ELECTRON-BEAM MODIFICATION OF CORONARY STENTS WITH MEDICINAL COATING
Abstract
Possibility of modification of eluting-system by means of radiation of stent with medicinal coating with stream of accelerated electrons for the purpose of prolonged release of anti-proliferative medicine from all mass of copolymeric matrix is investigated in the presented research. It is shown that it is possible to improve kinetic parameters of extraction of anti-proliferative medicine from coronary stent by means of technology of electron-beam modification. Profiles of chromatograms testify to chemical integrity of rapamicine and safety of stent.
About the Authors
P. G. Madonov
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
A. V. Dubrovin
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
P. N. Miroshnikov
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
S. V. Mishenina
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
K. I. Ershov
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
S. V. Pozdnyakova
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
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Review
For citations:
Madonov P.G., Dubrovin A.V., Miroshnikov P.N., Mishenina S.V., Ershov K.I., Pozdnyakova S.V. ELECTRON-BEAM MODIFICATION OF CORONARY STENTS WITH MEDICINAL COATING. Journal of Siberian Medical Sciences. 2015;(5):52.
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