Plant phenolic compounds in prevention of metabolic disturbances during nitrogen oxides intoxication in experiment
https://doi.org/10.31549/2542-1174-2020-1-44-54
Abstract
An experiment, aimed at studying the influence of prophilactic administration of viburnum and eleutherococcus extracts on biochemical parameters of blood during nitrogen oxides intoxication, was performed on 80 Wistar rats. The animals were divided into 4 groups: 1st — intact, 2nd — nitrogen oxides intoxication, 3rd — viburnum extract + nitrogen oxides, 4th — eleutherococcus extract + nitrogen oxides. Nitrogen oxides intoxication was executed for 6 min at a concentration of 4.3 mg/m3 (the maximum permissible concentration in atmospheric air — 0.4 mg/m3). Intoxication was accompanied by depletion of the body’s antioxidant defense system, development of severe dyslipoproteinemia and dyslipidemia. The survival rate of animals during intoxication preceded by administration of viburnum and eleutherococcus extracts was 70%, while during intoxication without prophylactic administration of drugs — 40%.
Thus, the prophylactic intake of viburnum and eleutherococcus extracts can be recommended to residents of ecologically unfavorable regions to reduce the effects of anthropogenic impact.
About the Authors
E. S. Drugova
V.I. Il’ichev Pacific Oceanological Institute
Russian Federation
Russian Federation
Drugova Elena Sergeyevna — Cand. Sci. (Biol.), Researcher, Biochemistry Laboratory
43, Baltiyskaya Str., Vladivostok, 690041
N. F. Kushnerova
V.I. Il’ichev Pacific Oceanological Institute
Russian Federation
Russian Federation
Kushnerova Natalya Fedorovna — Dr. Sci. (Biol.), Professor, Head, Biochemistry Laboratory
Vladivostok
V. Yu. Merzlyakov
V.I. Il’ichev Pacific Oceanological Institute
Russian Federation
Russian Federation
Merzlyakov Valery Yuryevich — Researcher, Biochemistry Laboratory
Vladivostok
S. E. Fomenko
V.I. Il’ichev Pacific Oceanological Institute
Russian Federation
Russian Federation
Fomenko Svetlana Evgenyevna — Cand. Sci. (Biol.), Leading Researcher, Biochemistry Laboratory
Vladivostok
V. G. Sprygin
V.I. Il’ichev Pacific Oceanological Institute
Russian Federation
Russian Federation
Sprygin Vladimir Gennadyevich — Cand. Sci. (Biol.), Leading Researcher Biochemistry Laboratory
Vladivostok
T. V. Momot
Far Eastern Federal University
Russian Federation
Russian Federation
Momot Tatyana Viktorovna — Cand. Sci. (Med.), Head Medical Biochemistry and Biophysics Department, School of Biomedicine
Vladivostok
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Review
For citations:
Drugova E.S., Kushnerova N.F., Merzlyakov V.Yu., Fomenko S.E., Sprygin V.G., Momot T.V. Plant phenolic compounds in prevention of metabolic disturbances during nitrogen oxides intoxication in experiment. Journal of Siberian Medical Sciences. 2020;(1):44-54. https://doi.org/10.31549/2542-1174-2020-1-44-54
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