Research of mechanisms of myocardial remodelling of the left ventricle in patients with metabolic sleep obstructive apnea syndrome
https://doi.org/10.31549/2542-1174-2019-1-119-128
Abstract
The dynamics of the main echocardiographic parameters of left ventricular myocardium (LVM), reflecting the mechanisms of myocardial remodeling of left ventricle in patients with metabolic syndrome and sleep obstructive apnea syndrome (SOAS) was studied.
The research involved 98 men who are overweight (BMI > 30 kg/m2) with established earlier a diagnosis of hypertension and blood pressure stabilization achieved against a background of adequate medical therapy. Study participants underwent cardiorespiratory monitoring night’s sleep for diagnosis of sleep obstructive apnea syndrome with assessment of apnea/hypopnea index and average nocturnal saturation, and EchoCG was performed to assess the structural parametersof LVM, such as left ventricle (LV) diameters, the thickness of the interventricular septum and posterior wall of LV with further calculation of LVM mass index.
The data revealed reliable correlation of left atrium length and thickness of the left atrial posterior wall with an index of apnea/hypopnea (р < 0.05). No significant association study of structural parameters of LVM with the level of nocturnal hypoxemia have been identified. The study conclusions were drawn about the likely impact of the periodic independent upper airway obstruction in the remodeling of the left ventricle in the absence of a direct influence on the process of remodeling nocturnal hypoxemia.
About the Authors
A. V. Yakovlev
Railway clinical hospital on the station Novosibirsk-Glavniy; Novosibirsk State Medical University
Russian Federation
Russian Federation
Yakovlev Aleksey Vladimirovich — Cand. Sci. (Med.), Assistant Professor of the Department of Therapy, Hematology and Transfusiology, Novosibirsk State Medical University; Chief of the Cardiological Department, “RR” OJSK, Railway clinical hospital on the station Novosibirsk-Glavniy.
2a, Vladimirovskiy Spusk, 630003, Novosibirsk.
S. V. Ponomarev
Railway clinical hospital on the station Novosibirsk-Glavniy
Russian Federation
Russian Federation
Ponomarev Sergey Vladimirovich — Therapist of Reception Ward, “RR” OJSK, Railway clinical hospital on the station Novosibirsk-Glavniy.
Novosibirsk.
A. N. Ryabikov
Novosibirsk State Medical University; Research Institute of Internal and Preventive Medicine
Russian Federation
Russian Federation
Ryabikov Andrey Nikolaevich — Dr. Sci. (Med.), Professor of the Department of Therapy, Hematology and Transfusiology, Novosibirsk State Medical University; Leading Researcher of Laboratory of Etiopathogenesis and Clinic of Internal Diseases, Research Institute of Internal and Preventive Medicine.
Novosibirsk.
N. F. Yakovleva
Novosibirsk State Medical University
Russian Federation
Russian Federation
Yakovleva Natalya Faritovna — Cand. Sci. (Med.), Teaching Assistant of the Department of Polyclinic Therapy and General Medical Practice (Family Medicine), Novosibirsk State Medical University.
Novosibirsk.
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Review
For citations:
Yakovlev A.V., Ponomarev S.V., Ryabikov A.N., Yakovleva N.F. Research of mechanisms of myocardial remodelling of the left ventricle in patients with metabolic sleep obstructive apnea syndrome. Journal of Siberian Medical Sciences. 2019;(1):119-128. https://doi.org/10.31549/2542-1174-2019-1-119-128
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