Effect of Streptococcus viridans on the development of coinfections in HIV-infected patients
Abstract
We analysed 193 results of a microbiological study of sputum with culture typing in HIV-infected patients. The data obtained are compared with the existing clinic picture of infectious lesions of the respiratory system. Four groups were formed: 1st group — patients with bacterial microflora + Streptococcus (S.) viridans + pneumonia clinical picture (n = 25), 2nd — S. viridans + clinical picture of pneumonia (n = 114), 3rd — Mycobacterium tuberculosis + S. viridans + clinical picture of pneumonia (n = 19), 4th — S. viridans without clinic picture of pneumonia (n = 35).
In the studied groups, statistically significant differences in immunological status (number of CD4+ lymphocytes), localization of inflammatory changes in the lung tissue, the degree of contamination of S. viridans and fungi of the genus Candida in sputum were observed. In HIV-infected patients with S. viridans verification and a clinical picture of pneumonia, radiographic changes in the lower left lobe and unilateral hydrothorax were more common. The massive growth of S. viridans was observed in patients with bacterial pneumonia, pulmonary tuberculosis, as well as in the group with an unspecified etiological agent of lung tissue damage.
The data obtained during the study can be used in practice in the differential diagnosis of lower respiratory tract infections in HIV-infected patients.
About the Authors
L. V. Puzyreva
Omsk State Medical University
Russian Federation
Russian Federation
Puzyreva Larisa Vladimirovna — Cand. Sci. (Med.), Associate Professor of the Department of Phthisiology, Phthisiosurgery and Infectious Diseases.
12, Lenina Str., Omsk, 644099
A. V. Mordyk
Omsk State Medical University
Russian Federation
Russian Federation
Mordyk Anna Vladimirovna — Dr. Sci. (Med.), Professor, Head of the Department of Phthisiology, Phthisiosurgery and Infectious Diseases
I. Ya. Izvekova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Izvekova Irina Yakovlevna — Dr. Sci. (Med.), Associate Professor, Professor of the Infections Diseases Department
E. I. Krasnova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Krasnova Elena Igorevna — Dr. Sci. (Med.), Professor, Head of the Infectious Diseases Department
L. A. Rodkina
Infectious Clinical Hospital No. 1 named after D.M. Dalmatov
Russian Federation
Russian Federation
Rodkina Larisa Anatolyevna — Cand. Sci. (Med.), Head of Clinical and Laboratory Department.
Omsk
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Review
For citations:
Puzyreva L.V., Mordyk A.V., Izvekova I.Ya., Krasnova E.I., Rodkina L.A. Effect of Streptococcus viridans on the development of coinfections in HIV-infected patients. Journal of Siberian Medical Sciences. 2019;(3):4-14.
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