Thrombophilia markers (rising of activity of the VIII coagulation factor, decrease of the activity of protein C) and endothelial dysfunction (rising of activity of von Willebrand factor, contents of glycosaminoglycans in blood, and microalbuminuria) are revealed at the prolonged technogenic impact of the dust factor in workers of the dust hazardous jobs. The revealed markers of thrombophilia and endothelial dysfunction correlate with degree of fibrogenity of dust aerosols in the workers contacting with highly fibrogenic and mild fibrogenic dust aerosols.

We have examined 45 men and women at the age of 45 to 59 with osteoarthritis of the knee joints complained of a pain syndrome and limitation of motion in the lower extremities. All patients were divided into 3 groups: in the first group the basic medical treatment was supplemented with ultraphonophoresis of chitosan gel Viprazan with adder venom on the affected joints; in the second group it was carried out placebo procedure of ultraphonophoresis; in the third group the basic treatment was supplemented with application of Viprazan gel on painful zones during three weeks. Based on the research findings we have established that introduction by ultrasound of the gel Viprazan in circumarticular tissues promotes the decrease of indicators of the pain, constraint and functional insufficiency. According to WOMAC questionnaire the indicators of the pain, constraint and functional insufficiency were decreased 1.3 times, and total index - 1.2 times. Upon completion of a therapeutic course in patients of the first group it was noted the increase of degree of restoration of function of a joint up to 84.2% and an index of efficiency of microcirculation 2.1 times that was not observed in the placebo and comparison groups.

We performed an open controlled trial of efficiency and the safety of Ovariamin^® drug in treatment of menstrual disorders. The research included 33 patients with menstrual disorder which were divided into 2 groups: the 1st group - menstrual disorders /ICD10/N91. The absent scanty and infrequent menstruation (n = 17); the 2nd group - menstrual disorders /ICD10/ N92. Abundant, frequent and irregular menstruations (n = 16). The analysis of clinical efficiency of administration of Ovariamin^® drug in 3 months showed the following: normalization of menstrual cycle in the 1st group was registered in 52.9% of patients, in the 2nd group - in 62.5%; decrease of menstrual pain was registered in 52.9% in the 1st group and in 62.5% in the 2nd group. Satisfaction of patients in the end of the therapy was revealed in 88.2% in the 1st group, and in 93.8% in the 2nd group respectively; efficiency in maintenance of regular menstrual cycle in the next 6 months after treatment was revealed in 76.5% of patients of the 1st group, and in 75% of the 2nd group of patients.

Results of treatment of tuberculosis (TB) depend on the promptness with which a diagnosis is made. We examined 151 patients for the purpose of studying the opportunities of modern ultrasonography (US) in diagnostics of prostate tuberculosis (PTB). We assessed hemodynamics and vascularization of prostate (P) in all patients by means of colorflow duplex scanning. Informational value of prostate biopsy in diagnostics of prostate tuberculosis were obtained in 26 patients. Acute depression of peak, diastolic, average linear volume rates of blood flow, decrease of density of vascular plexus both in central and in peripheric gland zones were revealed at PTB. Among 12 patients with already determined PTB the signs of specific inflammation are revealed in one patient to whom was performed biopsy within the first month of treatment. Also one patient had PTB among the other 14 patients. PTB definition at early stage is complicated due to absence of pathognomonic symptoms and low degree of bacterioexcretion. US and P biopsy allows improving early diagnostics.

The principal method for early diagnostics of cardiac tumors is echocardiography. Transesophageal echocardiography allows to determine more accurately localization of the growth, structure and flexibility, and also the degree of obstruction of AVvalves. We demonstrate a clinical case of leiomyosarcoma of the right atrium, its clinical manifestations were cardiac insufficiency, cardiac arrhythmia and pericardial effusion. Difficulties in diagnostics were connected with nonspecific complaints due to tumor localization and infiltration with tumoral tissue into the cardiac structures. Our clinical case is of interest because of rarity of pathology, difficulty of intravital diagnostics of disease and interpretation of nonspecific clinical picture.

Prevalence of acute intestinal infections motivated this research. Cases of intestinal infection at a stationary stage of treatment were analysed in unit of intestinal infection in Infectious Clinical Hospital No. 1 n.a. D.M. Dalmatov in Omsk during the period from 2013 to 2015. Clinical implications of gastroenterocolitis were registered at every second patient with acute intestinal infection, some patients asked for a medical care in late terms. 10.6% of patients have had the virus etiology of gastroenterocolitis, bacteriological etiology was revealed in 2.6% of patients ( Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus ). The rotavirus infection was more often registered in young people (35.4 ± 8.7 years) with implications of gastroenteritis (37.3%), mainly of moderate severity (82.6%). Salmonellosis appeared in 9.1% of cases with bacteriological verification of Salmonella enteritidis in 86.7% of patients, Salmonella typhimurium - in 8.3%, Salmonella infantis - in 0.8%. More often implications of salmonellosis were registered among the men with a syndrome of gastroenterocolitis of moderate severity who got sick after the use of crude eggs. Acute dysentery and alimentary toxic infection was registered seldom. Every second patient left inpatient department willfully upon application. Thus, the intense situation on a disease of salmonellosis and rotavirus infection remained unchanged in the Omsk region in 2013-2015, however diagnostics of acute intestinal infections was complicated seeing acute inpatient stay in unit that did not allow conducting full examination.

Development of tuberculosis is caused by many reasons, but the main is depression of efficiency of functioning of the immune system. The purpose of the work was to identify the frequency of occurrence of alleles and genotypes of TLR2 (Arg753Gln), TLR3 (Phe412Leu), TLR4 (Asp299Gly), TLR6 (Ser249Pro) genes in patients suffering from tuberculosis. The research is performed on the basis of the analysis of clinical findings of 120 patients suffering from tuberculosis and 30 healthy peoples. For studying of a polymorphism of genes of Tolllike receptors (TLRs) we used the method of specific allele polymerase chain reaction with electrophoretic detection. Crucial importance for development of small forms and infiltrative tuberculosis has genetic predisposition in the form of a carriage of mutant genotypes of TLR3 (Phe412Leu) and TLR6 (Ser249Pro) genes. At the same time in pathogenesis of disseminated tuberculosis an important role is played by such factors as an alcoholism, an abuse of narcotics, contact to extractors, etc. The influence of external environment and genetic predisposition in the form of mutant variant of a polymorphism of a gene of TLR6 (Ser249Pro) are characterized by the fibrous and cavernous tuberculosis. The risk ratio of development of tuberculosis in carriers of mutant variants of polymorphism of TLR3 (Phe412Leu) and TLR6 (Ser249Pro) genes is higher in comparison with other variants of polymorphism of the same and other genes.

The level of Ddimer in the blood was determined in 36 patients with basal cell skin cancer. The analysis was made before the surgical treatment, on the first postoperative day, on the third, fifth, seventh, and tenth postoperative days, and in 18 months after the operation. For comparison, the blood Ddimer level was determined in 17 relatively healthy volunteers of the same age and sex (comparison group 1), and in 20 patients operated on for skin fibroma (comparison group 2) of the same age and sex as the patients in the main group. In patients with basal cell skin cancer the blood Ddimer level was elevated before the start of surgical treatment. On the first postoperative day the level increased sharply, then it gradually decreased, but did not restored to normative values, and it was elevated both in the immediate and in the remote postoperative period. The absence of a return to the normal level of Ddimer in the blood in the immediate and remote postoperative periods in patients with basal cell skin cancer indicates disturbances of rheological blood properties in this category of patients.

The aim of our research is to choose and justify the method of bacterial purification of hormonal substances of active ingredients of betamethasone dipropionate and hydrocortisoni acetas at developing of the most acceptable ways of receiving sterile prepared parenteral suspensions of «Hydrocortisoni Acetas + Lidocaine Hydrochloride» and «Betamethasone» is conducted. We developed two technological methods for obtaining these medicinal preparations which are characterized by identical final quality. They correspond the requirements of the State pharmacopoeia of Ukraine and the European regulatory requirements concerning the choice of a method of bacterial purification of the readymade dosage forms.

Overweight precedes obesity initiation which is considered as a complex of hormonal and metabolic disturbances including cardiorespiratory system disturbances, diabetes mellitus 2 type, osteoarthritis, etc. The aim of our research was the study of morphofunctional and psychoemotional features of the girls with different massheight ratio and motor activity level when excluding the refined carbohydrates from food ration. Three groups were under the study: girls without overweight (control group), girls with overweight, and sportsgirls with normal body weight. A positive dynamics of studied indices was noted in all the groups. The control group was characterized by the changes of morphological (the decrease of total fat rate and chest circumference) and functional indices (the decrease of heart beat rate, tension index) and the improvement of psychoemotional state. In students with overweight both the most marked decrease of morphological indices (body weight, fat rate, body circumferences) and functional state improvement were revealed in comparison with other groups. In sportsgirls group both the reliable hip circumference decrease and the tendency to the decrease of other morphological indices and also the essential vegetative status improvement were observed. The most marked changes were observed in complex diet impact excluding the refined carbohydrates and physical exertions. The exclusion of the refined carbohydrates from the food ration can be used for overweight correction, the improvement of cardiovascular system state and psychoemotional indices.