Epidemiological aspects and prevention of tick-borne encephalitis
https://doi.org/10.31549/2542-1174-2019-1-36-48
Abstract
The article analyzes the tendency in the incidence of tick-borne encephalitis (TBE) in Russia during 2001–2016 and the effectiveness of existing methods of specific prevention. During the analyzed period there was an expansion of the TBE area both throughout Russia — up to 48 endemic areas, and in the Siberian Federal District, including in the Novosibirsk Region — up to 23. The incidence in the Russian Federation has a progressive tendency to decrease from 4.4 per 100 thousand citizens in 2001 to 1.4 per 100 thousand citizens in 2016, however, in some regions the all-Russian level was exceeded by 3–10 times in 2016 with the highest rates in the Krasnoyarsk Territory (13.2) and the Republic of Altai (9.4). The Siberian Federal District is a stable leader in terms of morbidity: in 2016 56 % of TBE cases and 62 % of all fatal cases were registered there. From 2002 to 2016, the number of people who are vaccinated in the Russian Federation increased by 1.8 times, there was found a negative correlation between the number vaccinated and the incidence of TBE. The material presented in the article confirms the possibility of effective control of the epidemic process of tick-borne encephalitis using modern methods of immunoprophylaxis.
About the Authors
V. V. ProvorovaRussian Federation
Provorova Veronika Valeryevna — Cand. Sci. (Med.), Associate Professor of the Department of Infectious Diseases, Novosibirsk State Medical University.
52, Krasny Prospect, Novosibirsk, 630091.
E. I. Krasnova
Russian Federation
Krasnova Elena Igorevna — Dr. Sci. (Med.), Professor, Head of the Departament of Infectious Diseases, Novosibirsk State Medical University.
52, Krasny Prospect, Novosibirsk, 630091.
N. I. Hohlova
Russian Federation
Hokhlova Natalia Igorevna — Cand. Sci. (Med.) Associate Professor of the Department of Infectious Diseases, Novosibirsk State Medical University.
52, Krasny Prospect, Novosibirsk, 630091.
T. G. Burmistrova
Russian Federation
Burmistrova Tatyana Germanovna — Doctor of Higher Category, Head of the Department of Neuroinfections, City Infectious Clinical Hospital No. 1.
Novosibirsk.
N. V. Tikunova
Russian Federation
Tikunova Nina Viktorovna — Dr. Sci. (Biol.), Chief Researcher, Head of the Laboratory of Molecular Biology, Institute of Chemical Biology and Fundamental Medicine.
Novosibirsk.
V. G. Kuznetsova
Russian Federation
Kuznetsova Vera Gavriilovna — Dr. Sci. (Med.), Professor of the Departament of Infectious Diseases, Novosibirsk State Medical University.
52, Krasny Prospect, Novosibirsk, 630091.
A. N. Evstropov
Russian Federation
Evstropov Aleksandr Nikolaevich — Dr. Sci. (Med.), Professor, Head of the Departament of Microbiology, Virology, and Immunology, Novosibirsk State Medical University.
52, Krasny Prospect, Novosibirsk, 630091.
References
1. El’kina I.A. (2018). Dependence of tuberculosis epidemic situation on HIV-infection in Kemerovo. Journal of Siberian Medical Sciences, 1, 49–55.
2. Krasnova E.I., Khokhlova N.I., Provorova V.V., Ul’yanova Ya.S., Filina E.I. (2018). Analysis of present-day HIV-infection epidemiological data. Journal of Siberian Medical Sciences, 1, 84–95.
3. Ilinskikh E.N., Lukashova L.V., Lepekhin A.V. et al. (2015). Tick-borne Encephalitis: A Methodical Guide for Doctors, Interns and Clinical Residents. Tomsk, 31 p. In Russ.
4. Guseva E.V., Dudnikova N.S. (2002). Transmissible Neuroinfections: Tick-Borne Encephalitis, Crimean-Congo Hemorrhagic Fever, West Nile Fever: A Literature Review. Vladimir, 94 p. In Russ.
5. Ierusalimskiy A.P. (2001). Tick-borne Encephalitis: A Guide for Doctors. Novosibirsk. In Russ.
6. Skripchenko N.V. (2005). Tick-Borne Encephalitis in Children (Pathogenesis, Clinical Picture, Diagnostics, and Treatment): A Manual for Doctors. Saint-Petersburg, 62 p. In Russ.
7. Okulova N.M. (1994). Causes of Different Severity of Tick-Borne Encephalitis in Humans. Ivanovo, 107 p. In Russ.
8. Morozova O.V., Bakhvalova V.N., Potapova O.F., Grishechkin A.E., Isaeva E.I. (2011). Investigation of the immunogenic and protective effects of inactivated vaccines against tick-borne encephalitis in relation to modern strains of tick-borne encephalitis virus. National Priorities of Russia, 2, 5, 61–63. In Russ.
9. Valarcher J.F., Hägglund S., Juremalm M. et al. (2015). Tick-borne encephalitis. Rev. Sci. Tech., 34, 2, 453–466.
10. Vaccines against tick-borne encephalitis: WHO position paper — recommendations (2011). Vaccine, 29, 48, 8769–8770.
11. Infections transmitted by ticks (2016). On the State of Sanitary and Epidemiological Welfare of the Population in the Russian Federation in 2015: State Report (pp. 121–133). Moscow: Federal Services for Surveillance on Consumer Rights Protection and Human Wellbeing. In Russ.
12. Korenberg E.I. (2008). Modern features of the natural focality of tick-borne encephalitis: new or well-forgotten? Medical Parasitology and Parasitogenic Diseases, 3, 3–8. In Russ.
13. Vorobyeva M.S., Rasshchepkina M.N., Ladyzhenskaya I.P. (2007). Vaccines, immunoglobulins, and test systems for the prevention and diagnosis of tick-borne encephalitis. Problems of Virology, 52, 6, 30–36.
14. Kozlova I.V., Zlobin V.I., Vorobyeva M.S., Verkhozina M.M. (2009). Express Diagnostics and Emergency Prophylaxis of Ixodic Tick Infections. Moscow, 216 p. In Russ.
15. Penevskaya N.A., Rudakov N.V. (2010). The effectiveness of immunoglobulin preparations for post-exposure prophylaxis of tick-borne encephalitis in Russia (Review of half a century of experience). Medical Parasitology and Parasitogenic Diseases, 1, 53−59.
16. Olefir U.V., Merkulov V.A., Vorobieva M.S. et al. (2016). Evaluation of extra prophilaxy and treatment of tick-borne encephalitis with human specific immunoglobulin. Int. J. of Applied and Fundamental Researches, 8, 162–170.
17. Leonova G.N. (2017). Influence of specific antibodies on the tick-borne encephalitis virus elimination process. Health. Medical Ecology. Science, 68, 1, 43–47.
18. Romanenko V.V., Yesunina M.S., Kilyachina S.S. (2007). Experience in implementing the mass immunization program against tick-borne encephalitis in the Sverdlovsk Region. Problems of Virology, 52, 6, 23–25.
19. Lvov D.K., Zlobin V.I. (2007). Prevention of tick-borne encephalitis at the present stage: Strategy and tactics. Problems of Virology, 52, 5, 26–30.
20. Opeykina N.N., Skudarnov S.E., Kurtasova L.M., Shul’min A.V., Vasil’eva A.A. (2015). The analysis of the morbidity of tick-borne viral encephalitis in the Krasnoyarsk Region. Siberian Medical Review, 2, 92, 81–85.
21. Kleiter I., Jilg W., Bogdahn U., Steinbrecher A. (2007). Delayed humoral immunity in a patient with severe tick-borne encephalitis after complete active vaccination. Infection, 35, 1, 26–29.
22. Vozgoment O.V., Krivenko E.I. (2002). Version of mechanism of development of severe complication of vaccination against tick-borne encephalitis. Immunology, 1, 40–43. In Russ.
23. Schattenfroh С. (2004). Acute disseminated encephalomyelitis after active immunization against early summer encephalitis. Nervenarzt., 75, 8, 776–779.
24. Sander D., Scholz C., Eiben P., Klingelhöfer J. (1995). Plexus neuropathy following vaccination against tick-borne encephalitis and tetanus due to a sports related altered immune state. Neurol. Res., 17, 4, 316–319.
25. Sander D., Scholz C.W., Eiben P., Klingelhöfer J. (1994). Postvaccinal plexus neuropathy following vaccination against tick-borne encephalitis and tetanus in a competitive athlete. Clin. Investig., 72, 5, 399.
26. Hainz U., Jenewein B., Asch E. et al. (2005). Insufficient protection for healthy elderly adults by tetanus and TBE vaccines. Vaccine, 23, 25, 3232–3235.
27. Pogodina V.V., Levina L.S., Skrynnik S.M. et al. (2013). Tick-borne encephalitis with fulminant course and lethal outcome in patients after plural vaccination. Problems of Virology, 58, 2, 33–37.
28. Pogodina V.V., Luchinina S.V., Stepanova O.N. et al. (2015). Unusual case of letal of tick-borne encephalitis in patient vaccinated with vaccines produced from different viruses strains (the Chelyabinsk Region). Epidemiology and Infectious Diseases, 20, 1, 56–64.
29. Votyakov V.I., Zlobin V.I., Mishaeva N.P. (2002). Tick-borne encephalitis of Eurasia. Issues of Ecology, Molecular Epidemiology, Nosology, Evolution. Novosibirsk: Nauka, 438 p. In Russ.
30. Zlobin V.I., Verkhozina M.M., Demina T.V. et al. (2007). Molecular epidemiology of tick-borne encephalitis. Problems of Virology, 52, 6, 4–13.
31. Leonova G.N., Pavlenko E.V., Krylova Yu.V. (2006). Vaccine Prophylaxis of Tick-borne Encephalitis. Vladivostok: Primorskiy Poligrafkombinat, 100 p. In Russ.
32. Terekhina L.L., Rogova Yu.V., Romanova L.Yu. et al. (2012). Protective properties of vaccine preparations against tick-borne encephalitis for protection against different subtypes of tick-borne encephalitis virus. Proceeding IV Annual All-Russia congress on infectious diseases (pp. 373–374). Moscow. In Russ.
33. Levina L.S., Pogodina V.V. (1988). Persistence of tick-borne encephalitis virus in the vaccinated organism. Problems of Virology, 33, 4, 485–490. In Russ.
34. Pogodina V.V., Bochkova N.G., Levina L.S. (1984). Persistence of tick-borne encephalitis virus in monkeys. VII. Some features of immune response. Acta Virol., 28, 5, 407–415.
35. Korenberg E.I. (2013). Infections transmitted by ticks forest area and the strategy of prevention: changing of priorities. Epidemiology and Vaccine Prevention, 5, 72, 7–17.
Review
For citations:
Provorova V.V., Krasnova E.I., Hohlova N.I., Burmistrova T.G., Tikunova N.V., Kuznetsova V.G., Evstropov A.N. Epidemiological aspects and prevention of tick-borne encephalitis. Journal of Siberian Medical Sciences. 2019;(1):36-48. https://doi.org/10.31549/2542-1174-2019-1-36-48