GROWTH PROMOTING FACTOR OF ENDOTHELIUM OF VESSELS: BIOLOGICAL PROPERTIES AND PRACTICAL VALUE (LITERATURE REVIEW)
Abstract
The main data on growth promoting factor of endothelium of vessels are presented in the literature review (vascular endothelial growth factor, VEGF) and spheres of its clinical application. Physiological and pathological methods of vessels formation and factors of angiogenesis regulation are considered in the article. The main VEGF properties and its receptors, their role in regulation of vascular growth in norm are described and at development of malignant neoplasms and retina diseases. Data on the preparations inhibiting the VEGF-mediated angiogenesis are generalized. Some directions of further development of anti-angiogenic therapy are specified.
About the Authors
N. L. Svetozarskiy
SBHE «Nizhny Novgorod regional hospital n. a. N. A. Semashko»
Russian Federation
Russian Federation
A. A. Artifeksova
SBHE NR «Medical information and analysis center»
Russian Federation
Russian Federation
S. N. Svetozarskiy
FBHE «Privolzhsky regional medical center» Federal Medical Biological Agency
Russian Federation
Russian Federation
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Review
For citations:
Svetozarskiy N.L., Artifeksova A.A., Svetozarskiy S.N. GROWTH PROMOTING FACTOR OF ENDOTHELIUM OF VESSELS: BIOLOGICAL PROPERTIES AND PRACTICAL VALUE (LITERATURE REVIEW). Journal of Siberian Medical Sciences. 2015;(5):24.
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