INFLUENCE OF EXTRACTS OF BIRCH BARK ON MORPHOLOGICAL CHANGES OF THE LIVER AT RATS AT INTRODUCTION OF TETRACHLORMETHANE

Abstract

Hepatoprotective effect of aqueous-alcoholic extracts received from the raw materials of birch bark which are previously dispersed with a size of particles of 0,1-0,3 mm (DBBE) and native birch barks of (NBBE) is studied. Animals were divided into 5 groups on 10 individuals in everyone. Group 1 - intact; 2 - ССL₄ (negative control); animal of the 3^rd, 4^th groups before introduction of ССL₄ previously within 5 days once abdominally entered DBBE, NBBE in a dose of 100 mg/kg, animal the 5^th group comparisons injected a medicine karsit (JSC Sofarm, Bulgaria) in a dose of 100 mg/kg. 50% ССL₄ Solutio oleosa was entered on the 6^th day abdominally in a dose of 0,2 ml / 100; on the 1^st, 4^th and 7^th day after introduction of ССL₄ the animals were brought out of experiment. The obtained data testify to ability of DBBE to stimulate reparative processes in parenchyma of rats’ liver more in comparison with karsil and NBBE.