Analysis of demographic and clinical profiles of patients with hidradenitis suppurativa
https://doi.org/10.31549/2542-1174-2025-9-4-46-60
Abstract
Introduction. Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of sweat glands marked by alternating periods of improvement and flare-ups. It is a serious skin condition that profoundly affects well-being of individuals with HS.
Aim. To analyze demographic and clinical profiles of patients with HS.
Materials and methods . The demographic and clinical profiles of 200 HS patients were analyzed, potential key risk factors were identified, and treatment patterns, including medical, surgical, and combination therapies, were examined. Using a quantitative approach and SPSS version 27, statistical analyses (correlation, frequency, regression, and ANOVA) of data obtained during a standard survey were conducted.
Results . A strong association between the HS severity and clinical characteristics (HS duration, hospitalization and comorbidities), as well as potential risk factors (psychological, genetic and lifestyle influences) were determined. Also, it was shown that patterns of treatment significantly affect the symptom management and quality of life.
Conclusion. The findings underscore the need for a comprehensive understanding of demographics and clinical profiles in HS and using tailored treatment approaches to improve outcomes and quality of life of HS patients.
About the Authors
S. S. Wadhawa
Raipur Institute Of Medical Sciences
India
India
Suraj Singh Wadhawa – Clinical and Academic Dermatologist, Assistant Professor, Department Of Dermatology
Raipur, Chhattisgarh
S. Tiwari
Rewa Multispecialty Clinic
India
India
Siddhant Tiwari – MD, Clinical Dermatologist
Rewa, Madhya Pradesh
S. Agrawal
B.P. Koirala Institute of Health Sciences
Nepal
Nepal
Sudha Agrawal – MD, Professor, Department of Dermatology, Head
Buddha Road, Dharan 56700, Nepal.
References
1. Gambichler T., Hessam S., Cramer P. et al. Complete blood collection-based systemic infl ammation bio-markers for patients with hidradenitis suppurativa // J. Eur. Acad. Dermatol. Venereol. 2022;36(9):1593-1596. DOI: 10.1111/jdv.18175.
2. Campbell C., Mayatra J.M., Neve A.J. et al. Infl ammasomes: emerging therapeutic targets in hidradenitis suppurativa? // Br. J. Dermatol. 2024;191(5):670-679. DOI: 10.1093/bjd/ljae262.
3. Collier E.K., Parvataneni R.K., Lowes M.A. et al. Diagnosis and management of hidradenitis suppurativa in women // Am. J. Obstet. Gynecol. 2021;224(1):54-61. DOI: 10.1016/j.ajog.2020.09.036.
4. Sabat R., Jemec G.B., Matusiak Ł. et al. Hidradenitis suppurativa // Nat. Rev. Dis. Primers. 2020;6(1):18. DOI: 10.1038/s41572-020-0149-1.
5. Goldburg S.R., Strober B.E., Payette M.J. Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis // J. Am. Acad. Dermatol. 2020;82(5):1045-1058. DOI: 10.1016/j.jaad.2019.08.090.
6. Amat-Samaranch V., Agut-Busquet E., Vilar-rasa E., Puig L. New perspectives on the treatment of hidradenitis suppurativa // Ther. Adv. Chronic Dis. 2021;12:20406223211055920. DOI: 10.1177/20406223211055920.
7. La Padula S., Pensato R., Pizza C. et al. The thoracodorsal artery perforator fl ap for the treatment of hidradenitis suppurativa of the axilla: A prospective comparative study // Plast. Reconstr. Surg. 2023;152(5):1105-1116. DOI: 10.1097/PRS.0000000000010435.
8. Nguyen T.V., Damiani G., Orenstein L.A. et al. Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life // J. Eur. Acad. Dermatol. Venereol. 2021;35(1):50-61. DOI: 10.1111/jdv.16677.
9. Schneider-Burrus S., Kalus S., Fritz B. et al. The impact of hidradenitis suppurativa on professional life // Br. J. Dermatol. // 2023;188(1):122-130. DOI: 10.1093/bjd/ljac027.
10. Wolk K., Join-Lambert O., Sabat R. Aetiology and pathogenesis of hidradenitis suppurativa // Br. J. Dermatol. 2020;183(6):999-1010. DOI: 10.1111/bjd.19556
11. Moltrasio C., Tricarico P.M., Romagnuolo M. et al. Hidradenitis suppurativa: a perspective on genetic factors involved in the disease // Biomedicines. 2022;10(8):2039. DOI: 10.3390/biomedicines10082039.
12. van Straalen K.R., Prens E.P., Gudjonsson J.E. Insights into hidradenitis suppurativa // J. Allergy Clin. Immunol. 2022;149(4):1150-1161. DOI: 10.1016/j.jaci.2022.02.003.
13. Scala E., Cacciapuoti S., Garzorz-Stark N. et al. Hidradenitis suppurativa: where we are and where we are going // Cells. 2021;10(8):2094. DOI: 10.3390/cells10082094.
14. Krueger J.G., Frew J., Jemec G.B. et al. Hidradenitis suppurativa: new insights into disease mechanisms and an evolving treatment landscape // British J. Dermatol. 2024;190(2):149-162. DOI: 10.1093/bjd/ljad345.
15. Ballard K., Sathe N.S., Shuman V. Hidradenitis Suppurativa. StatPearls. Treasure Island: StatPearls Publishing, 2024.
16. Rosi E., Fastame M.T., Silvi G. et al. Hidradenitis suppurativa: the infl uence of gender, the importance of trigger factors and the implications for patient ha bits // Biomedicines. 2022;10(11):2973. DOI: 10.3390/biomedicines10112973.
17. Baur N. Linearity vs. circularity? On some common misconceptions on the diff erences in the research process in qualitative and quantitative research // Frontiers Educ. 2019;4:53. DOI: 10.3389/feduc.2019.00053.
18. Sürücü L., Maslakçi A. Validity and reliability in quantitative research // Business Manag. Studies. 2020;8(3):2694-2726. DOI: 10.15295/bmij.v8i3.1540.
19. Mohajan H.K. Quantitative research: A successful investigation in natural and social sciences // J. Econom. Develop. Envir. People. 2021;9(4);50-79. DOI: 10.26458/jedep.v9i4.679.
20. Lakens D. Sample size justifi cation // Collabra: Psychology. 2022;8(1):33267. DOI: 10.1525/collabra.33267.
21. Stratton S.J. Population research: convenience sampling strategies // Prehosp. Disaster Med. 2021;36(4):373-374. DOI: 10.1017/S1049023X21000649.
22. Sreekumar D. What is quantitative research? Definition, methods, types, and examples. 2023. URL: researcher.life/blog/article/what-is-quantitative-research-types-and-examples/#What_is_quantitative_research12 (дата обращения: 10.10.2025).
23. Taherdoost H. Data collection methods and tools for research; a step-by-step guide to choose data collection technique for academic and business research projects // Int. J. Acad. Res. Manag. 2021;10(1):10-38.
24. Jung Y.M. Data analysis in quantitative research // Liamputtong P. Handbook of Research Methods in Health Social Sciences. Singapore: Springer Singapore, 2019.
25. Dzwigol H. (2020). Innovation in marketing research: quantitative and qualitative analysis // Market. Manag. Innov. 2020. DOI: 10.21272/mmi.2020.1-10.
26. Nelson K., Christopher F., Milton N. Teach yourself SPSS and STATA // Int. J. Acad. Pedagog. Res. 2022;6(7):84-122.
27. Astivia O.L., Zumbo B.D. Heteroskedasticity in multiple regression analysis: What it is, How to detect it and How to solve it with applications in R and SPSS // Pract. Assess. Res. Eval. 2019;24(1):1. DOI: 10.7275/q5xr-fr95.
28. Juarros-Basterretxea J., Aonso-Diego G., Postigo Á. et al. Post-hoc tests in one-way ANOVA: The case for normal distribution // Methodology. 2024;20(2):e11721. DOI: 10.5964/meth.11721.
29. Killasli H., Sartorius K., Emtestam L., Svensson Å. 2020; Hidradenitis suppurativa in Sweden: A registry-based cross-sectional study of 13,538 patients // Dermatology. 2024;236(4):281-288. DOI: 10.1159/000505545.
30. Kjærsgaard Andersen R., Saunte S.K., Jemec G.B.E., Saunte D.M. Psoriasis as a comorbidity of hidradenitis suppurativa // Int. J. Dermatol. 2020;59(2):216-220. DOI: 10.1111/ijd.14651.
31. Özkur E., Karadağ A.S., Üstüner P. et al. Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity // Clin. Exp. Dermatol. 2021;46(3):532-540. DOI: 10.1111/ced.14478.
32. Uzunçakmak T.K.U., Özçakır E.C., Aşkın Ö., Engin B. The frequency of comorbidities and their eff ects on disease severity in hidradenitis suppurativa // J. Turk. Acad. Dermatol. 2021;15(2):44-48. DOI: 10.4274/jtad.galenos.2021.25743.
Review
For citations:
Wadhawa S.S., Tiwari S., Agrawal S. Analysis of demographic and clinical profiles of patients with hidradenitis suppurativa. Journal of Siberian Medical Sciences. 2025;(4):46-60. https://doi.org/10.31549/2542-1174-2025-9-4-46-60
Views:
12
Email this article 