Campylobacter-associated hemolytic uremic syndrome in children: two case histories
https://doi.org/10.31549/2542-1174-2020-3-93-107
Abstract
Hemolytic uremic syndrome (HUS) is a special form of thrombotic microangiopathy (TMA) characterized by obligate kidney damage. The development of HUS is most often associated with enterohemorrhagic escherichiosis and shigellosis, however, at the present stage there are reports of new bacterial pathogens that may be responsible for the development of this form of TMA. One of them is Campylobacter. The HUS pathogenesis in infections caused by Campylobacter is unknown, which does not allow us to develop adequate approaches to the diagnosis, treatment and rehabilitation of these conditions. In 2018 there were recorded two cases of HUS in children in Novosibirsk, Campylobacter was identified as the etiological agent. These cases are described in the article. The presented description demonstrates the complexity of patient management and the high urgency of Campylobacter-associated HUS. The analysis makes the Shiga-toxin mediated mechanism of TMA development in campylobacter infections doubtful, however, it does not allow to exclude both the neuraminidase and autoimmune genesis of such changes.
Thus, Campylobacter-associated HUS requires further study in order to develop and optimize approaches to the diagnosis and treatment of this condition.
About the Authors
G. S. Karpovich
Novosibirsk State Medical University
Russian Federation
Russian Federation
Karpovich Gleb Sergeyevich — Assistant, Infectious Disease Department
52, Krasny Prospect, Novosibirsk, 630091
A. V. Vasyunin
Novosibirsk State Medical University
Russian Federation
Russian Federation
Vasyunin Aleksandr Vasilyevich — Dr. Sci. (Med.), Professor, Infectious Disease Department
Novosibirsk
E. I. Krasnova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Krasnova Elena Igorevna — Dr. Sci. (Med.), Head, Infectious Disease Department
Novosibirsk
M. A. Karpov
Novosibirsk State Medical University
Russian Federation
Russian Federation
Karpov Mihail Aleksandrovich — Cand. Sci (Med.), Assistant Professor, Pathological Anatomy Department
Novosibirsk
I. Ya. Izvekova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Izvekova Irina Yakovlevna — Dr. Sci. (Med.), Professor, Infectious Disease Department
Novosibirsk
T. G. Surdina
Children’s City Hospital No. 3
Russian Federation
Russian Federation
Surdina Tatyana Gennadyevna — Deputy Chief Doctor
Novosibirsk
L. I. Enivatova
Children’s City Hospital No. 3
Russian Federation
Russian Federation
Enivatova Liliya Ivanovna — Emergency Physician, Head, Resustitation and Intensive Care Department
Novosibirsk
V. G. Kuznetsova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Kuznetsova Vera Gavriilovna — Dr. Sci. (Med.), Professor, Infectious Disease Department
Novosibirsk
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Review
For citations:
Karpovich G.S., Vasyunin A.V., Krasnova E.I., Karpov M.A., Izvekova I.Ya., Surdina T.G., Enivatova L.I., Kuznetsova V.G. Campylobacter-associated hemolytic uremic syndrome in children: two case histories. Journal of Siberian Medical Sciences. 2020;(3):93-107. https://doi.org/10.31549/2542-1174-2020-3-93-107
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