Anticoagulant activity of Nonea rossica Steven herb
https://doi.org/10.31549/2542-1174-2023-7-4-68-76
Abstract
I n t r o d u c t i o n . Anticoagulants are included in the treatment protocols for several cardiovascular diseases. Nonea rossica Steven is of scientific interest as a source of biologically active compounds with the properties of an indirect anticoagulant.
A i m . Study of anticoagulant activity of total extracts from Nonea rossica Steven herb.
M a t e r i a l s a n d m e t h o d s . A dry extract was obtained from the herb using 70% ethanol, then the extractant was removed. The anticoagulant effect was studied in vivo (36 male Wistar rats) using a prothrombin time test. As a reference drug, warfarin was used in doses recommended by the patient information leaflet.
R e s u l t s . The extract studied at a dose of 1.7 g/kg showed anticoagulant activity comparable to the reference drug (prothrombin time is 31.3 ± 1.27 and 33.42 ± 1.33 s, respectively).
C o n c l u s i o n . Nonea rossica Steven is a promising plant for practical as an indirect anticoagulant.
About the Authors
O. M. Dolganova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Olga M. Dolganova – Cand. Sci. (Med.), Associate Professor, Department of Medical Chemistry
Novosibirsk
V. V. Velichko
Novosibirsk State Medical University
Russian Federation
Russian Federation
Victoria V. Velichko – Cand. Sci. (Pharmaceut.), Head, Department of Pharmacognosy and Botany
52, Krasny prosp., Novosibirsk, 630091
M. E. Kartashova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Marina E. Kartashova – Post-Graduate Student, Lecturer, Department of Pharmacognosy and Botany
Novosibirsk
K. I. Ershov
Novosibirsk State Medical University
Russian Federation
Russian Federation
Konstantin I. Ershov – Cand. Sci. (Bio.), Associate Professor, Department of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine
Novosibirsk
D. S. Kruglov
Novosibirsk State Medical University
Russian Federation
Russian Federation
Dmitry S. Kruglov – Cand. Sci. (Tech.), Associate Professor, Department of Pharmacognosy and Botany
Novosibirsk
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Review
For citations:
Dolganova O.M., Velichko V.V., Kartashova M.E., Ershov K.I., Kruglov D.S. Anticoagulant activity of Nonea rossica Steven herb. Journal of Siberian Medical Sciences. 2023;(4):68-76. (In Russ.) https://doi.org/10.31549/2542-1174-2023-7-4-68-76
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