Further development of intensive care in patients with acute psychodysleptic poisoning
https://doi.org/10.31549/2542-1174-2020-3-39-51
Abstract
Acute psychodysleptic poisoning is accompanied with the activation of anaerobic processes, development of hypoxia, rhabdomyolysis and an inflammatory reaction, which ultimately determines the occurrence of complications (cerebral ischemia, hypotension, hepatorenal syndrome, pneumonia, etc.). In order to improve the intensive care of patients with acute psychodysleptic poisoning, a study was carried out in which 148 patients with acute psychodysleptic poisoning participated. The control group consisted of 75 patients who received conventional therapy in accordance with Federal Clinical Guidelines. The study group included 73 patients who were additionally prescribed ethylmethylhydroxypyridine succinate (mexidol).
Acute psychodysleptic poisoning, even mild, is accompanied by the development of metabolic disorders that cannot be corrected by standard therapy, despite the consciousness recovery and relief of tachycardia. Acute psychodysleptic poisoning of moderate severity is characterized by the development of anaerobic processes, hepatorenal syndrome and inflammatory response. Conventional therapy could not stop the pathological reactions in a short time. Additional use of mexidol contributed to a decrease in the intensity of anaerobic processes and the elimination of metabolic disorders, which made it possible to shorten the rehabilitation period by 3–4 times.
About the Authors
А. N. Lodyagin
Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Russian Federation
Lodyagin Aleksey Nikolayevich — Dr. Sci. (Med.), Head, Clinical Toxicology Department
Russian Federation
Lodyagin Aleksey Nikolayevich — Dr. Sci. (Med.), Head, Clinical Toxicology Department
Е. А. Rakhmanova
Krasnoyarsk State Medical University; N.S. Karpovich Krasnoyarsk Interdistrict Clinical Emergency Hospital
Russian Federation
Rakhmanova Ekaterina Andreyevna — Assistant, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with the Postgraduate Course (PC); Anesthesiologist-Resuscitator, Acute Poisoning Department
Russian Federation
Rakhmanova Ekaterina Andreyevna — Assistant, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with the Postgraduate Course (PC); Anesthesiologist-Resuscitator, Acute Poisoning Department
Е. А. Popova
Krasnoyarsk State Medical University; N.S. Karpovich Krasnoyarsk Interdistrict Clinical Emergency Hospital
Russian Federation
Popova Elena Anatolyevna — Dr. Sci. (Med.), Professor, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with PC; Anesthesiologist-Resuscitator, Acute Poisoning Department
Russian Federation
Popova Elena Anatolyevna — Dr. Sci. (Med.), Professor, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with PC; Anesthesiologist-Resuscitator, Acute Poisoning Department
B. V. Batotzyrenov
Saint-Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Russian Federation
Russian Federation
Batotzyrenov Bair Vasilyevich — Dr. Sci. (Med.), Chief Researcher, Department of Clinical Toxicology
3A, Budapeshtskaya str., Saint-Petersburg, 192242
А. А. Popov
Krasnoyarsk State Medical University; N.S. Karpovich Krasnoyarsk Interdistrict Clinical Emergency Hospital
Russian Federation
Popov Andrey Alekseevich — Dr. Sci. (Med.), Professor, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with PC; Curator, Intensive Care Unit No. 5
Russian Federation
Popov Andrey Alekseevich — Dr. Sci. (Med.), Professor, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with PC; Curator, Intensive Care Unit No. 5
M. А. Bolshakova
Krasnoyarsk State Medical University; N.S. Karpovich Krasnoyarsk Interdistrict Clinical Emergency Hospital
Russian Federation
Bolshakova Mariya Andreyevna — Cand. Sci. (Med.), Associate Professor, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with PC; Anesthesiologist-Resuscitator, Intensive Care Unit No. 5
Russian Federation
Bolshakova Mariya Andreyevna — Cand. Sci. (Med.), Associate Professor, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with PC; Anesthesiologist-Resuscitator, Intensive Care Unit No. 5
R. M. Rakhmanov
Krasnoyarsk State Medical University; N.S. Karpovich Krasnoyarsk Interdistrict Clinical Emergency Hospital
Russian Federation
Rakhmanov Roman Mikhailovich — Assistant, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with PC; AnesthesiologistResuscitator, Intensive Care Unit No. 5
Russian Federation
Rakhmanov Roman Mikhailovich — Assistant, Department of Mobilization Training of Health Care, Disaster Medicine and Ambulance with PC; AnesthesiologistResuscitator, Intensive Care Unit No. 5
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Review
For citations:
Lodyagin А.N., Rakhmanova Е.А., Popova Е.А., Batotzyrenov B.V., Popov А.А., Bolshakova M.А., Rakhmanov R.M. Further development of intensive care in patients with acute psychodysleptic poisoning. Journal of Siberian Medical Sciences. 2020;(3):39-51. https://doi.org/10.31549/2542-1174-2020-3-39-51
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