Posttransplantation diabetes mellitus

The objective of the study is the investigating of incidence and effect of clinical peculiarities and the type of immune suppression therapy on the onset of diabetes mellitus in recipients of kidney transplant (RKT) being followed up in Novosibirsk Regional Nephrology Center. Posttransplantation diabetes mellitus (PTDM) according to KDIGO guidelines was diagnosed in 8 % of cases (17 patients: 10 males and 7 females at mean age of 49.4 ± 12.4) of 226 RKT. All the patients were given calcinuerin inhibitors (cyclosporine A - 9 patients and tacrolimus - 8 patients). The clinical peculiarities of patients’ group with PTDM are the prevalence of individuals above 40 having obtained a transplant from a deceased donor, and in most of cases having nutritive status disturbances to the extent of obesity. The correlation between the rise of body mass index and female sex claims extra attention to the monitoring of carbohydrate metabolism in this group of RKT. The prevalence of application rate of tacrolimus in patients with PTDM was not revealed. The integrated assessment of risk factors in the onset of diabetes mellitus in RKT is necessary.

posttransplantation diabetes mellitus, kidney transplantation, recipients of kidney transplant, risk factors, obesity, overweight, cyclosporine A, tacrolimus, calcinuerin inhibitors, posttransplantation diabetes mellitus therapy

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