Etiological and pathomorphological characteristics of congenital pneumonia
https://doi.org/10.31549/2542-1174-2020-3-52-63
Abstract
In order to study the etiological factors and pathomorphological changes in lungs in congenital pneumonia, 80 case histories and autopsy records of deceased children who were admitted to the pathological departments of multidisciplinary children’s hospitals in Novosibirsk in 2018–2019 were analyzed. Such parameters as gender, age, maturity, data from intravital and postmortem bacteriological tests, as well as the results of histological examination of internal organs and, taking into account the continuity of the mother — placenta — fetus system and the role of the liver as a barrier organ in perinatal infections, placenta and liver, were assessed.
It was found that fatal outcomes due to congenital pneumonia are more often observed in boys, and mainly in premature newborn infants. Congenital pneumonia in most cases was part of a generalized infectious process (neonatal sepsis, intrauterine infection) (up to 85%), with frequent damage to the intestine (enterocolitis), liver (fetal hepatitis). The main etiological factors of congenital pneumonia are Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli or bacterial-bacterial associations of the above pathogens. The morphological picture of the lungs was dominated by desquamative interstitial pneumonia.
About the Authors
А. P. Nadeev
Novosibirsk State Medical University; Federal Research Center for Fundamental and Translational Medicine
Russian Federation
Russian Federation
Nadeev Aleksandr Petrovich — Dr. Sci. (Med.), Professor, Head, Department of Pathological Anatomy
52, Krasny Prospect, Novosibirsk, 630091
M. А. Karpov
Novosibirsk State Medical University; Federal Research Center for Fundamental and Translational Medicine
Russian Federation
Russian Federation
Karpov Mikhail Aleksandrovich — Cand. Sci. (Med.), Associate Professor, Department of Pathological Anatomy
Novosibirsk
А. А. Abyshev
Novosibirsk State Medical University
Russian Federation
Russian Federation
Abyshev Aleksandr Andreevich — Post-graduate Student, Department of Pathological Anatomy
Novosibirsk
V. D. Klochin
Federal Research Center for Fundamental and Translational Medicine
Russian Federation
Russian Federation
Klochin Vitaliy Dmitrievich — Post-graduate Student
Novosibirsk
Е. V. Ovsyanko
Novosibirsk State Medical University
Russian Federation
Russian Federation
Ovsyanko Elena Vladimirovna — Dr. Sci. (Med.), Professor, Department of Human Anatomy named after Acad. Yu.I. Borodin
Novosibirsk
А. B. Loginova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Loginova Anastasia Borisovna — 4th-year Student, Medical Faculty
Novosibirsk
S. L. Lyashenko
Novosibirsk State Medical University
Russian Federation
Russian Federation
Lyashenko Svetlana Leonidovna — Resident, Department of Pathological Anatomy
Novosibirsk
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Review
For citations:
Nadeev А.P., Karpov M.А., Abyshev А.А., Klochin V.D., Ovsyanko Е.V., Loginova А.B., Lyashenko S.L. Etiological and pathomorphological characteristics of congenital pneumonia. Journal of Siberian Medical Sciences. 2020;(3):52-63. https://doi.org/10.31549/2542-1174-2020-3-52-63
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