Immunopathogenesis of neuroinflammation – a modern concept (literature review)
https://doi.org/10.31549/2542-1174-2026-10-1-157-169
Abstract
Neuroinflammation is a condition characterized by a wide range of differences both in the cellular elements involved in this process (microglia, astrocytes) and in its pathogenesis as a whole. The lack of consensus on the pathogenetic models of neuroinflammation only highlights the insufficient study of this pathological phenomenon. This review examines the characteristics of neuroinflammation as a phenomenon using infectious diseases of the central nervous system, such as meningitis. Despite the specific peculiarities of neuroinflammation itself, its effector mechanisms involve the same cytokines as those found in “classical” inflammation (IL-6, IL-8, IL-1β, TNF-α, MCP-1, IFN-γ, etc.). This allows these molecules to be considered as potential targets, enabling the prevention of both acute inflammation and chronic processes associated with long-term neurological and cognitive impairment.
About the Authors
G. S. Karpovich
Novosibirsk State Medical University ; Children’s City Clinical Hospital No. 3
Russian Federation
Russian Federation
Gleb S. Karpovich – Cand. Sci. (Med.), Assistant, Department of Infectious Diseases; nfectious Diseases Physician, Head of the Children’s Infectious Diseases Department No. 1
52, Krasny prosp., Novosibirsk, 630091
S. S. Andreev
Novosibirsk State Medical University
Russian Federation
Russian Federation
Semyon S. Andreev – Medical Resident, Department of Pediatrics
Novosibirsk
I. V. Kuimova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Irina V. Kuimova – Dr. Sci. (Med.), Professor, Department of Infectious Diseases
Novosibirsk
О. О. Obukhova
Federal Research Center for Fundamental and Translational Medicine
Russian Federation
Russian Federation
Olga O. Obukhova – Dr. Sci. (Med.), Chief Researcher, Head, Laboratory of Immunology
Novosibirsk
T. I. Ryabichenko
Federal Research Center for Fundamental and Translational Medicine
Russian Federation
Russian Federation
Tatiana I. Ryabichenko – Dr. Sci. (Med.), Leading Researcher, Laboratory of Immunology
Novosibirsk
V. F. Zalyalov
Children’s City Clinical Hospital No. 3
Russian Federation
Russian Federation
Valentin F. Zalyalov – Pediatrician
Novosibirsk
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Review
For citations:
Karpovich G.S., Andreev S.S., Kuimova I.V., Obukhova О.О., Ryabichenko T.I., Zalyalov V.F. Immunopathogenesis of neuroinflammation – a modern concept (literature review). Journal of Siberian Medical Sciences. 2026;(1):157-169. (In Russ.) https://doi.org/10.31549/2542-1174-2026-10-1-157-169
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