Morphological assessment of the mucous membranes of the bladder and vagina in chronic cystitis in women
Abstract
The study involved 107 women aged 20 to 52 years with chronic recurrent cystitis (57 of them with leukoplakia) developing under conditions of a pathogenic and/or opportunistic infection. All patients underwent a conventional clinical and instrumental examination. Biopsy samples for culture-based and microscopic examination were taken from the area of the Pawlik’s trigone of the vagina and the Lieutaud’s trigone of the urinary bladder, in case of leukoplakia — from the fi eld of visually healthy tissue. The carried out cytomorphological analysis and assessment of pathological processes in the adjacent tissues suggest that the infection from the vagina penetrates through the intersynaptic clefts, interstitial cell nests, the blood and lymphatic microcirculatory system into the bladder, causing cystitis inherent changes — from initial morphological forms to rough ones, up to leukoplakia. A complex of clinical, functional and pathomorphological changes that fi t into the framework of the chronic cystovaginitis concept was identified.
About the Authors
I. I. Tityaev
City Clinical Hospital No. 1
Russian Federation
Russian Federation
Tityaev Igor I.— Dr. Sci. (Med.), Professor, Urologist
6, Zalesskogo str., Novosibirsk, 630047
K. V. Udalov
City Clinical Hospital No. 1;
Novosibirsk State Medical University
Russian Federation
Russian Federation
Udalov Konstantin V.— Assistant, Department of Urology, Novosibirsk State Medical Head, Department of Oncourology, City Clinical Hospital No. 1
Novosibirsk
B. I. Aizikovich
Novosibirsk State University
Russian Federation
Russian Federation
Aizikovich Boris I. — Dr. Sci. (Med.), Professor, Department of Fundamental Medicine, Novosibirsk State University
Novosibirsk
S. V. Savchenko
Novosibirsk State Medical University
Russian Federation
Russian Federation
Savchenko Sergey V.— Dr. Sci. (Med.), Professor, Department of Forensic Medicine
Novosibirsk
D. V. Morozov
City Clinical Hospital No. 1
Russian Federation
Russian Federation
Morozov Dmitriy V. — Cand. Sci. (Med.), Head, Department of Pathology and Anatomy
Novosibirsk
References
1. Alidjanov J.F., Abdufattaev U.A., Makhsudov S.A. et al. (2016). The acute cystitis symptom score for patientreported outcome assessment. Urol. Int., 97, 402–409.
2. Lüthje P., Brauner A. (2016). Novel strategies in the prevention and treatment of urinary tract infections. Pathogens, 5 (1): 13.
3. Kranz J., Schmidt S., Lebert C. et al. (2017). Epidemiology, diagnostics, therapy, prevention and management of uncomplicated bacterial outpatient acquired urinary tract infections in adult patients: update 2017 of the interdisciplinary AWMF S3 guideline. Urologe, 56, 746–758. In German.
4. Wagenlehner F.M., Abramov-Sommariva D., Höller M., Steindl H., Naber K.G. (2018). Non-antibiotic herbal therapy (BNO 1045) versus antibiotic therapy (Fosfomycin Trometamol) for the treatment of acute lower uncomplicated urinary tract infections in women: a double-blind, parallel-group, randomized, multicentre, non-inferiority phase III trial. Urol. Int., 101, 327–336. doi: 10.1159/000493368.
5. Ny S., Edquist P., Dumpis U. et al. (2019). Antibiotic resistance of Escherichia coli isolates from outpatient urinary tract infection in women in six European countries including Russia. J. Glob. Res., 17, 25–34. doi: 10.1016/j.jgar.2018.11.004.
6. Guglietta A. (2017). Recurrent urinary tract infections in women: risk factors, etiology, pathogenesis and prophylaxis. Future Microbiol., 12 (3), 239–246.
7. Droupy S. (2017). The therapeutic approach to different forms of cystitis: impact on public health. Urologia, 84 (1), 8–15. doi: 10.5301/uj.5000262.
8. Perrotta C., Aznar M., Mejia R., Albert X., Ng C.W. (2008). Oestrogens for preventing recurrent urinary tract infection in postmenopausal women. Cochrane Database Syst. Rev., 2: CD005131.
9. Foxman B., Buxton M. (2013). Alternative approaches to conventional treatment of acute uncomplicated urinary tract infection in women. Curr. Infect. Dis. Rep., 15, 124–129.
Review
For citations:
Tityaev I.I., Udalov K.V., Aizikovich B.I., Savchenko S.V., Morozov D.V. Morphological assessment of the mucous membranes of the bladder and vagina in chronic cystitis in women. Journal of Siberian Medical Sciences. 2021;(2):56-64. (In Russ.)
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