Revisiting the early diagnosis of Q fever (literature review)
https://doi.org/10.31549/2542-1174-2023-7-2-138-149
Abstract
Based on literature data, the review presents current information on a wide range of clinical manifestations of Q fever, as well as on laboratory methods for diagnosing the disease. Q fever is a zoonotic disease with a variety of transmission routes of its pathogen – Coxiella burnetii. The main carriers of coxiellas are ixodid ticks; in anthropogenic foci their hosts are domestic and livestock animals. The Q fever foci in the Novosibirsk region were found back in the 90s of the last century, however, laboratory diagnostics was not performed over the past two decades. Due to the polymorphism of clinical symptoms, the clindisease has no pathognomonic signs. The main manifestations of acute Q fever are fever, myalgias, pneumonia. Confirmation of the diagnosis is possible only if genetic and serological markers of the causative agent Coxiella burnetii are identified, which makes it possible to differentiate Q fever from other infections and prescribe appropriate therapy in a timely manner.
About the Authors
A. N. Vyazhevich
Novosibirsk State Medical University; City Infectious Disease Clinical Hospital No. 1
Russian Federation
Russian Federation
Anna N. Vyazhevich – Assistant, Department of Infectious Diseases; Infectious Disease Physician
Novosibirsk
E. I. Krasnova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Elena I. Krasnova – Dr. Sci. (Med.), Professor, Head, Department of Infectious Diseases
Novosibirsk
N. I. Khokhlova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Natalya I. Khokhlova – Cand. Sci. (Med.), Associate Professor, Department of Infectious Diseases
Novosibirsk
V. V. Provorova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Veronika V. Provorova – Cand. Sci. (Med.), Associate Professor, Department of Infectious Diseases
Novosibirsk
V. G. Kuznetsova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Vera G. Kuznetsova – Dr. Sci. (Med.), Professor, Department of Infectious Diseases
52, Krasny prosp., Novosibirsk, 630091
L. L. Pozdnyakova
City Infectious Disease Clinical Hospital No. 1
Russian Federation
Russian Federation
Larisa L. Pozdnyakova – Cand. Sci. (Med.), Infectious Disease Physician, Chief Physician
Novosibirsk
E. I. Bondarenko
State Research Center of Virology and Biotechnology VECTOR
Russian Federation
Russian Federation
Evgeniy I. Bondarenko – Cand. Sci. (Med.), Researcher, Polymerase Chain Reaction Laboratory
Koltsovo village, Novosibirsk region
Ya. S. Ulyanova
Novosibirsk State Medical University; City Infectious Disease Clinical Hospital No. 1
Russian Federation
Russian Federation
Yana S. Ulyanova – Infectious Disease Physician, Deputy Chief Physician; Assistant, Department of Infectious Diseases
Novosibirsk
Т. А. Kolpakova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Tatiana A. Kolpakova – Dr. Sci. (Med.), Professor, Department of Phthisiopulmonology
Novosibirsk
L. V. Poddubnaya
Novosibirsk State Medical University
Russian Federation
Russian Federation
Ludmila V. Poddubnaya – Dr. Sci. (Med.), Professor, Head, Department of Phthisiopulmonology
Novosibirsk
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Review
For citations:
Vyazhevich A.N., Krasnova E.I., Khokhlova N.I., Provorova V.V., Kuznetsova V.G., Pozdnyakova L.L., Bondarenko E.I., Ulyanova Ya.S., Kolpakova Т.А., Poddubnaya L.V. Revisiting the early diagnosis of Q fever (literature review). Journal of Siberian Medical Sciences. 2023;(2):138-149. (In Russ.) https://doi.org/10.31549/2542-1174-2023-7-2-138-149
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