The influence of the stripping voltammetry parameters on the quantitative determination of the bismuth ion in the pharmaceutical substance of bismuth subsalicylate
Abstract
The results of the study of the conditions for the analysis of active pharmaceutical substance (APS) of bismuth subsalicylate by the method of stripping voltammetry are presented. This method is not pharmacopoeial, but it is widely used for the analysis of bismuth compounds in other objects. The influence of the main parameters of the method, in particular, the beginning and rate of a sweep, the time and potential of accumulation, on the quantitative determination of the bismuth ion in the studied APS was investigated. The dependence of the quantitative indicators of the voltammetric peak on the beginning of the sweep was not revealed. When the sweep rate changes from 60 to 120 s, the peak height changes in proportion to the rate value. The optimal range of the analyte accumulation rate on the electrode was determined, which allows changing this parameter during the test. The accumulation potential is of the greatest interest for research since this parameter has the greatest influence on the quantitative characteristics of the peak.
Thus, the method of stripping voltammetry can be used to analyze the active pharmaceutical substance of bismuth subsalicylate.
About the Authors
A. A. Vizer
Novosibirsk State Medical University
Russian Federation
Russian Federation
Vizer Anna Aleksandrona — Post-graduate Student, Department of Pharmaceutical Chemistry.
52, Krasny Prospect, Novosibirsk
E. A. Ivanovskaya
Novosibirsk State Medical University
Russian Federation
Russian Federation
Ivanovskaya Elena Alekseevna — Dr. Sci. (Pharm.), Professor, Head, Department of Pharmaceutical Chemistry.
Novosibirsk
References
1. Bierer D.W. (1990). Bismuth subsalicylate: history, chemistry, and safety. Rev. Infect. Dis., 12 (1), S3-S8. doi: 10.1093/clinids/12.supplement_1.s3.
2. McQuaid K.R. (2014). Drugs Used in the Treatment of Gastrointestinal Diseases (Chapter 62). In: Katzung B.G., Trevor A.J.(eds.) Basic and Clinical Pharmacology. 13th ed. San Francisco, McGraw-Hill Medical.
3. Bismuth subsalicylate 1495 (01/2008) (2016). In European Pharmacopoeia 9.0. Strasbourg: Directorate for the Quality of Medicines and HealthCare, Council of Europe. 2, p. 1854.
4. The United States Pharmacopeia 41. National Formulary 36 (2018). In The United States Pharmacopeial Con vention. Rockville (MD). 1, pp. 536-539.
5. Hentze G. (2008). Polarography and Voltammetry. Theoretical Foundations and Analytical Practice (A.V. Garmash, A.I. Kamenev, Trans.). Мoscow, 284 p. In Russ.
6. A guide for mastering the method of stripping voltammetry and working on a voltammetric analyzer. TA-Lab. Retrieved September 15, 2020 from https://docplayer.ru/80492246-Posobie-po-os-voeniyu-metoda-inversionnoy-voltamperometrii-i-raboty-na-voltamperometricheskom-analizatore-ta-lab.html. In Russ.
Review
For citations:
Vizer A.A., Ivanovskaya E.A. The influence of the stripping voltammetry parameters on the quantitative determination of the bismuth ion in the pharmaceutical substance of bismuth subsalicylate. Journal of Siberian Medical Sciences. 2020;(4):30-37.
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