Follicular-cell tumors of the thyroid gland: clinical and morphological characteristics in children and adolescents
Abstract
Operational bioptic material of thyroid gland tumors taken from 55 children and adolescents 8-17 years old was investigated. Taking into account the new classification of tumors (WHO, 2017), tumors of the follicular structure were verified in 21 patients: follicular cancer (FC, n = 7), follicular variant of papillary cancer (FV PC, n = 7), follicular adenoma (FA, n = 4), noninvasive follicular thyroid neoplasm with nuclei of papillary type (NFT, n = 2), follicular thyroid tumor of uncertain malignant potential (n = l). The conducted study indicates a low incidence of noninvasive follicular thyroid neoplasm with nuclei of papillary type in children and adolescents — 4% of cases. The peculiarities of benign and malignant tumors with nuclei of papillary type are the following: smoothing of sexual differences, frequently combined with autoimmune diseases of the thyroid gland, the increase of karyometric parameters as compared with follicular adenomas and carcinomas. Ultrastructural analysis showed that the tumor cells with nuclei of papillary type (FV PC, NFT) distinguish themselves by expressed polymorphism. At the same time, cells with signs of neuroendocrine differentiation prevail in a NFT neoplasm with nuclei of papillary type in contrast to FV PC, in which cellular forms with the loss of secretory activity and organospecificity predominate.
About the Authors
I. A. Pasternak
South Ural State Medical University
Russian Federation
Russian Federation
Pasternak Ilona Anatolyevna — Cand. Sci. (Med.), Assistant of the Pathologic Anatomy and Forensic Medicine Department.
64, Voro-vskogo Str., Chelyabinsk, 454092
E. L. Kazachkov
South Ural State Medical University
Russian Federation
Russian Federation
Kazachkov Evgeniy Leonidovich — Dr. Sci. (Med.), Professor, Head of the Pathologic Anatomy and Forensic Medicine Department.
Chelyabinsk
A. E. Pasternak
Chelyabinsk Regional Bureau of Forensic Medical Examination
Russian Federation
Russian Federation
Pasternak Aleksey Evgenyevich — Cand. Sci. (Med.), Chief
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Review
For citations:
Pasternak I.A., Kazachkov E.L., Pasternak A.E. Follicular-cell tumors of the thyroid gland: clinical and morphological characteristics in children and adolescents. Journal of Siberian Medical Sciences. 2019;(3):15-23.
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