Genetic markers of cardiovascular risk in patients with handarm vibration syndrome combined with arterial hypertension
Abstract
We investigated polymorphism of genes of endothelin I (EDN1), endothelial NOsynthase (NOS3(e)), plasminogen activator type 1 (PAI1) in patients suffered from handarm vibration syndrome (HAVS), arterial hypertension (АH), and combined course of HAVS and AH. In most cases we revealed pathological variants of genes of endothelin I, endothelial NOsynthase, and plasminogen activator type 1 taking part in regulation of endothelium and systemic hemostasis function. This fact allows to consider such gene pathology as early markers of higher risk of thrombogenic and thrombophilic disorders.
About the Authors
L. A. Shpagina
Novosibirsk State Medical University; City Clinical Hospital No. 2, Novosibirsk
Russian Federation
Russian Federation
O. N. Gerasimenko
Novosibirsk State Medical University; City Clinical Hospital No. 2, Novosibirsk
Russian Federation
Russian Federation
Z. K. Chachibaya
City Clinical Hospital No. 2, Novosibirsk
Russian Federation
Russian Federation
V. A. Drobyshev
Novosibirsk State Medical University; City Clinical Hospital No. 2, Novosibirsk
Russian Federation
Russian Federation
G. V. Kuznetsova
City Clinical Hospital No. 2, Novosibirsk
Russian Federation
Russian Federation
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Review
For citations:
Shpagina L.A., Gerasimenko O.N., Chachibaya Z.K., Drobyshev V.A., Kuznetsova G.V. Genetic markers of cardiovascular risk in patients with handarm vibration syndrome combined with arterial hypertension. Journal of Siberian Medical Sciences. 2017;(1):29-31.
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