Audiovisual and magnetic brain stimulation in rehabilitation of post-stroke cognitive impairment (literature review)
https://doi.org/10.31549/2542-1174-2025-9-3-109-127
Abstract
Stroke is a pressing medical problem that causes signifi cant socio-economic losses. Post-stroke cognitive impairment negatively aff ects rehabilitation outcomes, increases the likelihood of recurrent stroke and premature death. In the management of post-stroke cognitive impairment, signifi cant attention is paid to the use of non-invasive physical brain stimulation – audiovisual stimulation, transcranial magnetic stimulation (TMS) and transcranial direct or alternating current electrical stimulation. The mechanism of audiovisual impact on the state of the brain is due to the formation of a dominant rhythm of electrocortical activity, the biological eff ects of weak magnetic fi elds are determined by chemical processes responsible for enzymatic DNA synthesis, which can stimulate processes of neuroplasticity in stroke patients and aff ect the cognitive functions. The most promising in the treatment of post-stroke cognitive impairment are considered to be modern directions of TMS: high-frequency or low-frequency repetitive TMS (rTMS), intermittent theta pulse stimulation, which have demonstrated safety and eff ectiveness. In recent years, in the set of rehabilitation programs for the recovery of poststroke cognitive defi cit multimodal interventions have been widely used, including physical exercises, walking, cognitive and aerobic training.
The data presented in the review indicate that the inclusion of transcranial low- and high-intensity pulsed magnetic fi eld therapy, audiovisual stimulation of brain structures into rehabilitation programs for post-ischemic stroke patients contributes to the improvement of attention, speech, gnosis, delayed memory and orientation, and increases the functional level of the central nervous system.
About the Authors
V. А. DrobyshevRussian Federation
Viktor A. Drobyshev – Dr. Sci. (Med.), Professor, Department of Hospital Therapy and Medical Rehabilitation
52, Krasny prosp., Novosibirsk, 630091
L. А. Shchepankevich
Russian Federation
Larisa A. Shchepankevich – Dr. Sci. (Med.), Associate Professor, Head, Department of Neurology
52, Krasny prosp., Novosibirsk, 630091
D. V. Belik
Russian Federation
Dmitry V. Belik – Dr. Sci. (Tech.), Director Generale
Novosibirsk
А. V. Shekalov
Russian Federation
Alexander V. Shekalov – Director of Scientifi c and Technical Activities
Novosibirsk
S. G. Abramovich
Russian Federation
Stanislav G. Abramovich – Dr. Sci. (Med.), Professor, Head, Department of Physical and Rehabilitation Medicine
Irkutsk
L. G. Agasarov
Russian Federation
Lev G. Agasarov – Dr. Sci. (Med.), Professor, Chief Researcher
Moscow
L. А. Shpagina
Russian Federation
Lyubov A. Shpagina – Dr. Sci. (Med.), Professor, Head, Department of Hospital Therapy and Medical Rehabilitation
52, Krasny prosp., Novosibirsk, 630091
M. S. Ponomareva
Russian Federation
Maria S. Ponomareva – Senior Laboratory Assistant, Department of Neurology
52, Krasny prosp., Novosibirsk, 630091
S. А. Karmanovskaya
Russian Federation
Svetlana A. Karmanovskaya – Dr. Sci. (Med.), Associate Professor, Department of Hospital Therapy and Medical Rehabilitation
52, Krasny prosp., Novosibirsk, 630091
References
1. Powers W.J., Rabinstein A.A., Ackerson T. et al. 2018 Guidelines for the early management of patients with acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2018;49(3):e46-e110. DOI: 10.1161/STR.0000000000000158.
2. Küçükdeveci A.A., Stibrant Sunnerhagen K., Golyk V. et al. Evidence-based position paper on Physical and Rehabilitation Medicine professional practice for persons with stroke. The European PRM position (UEMS PRM Section). Eur. J. Phys. Rehabil. Med. 2019;54(6):957-970. DOI: 10.23736/s1973-9087.18.05501-6.
3. Winstein C.J., Stein J., Arena R. et al. Guidelines for adult stroke rehabilitation and recovery: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016;47(6):e98-e169. DOI: 10.1161/STR.0000000000000098.
4. Gong Y., Long X.M., Xu Y. et al. Effects of repetitive transcranial magnetic stimulation combined with transcranial direct current stimulation on motor function and cortex excitability in subacute stroke patients: A randomized controlled trial. Clin. Rehabil. 2021; 35(5):718-727. DOI: 10.1177/0269215520972940.
5. Hordacre B., Comacchio K., Williams L., Hillier S. Repetitive transcranial magnetic stimulation for poststroke depression: a randomised trial with neurophysiological insight. J. Neurol. 2021;268(4):1474-1484. DOI: 10.1007/s00415-020-10315-6.
6. Wang Y., Wang L., Ni X. et al. Efficacy of repetitive transcranial magnetic stimulation with different application parameters for post-stroke cognitive impairment: a systematic review. Front. Neurosci. 2024;18:1309736. DOI: 10.3389/fnins.2024.1309736.
7. Tan E., Troller-Renfree S., Morales S. et al. Theta activity and cognitive functioning: Integrating evidence from resting-state and task-related developmental electroencephalography (EEG) research. Dev. Cogn. Neurosci. 2024;67:101404. DOI: 10.1016/j.dcn.2024.101404.
8. Fischer M., Moscovitch M., Alain C. A systematic review and meta-analysis of memory-guided attention: Frontal and parietal activation suggests involvement of fronto-parietal networks. Wiley Interdiscip. Rev. Cogn. Sci. 2021;12(1):e1546. DOI: 10.1002/wcs.1546.
9. Campbell B.C.V., Khatri P. Stroke. Lancet. 2020;396(10244):129-142. DOI: 10.1016/S0140-6736(20)31179-X.
10. Eschmann K.C.J., Mecklinger A. Improving cognitive control: Is theta neurofeedback training associated with proactive rather than reactive control enhancement? Psychophysiology. 2022;59(5):e13873. DOI: 10.1111/psyp.13873.
11. Harvey R.L., Edwards D., Dunning K. et al. Randomized sham-controlled trial of navigated repetitive transcranial magnetic stimulation for motor recovery in stroke // Stroke. 2018;49(9):2138-2146. DOI: 10.1161/STROKEAHA.117.020607.
12. Al-Shargie F., Katmah R., Tariq U. et al. Stress management using fNIRS and binaural beats stimulation. Biomed. Opt. Express. 2022;13(6):3552-3575. DOI: 10.1364/BOE.455097.
13. Bavafa A., Foroughi A., Jaberghaderi N., Khazaei H. Investigating the effi cacy of theta binaural beat on the absolute power of theta activity in primary insomniacs. Basic. Clin. Neurosci. 2023;14(3):331-340. DOI: 10.32598/bcn.2021.2162.1.
14. Gkolias V., Amaniti A., Triantafyllou A. et al. Minimal eff ects of binaural auditory beats for subclinical insomnia. Does pain play a role? J. Clin. Psychopharmacol. 2020;40(3):320-321. DOI: 10.1097/JCP.0000000000001212.
15. Halpin S.J., Casson A.J., Tang N.K.Y. et al. A feasibility study of pre-sleep audio and visual alpha brain entrainment for people with chronic pain and sleep disturbance. Front. Pain Res. (Lausanne).2023;4:1096084. DOI: 10.3389/fpain.2023.1096084.
16. Yatsenko M.V., Kaygorodova N.Z. Infl uence of color photostimulation on coordination of movements. Health, Physical Culture and Sports. 2019;4 (15):329-335. (In Russ.)
17. Busch N., Geyer T., Zinchenko A. Individual peak alpha frequency does not index individual diff erences in inhibitory cognitive control. Psychophysiology. 2024;61(8):e14586. DOI: 10.1111/psyp.14586.
18. Gaurav G., Anand R.S., Kumar V. EEG based cognitive task classifi cation using multifractal detrended fl uctuation analysis. Cogn. Neurodyn. 2021;15(6):999-1013. DOI: 10.1007/s11571-021-09684-z.
19. Pfeiff er M., Kübler A., Hilger K. Modulation of human frontal midline theta by neurofeedback: A systematic review and quantitative meta-analysis. Neurosci. Biobehav. Rev. 2024;162:105696. DOI: 10.1016/j.neubiorev.2024.105696.
20. Tsai P.Y., She H.C., Chen S.C. et al. Eye fi xation-related fronto-parietal neural network correlates of memory retrieval. Int. J. Psychophysiol. 2019;138:57-70. DOI: 10.1016/j.ijpsycho.2019.02.008.
21. Belik D.V., Dmitriev N.A., Pustovoy S.A., Zinevskaya M.S. The technical system to stimulate the brain and memory fi elds of the hippocampus with the aim of rehabilitation after stroke. Biotechnosfera. 2015;6(42):20- 25. (In Russ.)
22. Khaervarina A.F., Matveyeva L.M., Muftakhina R.M. et al. Audiovisual correction of psychoemotional status in young boxer. Human. Sport. Medicine. 2019;19(S1):36-42. DOI: 10.14529/hsm19s105. (In Russ.)
23. Sysoev V.N., Chebykina A.V., Dushkina M.A., Dergachev V.B. Evaluation of the eff ectiveness of single session audiovisual stimulation for the organism functional state’s correction. Bulletin of the Russian Military Medical Academy. 2018;20(3):128-132. (In Russ.)
24. Liu Y., Liu S., Tang C. et al. Transcranial alternating current stimulation combined with sound stimulation improves cognitive function in patients with Alzheimer’s disease: Study protocol for a randomized controlled trial. Front. Aging Neurosci. 2023;14:1068175. DOI: 10.3389/fnagi.2022.1068175.
25. Cherevaschenko L.A., Cherevaschenko I.A., Kulikov N.N. et al. Cognitive impairment in patients with chronic discirculatory encephalopathy and their correction at the resort phase. Medical News of North Caucasus. 2012;1:67-69. (In Russ.)
26. Shivakumar S., Dhilip K.S. PEMF therapy – an early adjuvant strategy in management of COVID19 patients. Research Gate. 2021. DOI: 10.13140/RG.2.2.14964.76162.
27. Horwitz A., Klemp M., Horwitz H. et al. Brain responses to passive sensory stimulation correlate with intelligence. Front. Aging Neurosci. 2019;11:201. DOI: 10.3389/fnagi.2019.0020.
28. van Lieshout E.C.C., van der Worp H.B., VisserMeily J.M.A., Dijkhuizen R.M. Timing of repetitive transcranial magnetic stimulation onset for upper limb function after stroke: a systematic review and meta-analysis. Front. Neurology. 2019;10:1269. DOI: 10.3389/fneur.2019.01269.
29. Dimulescu C., Donle L., Cakan C. t al. Improving the detection of sleep slow oscillations in electroencephalographic data. Front Neuroinform. 2024;18: 1338886. DOI: 10.3389/fninf.2024.1338886.
30. Makarov А.О., Efi mova М.Yu., Ivanov А.Yu. et al. Results of cognitive rehabilitation of elderly patients undergoing fi rst and repeat ishemic stroke. Modern Problems of Science and Education. 2016;5:45. (In Russ.)
31. Prokopenko S.V., Mozheiko E.Yu., Shvetsova I.N. Activation of sensory brain areas for recovery of cognitive functions after stroke. Doctor.ru. 2017;11(140):13-18. (In Russ.)
32. Isakova E.V., Slyunkova E.V The effi cacy of repeated courses of a multimodal stimulation program in the correction of post-stroke cognitive and emotionalbehavioral disorders: a prospective cohort study. Pharmateca. 2020;3(27):71-17. (In Russ.)
33. Zalomaeva Е.S., Ivanova P.N., Chalisova N.I. et al. Eff ects of weak static magnetic fi eld and oligopeptides on cell proliferation and cognitive functions in diff erent animal species. Technical Physics. 2020. 65(10):1585- 1590. DOI: 10.1134/S1063784220100254.
34. Chan A.K., Tang X., Mummaneni N.V. et al. Pulsed electromagnetic fi elds reduce acute infl ammation in the injured rat-tail intervertebral disc. JOR Spine. 2019;2(2):1069. DOI: 10.1002/jsp2.1069.
35. Gerasimenko M.Yu. (2015). Application of Magnetic Therapy in Treatment, Preventive and Rehabilitation programs: Clinical Recommendations. Moscow. 47 p. (In Russ.)
36. Gumarova L.Sh., Bodrova R.A., Khasanova D.R. et al. Clinical eff ectiveness of «thresholdless» low-frequency transcranial magnetic stimulation in patients with ischemic stroke. Problems of Balneology, Physiotherapy and Exercise Therapy. 2020;97(5):39-44. DOI: 10.17116/kurort20209705139. (In Russ.)
37. Di Gregorio F., La Porta F., Casanova E. et al. Effi cacy of repetitive transcranial magnetic stimulation combined with visual scanning treatment on cognitive and behavioral symptoms of left hemispatial neglect in right hemispheric stroke patients: study protocol for a randomized controlled trial. Trials. 2021;22(1):24. DOI: 10.1186/s13063-020-04943-6.
38. Hernandez-Pavon J.C., Harvey R.L. Noninvasive transcranial magnetic brain stimulation in stroke. Phys. Med. Rehab. Clin. N. Am. 2019;30(2):319-335. DOI: 10.1016/j.pmr.2018.12.010.
39. Akimzhanova A.K., Grjibovski A.M., Khaibullin T.N. et al. Eff ectifveness of transcranial magnetic stimulation in rehabilitation of stroke patients. Science & Healthcare. 2016;4:50-65. (In Russ.)
40. Dionisio A., Duarte I.C., Patricio M., Castelo-Branco M. The use of repetitive transcranial magnetic stimulation for stroke rehabilitation: a systematic review. J. Stroke Cerebrovasс. Dis. 2018;27(1):1-31. DOI: 10.1016/j.jstrokecerebrovasdis.2017.09.008.
41. Mamedova M.Yu. Effects of rhythmic transcranial and multilevel magnetic stimulation on cognitive impairments in post-stroke patients. The Bulletin of Contemporary Clinical Medicine. 2021;14(3):23- 32. DOI: 10.20969/VSKM.2021.14(3).23-32. (In Russ.)
42. Begemann M.J., Brand B.A., Ćurčić-Blake B. et al. Effi cacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis. Psychol. Med. 2020;50(15): 2465-2486. DOI: 10.1017/s0033291720003670.
43. Lebedeva D.I., Turovinina E.F., Desyatova I.E. et al. Eff ectiveness of transcranial magnetic stimulation in patients after ischemic stroke: a prospective study. Bulletin of Rehabilitation Medicine. 2023;22(4):31- 40. DOI: 10.38025/2078-1962-2023-22-4-31-40. (In Russ.)
44. Wang Y., Xu N., Wang R., Zai W. Systematic review and network meta-analysis of eff ects of noninvasive brain stimulation on post-stroke cognitive impairment. Front. Neurosci. 2022;16:1082383. DOI: 10.3389/fnins.2022.1082383.
45. Chu M., Zhang Y., Chen J. et al. Effi cacy of intermittent theta-burst stimulation and transcranial direct current stimulation in treatment of post-stroke cognitive impairment. J. Integr. Neurosci. 2022;21(5):130. DOI: 10.31083/j.jin2105130.
46. Han M., He J., Chen N. et al. Intermittent theta burst stimulation vs. high-frequency repetitive transcranial magnetic stimulation for post-stroke cognitive impairment: Protocol of a pilot randomized controlled double-blind trial. Front. Neurosci. 2023;17:1121043. DOI: 10.3389/fnins.2023.1121043.
47. Daoud A., Elsayed M., Alnajjar A.Z. et al. Effi cacy of intermittent theta burst stimulation (iTBS) on poststroke cognitive impairment (PSCI): a systematic review and meta-analysis. Neurol. Sci. 2024;45(5):2107-2118. DOI: 10.1007/s10072-023-07267-w.
Review
For citations:
Drobyshev V.А., Shchepankevich L.А., Belik D.V., Shekalov А.V., Abramovich S.G., Agasarov L.G., Shpagina L.А., Ponomareva M.S., Karmanovskaya S.А. Audiovisual and magnetic brain stimulation in rehabilitation of post-stroke cognitive impairment (literature review). Journal of Siberian Medical Sciences. 2025;(3):109-127. (In Russ.) https://doi.org/10.31549/2542-1174-2025-9-3-109-127

























