Heparin sensitization of fentanyl initiated mu-receptors
https://doi.org/10.31549/2542-1174-2021-1-20-32
Abstract
Heparin is an anticoagulant widely used in clinical practice. In addition to anticoagulant activity, heparin has a cytostatic, bacteriostatic, antilipemic, radioprotective effect, and exhibits antiallergic and hypotensive action. Heparin modulates cardiotropic, neurotropic, antihypoxic, anti-ischemic properties of regulatory peptides and pharmacological agents used in pain relief and anesthesia. At the same time, there is very little information about the antinociceptive effect of heparin.
The aim of this work is to study the effect of heparin in combination with the opioid agonist fentanyl on mu-opioid receptors at the spinal and supraspinal levels. In experiments on laboratory rats, it was established that heparin, when preadministered and combined with fentanyl, increases the latency in the tail flick test and the paw licking test. Naloxone, an opioid receptor antagonist, reduces antinociceptive efficacy of the studied compounds. Protamine sulfate also reduces the level of heparin sensitization of opioid receptors.
Thus, the obtained data allow us to speak about the sensitizing effect of heparin on initiated by an agonist mu-opioid receptors at the spinal and supraspinal levels.
About the Authors
A. Е. Khomutov
Lobachevsky State University of Nizhny Novgorod
Russian Federation
Russian Federation
Khomutov Aleksandr Evgenievich — Dr. Sci. (Biol.), Professor, Department of Physiology and Anatomy, Institute of Biology and Medicine
A. V. Deryugina
Lobachevsky State University of Nizhny Novgorod
Russian Federation
Russian Federation
Deryugina Anna Vyacheslavovna — Dr. Sci. (Biol.), Associate Professor, Head, Department of Physiology and Anatomy, Institute of Biology and Medicine
A. S. Lizunova
Ryazan State Medical University n.a. academician I.P. Pavlov
Russian Federation
Russian Federation
Lizunova Alla Sergeevna — Cand. Sci. (Biol.), Associate Professor, Department of Pharmacognosy.
9, Vysokovoltnaya str., Ryazan, 390026
Z. V. Bobrova
Institute of Physiologically Active Substances (Chernogolovka)
Russian Federation
Russian Federation
Bobrova Zoya Vladimirovna — Junior Researcher, Laboratory of Immunochemistry.
Chernogolovka
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Review
For citations:
Khomutov A.Е., Deryugina A.V., Lizunova A.S., Bobrova Z.V. Heparin sensitization of fentanyl initiated mu-receptors. Journal of Siberian Medical Sciences. 2021;(1):20-32. https://doi.org/10.31549/2542-1174-2021-1-20-32
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