathology.
About the Authors
E. A. Kazachkova
South Ural State Medical University
Russian Federation
Russian Federation
Kazachkova Ella Alekseevna — Dr. Sci. (Med.), Professor of the Department of Obstetrics and Gynecology.
64, Vorovskogo Str, Chelyabinsk, 454092.
A. V. Zatvornitskaya
South Ural State Medical University
Russian Federation
Russian Federation
Zatvornitskaya Aleksandra Vadimovna — Post-graduate Student of the Department of Obstetrics and Gynecology.
64, Vorovskogo Str, Chelyabinsk, 454092.
E. E. Voropaeva
South Ural State Medical University
Russian Federation
Russian Federation
Voropaeva Ekaterina Evgenievna — Dr. Sci. (Med.), Associate Professor, Professor of the Department of Pathological Anatomy and Forensic Medicine.
64, Vorovskogo Str, Chelyabinsk, 454092.
E. L. Kazachkov
South Ural State Medical University
Russian Federation
Russian Federation
Kazachkov Evgeny Leonidovich — Dr. Sci. (Med.), Professor, Head of the Department of Pathological Anatomy and Forensic Medicine.
64, Vorovskogo Str, Chelyabinsk, 454092.
Yu. A. Semenov
South Ural State Medical University
Russian Federation
Russian Federation
Semenov Yury Alekseyevich — Cand. Sci. (Med.), Teaching Assistant of the Department of Obstetrics and Gynecology.
64, Vorovskogo Str, Chelyabinsk, 454092.
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Review
For citations:
Kazachkova E.A., Zatvornitskaya A.V., Voropaeva E.E., Kazachkov E.L., Semenov Yu.A. Evaluation of the proliferative and antiproliferative properties of endometrial cells during its hyperplasia associated with chronic endometritis. Journal of Siberian Medical Sciences. 2019;(1):28-35. https://doi.org/10.31549/2542-1174-2019-1-28-35
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