The study of the release of active substances from hemostatic agent on hydrophilic basis
https://doi.org/10.31549/2542-1174-2020-1-100-107
Abstract
The kinetics of the release of active substances (aminocaproic acid and iron (III) chloride) from a semisolid dosage form with and without inclusion of iron nanoparticles has been studied. Aminocaproic acid was determined by direct spectrophotometry at a wavelength of 568 nm, iron (III) chloride was determined photometrically from the complexation reaction with sulfosalicylic acid at a wavelength of 510 nm. Validation of the developed methods was carried out by such parameters, as specificity, detection limit, limit of quantification, linearity, correctness, precision of the analytical method. The best results on the release of active substances have been obtained in samples of ointments with iron nanoparticles which was statistically significantly different from the parameters of release from control samples (p < 0.05).
About the Authors
Yu. N. Barsukova
Ural State Medical University
Russian Federation
Russian Federation
Barsukova Yuliya Nikolayevna — Post-Graduate student, Department of Pharmacy and Chemistry
3, Repina Str., Yekaterinburg, 620028
O. A. Melnikova
Ural State Medical University
Russian Federation
Russian Federation
Melnikova Olga Aleksandrovna – Dr. Sci. (Pharmaceut.), Assistant Professor, Department of Pharmacy and Chemistry
Yekaterinburg
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Review
For citations:
Barsukova Yu.N., Melnikova O.A. The study of the release of active substances from hemostatic agent on hydrophilic basis. Journal of Siberian Medical Sciences. 2020;(1):100-107. https://doi.org/10.31549/2542-1174-2020-1-100-107
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