Evaluation of the efficacy of new vaginal suppositories with garden sage leaves solid extract in treatment of non-specific vaginitis in experiment

Abstract

The pharmacological activity of vaginal suppositories with the garden sage leaves solid extract (GSLSE) was studied on a model of the induced vaginitis during experiment which was conducted on 36 female rats. Animals were divided into 6 groups (6 rats in each one): the 1^st group was control one (intact rats); the 2^nd group was with the induced vaginitis; the 3^rd group was with the induced vaginitis and pharmacological correction by vaginal suppositories Metronidazole in a dose of 43 mg/kg; the 4^th group was with induced vaginitis and sea-buckthorn oil suppositories in a dose of 43 mg/kg; the 5^th group was the induced vaginitis and vaginal suppositories with GSLSE in a dose of 4.3 mg/kg; the 6^th group was the induced vaginitis and vaginal suppositories with GSLSE in a dose of 8.5 mg/kg. An experimental vaginitis was modeled by single intravaginal injection of phlogogen at a dose of 0.2 ml per one animal.
It is established that the studied drug in a dose of 4.3 mg/kg shows the maximum regenerative activity. So, when correcting vaginitis with the studied drug in a dose of 4.3 mg/kg thickness of epithelium was 65.06 [38.2–89.4] μm (when treated with Metronidazole suppositories and suppositories with sea-buckthorn oil 43.3 [34.7–55.6] and 76.6 [48.7–107.1] μm respectively), and the ratio of epithelium and stroma of lamina propria of vaginal mucosa was close to normal.
Thus, vaginal suppositories with GSLSE are perspective for further studying as a potential tool for the treatment of infectious and inflammatory diseases of lower female genital tract.