The nature and dynamics of the facet joints changes in varying grades of intervertebral disc degeneration
Abstract
Biopsy materials from 145 patients were studied. All patients after a comprehensive clinical and instrumental examination, taking into account the grade of intervertebral disk degeneration according to Pfirrmann, underwent decompression and stabilization interventions on the lumbar spine, with a complete or partial facetectomy at the level of the lesion. All examined biopsy materials were divided into 4 groups depending on the grade of intervertebral disk degeneration according to Pfir-rmann: group 1 — grade II (n = 31); group 2 — grade III (n = 36); group 3 — grade IV (n = 46); group 4 — grade V (n = 32).
An increase in volume fraction of chondrocytes in intermediate zone was established. The cellular density growth was associated with an increase in the proportion of 3- and 4-cell lacunae and the emergence of 4-6 cell clusters at the advanced stages of disk degeneration. At the same time, the chondrocyte volume fraction in the superficial zone decreased significantly.
The revealed nature and dynamics of changes in the facet joints can be used in the interpretation of neuroimaging results for more reasonable choice of fixation techniques of a spinal motion segment in degenerative diseases of lumbar spine.
About the Authors
V. P. Konev
Omsk State Medical University
Russian Federation
Russian Federation
Konev Vladimir Pavlovich — Dr. Sci. (Med.), Professor, Head, Department of Forensic Medicine and Law.
12, Lenina str., Omsk, 644099
A. E. Krivoshein
Omsk State Medical University; Clinical Medical and Surgical Center
Russian Federation
Russian Federation
Krivoshein Artem Evgenyevich — Cand. Sci. (Med.), Assistant Professor, Department of Traumatology and Orthopedics, OSMU; Scientific Director, Department of Traumatology No. 2 (Verte-brology), CMSC.
Omsk
S. V. Kolesov
Priorov National Medical Research Center of Traumatology and Orthopedics
Russian Federation
Russian Federation
Kolesov Sergey Vasilyevich — Dr. Sci. (Med.), Professor, Head, Department of Spine Pathology.
Moscow
S. N. Moscovsky
Omsk State Medical University
Russian Federation
Russian Federation
Moscovsky Sergey Nikolayevich — Candidate Sci. (Med.), Assistant Professor, Department of Forensic Medicine and Law.
Omsk
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Review
For citations:
Konev V.P., Krivoshein A.E., Kolesov S.V., Moscovsky S.N. The nature and dynamics of the facet joints changes in varying grades of intervertebral disc degeneration. Journal of Siberian Medical Sciences. 2020;(4):90-98.
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