The article analyzes the results of a survey of 55 pregnant women aged 20–40 years with a gestation period of 22–24 weeks (15 women — with a diagnosis of endocrine and uterine infertility; 20 — with complications of pregnancy; 20 — with a normal pregnancy). It was found that the occurrence of endocrine forms of infertility is primarily associated with adverse environmental conditions, especially in combination with obesity, hypodynamia, smoking and insuffi cient consumption of fruits and vegetables. The development of pregnancy disorders is largely associated with external factors (excessive use of products containing antioxidants; a small amount of vegetables and fruits in the diet; refusal of special nutrition for pregnant women, insuffi cient vitamin and mineral support during the pregravid period; adverse environmental conditions; smoking; hypodynamia and obesity). Thus, starting from the early stages of pregnancy, the doctor should assess the nutritional behavior and make recommendations for its correction.   

The article presents the peculiarities of forensic examinations with the identifi cation of characteristic features and problem sides in assessing the achieved outcomes of the dental rehabilitation of patients who used dental implants in their treatment. We analysed 135 civil cases related to defects in the provision of implant care for the period 2013–2016, containing the conclusions of experts from independent and state forensic medical institutions, statements of the claim of citizens and court decisions. The analysis showed the existence of certain differences in the methods of conducting such examinations, which is due to the properties of the dental implantation method it self characterized by a long period of treatment, the technical and methodological complexity of treatment, the fi nancial capacity of the method, and the participation of a large number of specialists in the treatment process. The perspective planning of the development of new criteria for the assessment of existing methods should be based on the ongoing situational analysis of emerging judicial practice in implant cases. This will allow to objectify the assessment of the achieved results of the treatment and to increase the evidence of peer review.

A prospective cohort study included 173 men 45–65 years with arterial hypertension (AH) and atrial fi brillation (AF). The 1st group consisted 53 patients with abdominal obesity (AO) and with diabetes mellitus of type 2; the 2nd group consisted 64 patients with AO without diabetes mellitus; the 3rd group was the comparison one it included 56 patients with AH and AF without accompanied pathology. The studied groups differed on age: average of patients of the 1st and 2nd group was reliably senior, than in patients of the comparison group. During the comparison of biochemical parameters it was found that patients of the 1st and 2nd group had a signifi cant increase in potassium, creatinine, urea compared of the comparison group higher. The fi brosis marker galectin-3 was higher in patients of the 1st group then in patients of the control group. In patients of the 1st and 2nd group there was a signifi cant decrease of the index of mass a myocardium of the left ventricular (IMMLV) compared to patients of the comparison group. The decrease of the IMMLV with concomitant comorbid pathology may be associated with metabolic processes that can slow compensatory muscular hypertrophy of the myocardium. Thus, patients with atrial fi brillation on the background of arterial hypertension, abdominal obesity and diabetes mellitus needed early diagnostics and correction of both AH and extracardial comorbid diseases in order to prevent early and rapidly progressive myocardial lesions.

In 74 patients with dorsopathies, the tolerability and effectiveness of shortened (up to 12–14 days) courses of health resort treatment were studied according to the results of the dynamics of clinical, functional, and laboratory statuses. It was revealed that the short-course treatment of patients with dorsopathies is accompanied by the development of unfavorable subclinical (in 21 % of cases) and clinical (in 37 % of cases) responses to physiotherapy. Addition of the medical complex with the chemical (medicinal liquid extract of Rhaponticum carthamoides ) and physical (laser therapy) adaptogens reduce the frequency and severity of subclinical and clinically signifi cant reactions to health resort treatment by 2.0–2.6 times and increases the immediate and long-term outcomes of shortened courses of health resort treatment. Supplementing the health resort complex for dorsopathy patients with adaptogens makes it possible to improve the tolerability of treatment and at the same time to reduce its duration, while the effectiveness of treatment increases.

In this study, non-selectively substituted N,O-diethylaminoethylchitosan (DEAE-CS-I) with a high degree of substitution of 1.2 and selectively N-substituted diethylaminoethylchitosan (DEAE-CS-II) with a moderate degree of substitution of 0.57 were obtained. The diethylaminoethyl substituent causes increased antibacterial activity in vitro of the obtained polymers compared to the initial chitosan. The antibacterial activity of diethylaminoethyl derivatives increases with a rise of the degree of substitution. The highest antibacterial activity was detected for the DEAE-CS-I derivative. The toxicity of the derivatives obtained also increases with an growth in the degree of substitution and, for a highly substituted derivative, has a pronounced dependence on concentration. At concentrations close to the minimum inhibitory concentration, the toxicity of both derivatives is comparable to the toxicity of the starting chitosan. The derivatives obtained are of interest for further in vivo studies.

The analysis of structure of dermatosis among 5–17 year old children and adolescents having various degree of obesity are provided. In the study group, the excess body weight or obesity of the I degree was registered 2.2 times more often than obesity of the II and the III degrees. Striae (24.8 %), atopic dermatitis (23.0 %), acne (17.8 %), acanthosis nigricans (11.9 %), keratosis pilaris (10.7 %), warts and molluscum contagiosum (18.5 %) were diagnosed most often. In a number of patients more, than one disease of skin were diagnosed: in children and adolescents with excess body weight the quantity of cases of dermatological pathology exceeded group number by 1.2 times, with obesity of the I degree — by 1.4 times, with obesity of the II degree — by 1.5 times, of the III degree — twice.

The reporting forms No. 9 called “Information on the incidence of sexually transmitted infections and infectious skin diseases” of regional observation, approved by Russian Federal State Statistics Service were analyzed in order to study the modern features of the epidemiology of trichomycoses and foot mycoses in Novosibirsk during 2009–2018. There has been an increase in the primary incidence of mycoses of the feet and hands; trichophytoses and onychomycoses, as well as a decrease in this indicator among patients with microsporia in the reviewed period in Novosibirsk. The onychomycoses took the leading position in the structure of dermatomycoses, mycosis of the feet and hands was the second one, microsporia — the third one, trichophytosis — the last. The gender-age ratio of patients showed that women older 40 years suffered from onychomycoses more often, women older than 40 years had mycosis of the feet and hands, also female children aged from 0 to 14 years had microsporia, male children aged from 0 up to 14 years had trichophytosis.

Over the period of 2013–2018 113 patients with approved diagnosis of paranoid schizophrenia (suffering for more than fi ve years) associated with the cannabinoid use dependency syndrome who had taken up the cannabinoid use before the paranoid schizophrenia manifestation (mean age in the group was 32 ± 4) were chosen for the investigation during which the effect of cannabinoids on the course of paranoid schizophrenia was studied. The control group consisted of 113 patients with paranoid schizophrenia who did not use psychoactive drugs including cannabinoids (mean age in the group was 34 ± 2). It was revealed that the early cannabinoid use is the factor that signifi cantly increases the risk of paranoid schizophrenia development and aggravates its course that is proved by the earlier manifestation of the disease (at the age of 16 ± 4 in the main group versus 22 ± 3 in the control group), a rapid change of syndromes with the forming of negative symptomatology and the signifi cant decrease of a social activity level (the time of hospital stay was less than a year in the main group — 82 % of cases, in the control group — 13 % of cases).

The data on the clinical use in surgical treatment of patients with chronic osteomyelitis (CO) of plasty of postosteomyelitic cavity by biocompatible fi ne-grained porous titanium nickelide are presented. The study involved 90 patients aged 17 to 60 years (67 men and 23 women). 60 patients (observation group) after the implementation of sequestrectomy bone cavity fi lled with granules of titanium nickelide; 30 patients (comparison group) to fi ll the bone cavity after sequestrectomy used the traditional method — hemofi lling. It was found that the treatment of chronic osteomyelitis by sequestrectomy followed by plasty granules of titanium nickelide gives more positive results compared to the traditional method. The use of the new technology allows to reduce the number of postoperative complications and negative results in the long term, to reduce the period of inpatient treatment, to ensure the restoration of the bone defect in a shorter time, reduces the number of relapses of the disease and improves the quality of life of patients.

The aim of the study was to estimate course the peculiarities of chronic cystitis in women of different ages. The study included 334 women with chronic cystitis (CC). The patients were divided into 3 age groups: group 1 — 20 to 39 years old; group 2 — 40 to 59 years old; group 3 — elderly age (60 years old and older). Cystoscopy was performed, the frequency of cystitis exacerbations was estimated, a survey was carried out using the PUF Scale (Pelvic Pain and Urgency/Frequency Patient Symptom Scale) questionnaire, and urination diaries were evaluated. A higher severity of symptoms was revealed in patients with leukoplakia in all age groups. However, the incidence of leukoplakia signifi cantly decreased with age. In this regard, the observed age-related increase in clinical symptoms of CC is most likely associated with the emergence of age-related pathogenesis factors. An inverse correlation between the presence of leukoplakia and mucosal edema was detected in women with the same symptoms. The two-way analysis of variance revealed two factors associated with increasing severity of chronic cystitis symptoms: age and the presence of squamous metaplasia (leukoplakia). 

The literature review presents current data on acute gastroenteritis (AG) of viral etiology. The share of AG in the etiological structure of acute intestinal infections according to foreign and domestic authors varies from 25 to 60 %. The features of the most common pathogens of AG — NV, rotaviruses, astroviruses, their genetic diversity and variability are considered. The features of epidemiology, clinics, modern methods of laboratory diagnostics and approaches in the treatment of AG of viral etiology are refl ected.

The article is devoted to the 100th birth anniversary of a prominent Russian internist, the creator of the original Siberian Scientifi c School of Internists, Corresponding Member of the USSR Academy of Medical Sciences and founder of the Internal Medicine Сlinic of the Novosibirsk Regional Clinical Hospital (1955–1977), Honorary Professor of the Novosibirsk State Medical University (NSMU) Aristarkh A. Demin (1918–1977). Brief biographical information on the scientist included the period of the Great Patriotic War (1941–1945). Ar.A. Demin headed the Internal Medicine Department of the NSMI (now — NSMU) in 1953–1977. He is known for his studies of post-war septic endocarditis (SE), and co-author of the multivolume “Internal Medicine Guidelines.” Ar.A. Demin advocated the possibility of SE development on unchanged heart valves, and not only on the rheumatic fever background as was thought (Moscow, 1962). For the fi rst time in Russia, Ar.A. Demin described multiple congenital arterio-venous aneurysms of the extremities, recognized a complete congenital heart block in Roger’s disease and for the fi rst time in Siberia, he diagnosed and described systemic lupus erythematosus. The principles of SE treating designed by Ar.A. Demin are refl ected in 60 doctoral and candidate dissertations of his followers. The original Internal Medicine Scientifi c School that he created at NSMU is now successfully solving current problems of theoretical and practical medicine. The scientifi c students and followers of Ar.A. Demin are now the famous scientists, Heads (in the past and now) of NSMU Departments, Professors — L.D. Sidorova, V.A. Kolayev, M.I. Loseva, V.A. Galenok, Al.A. Demin, T.I. Pospelova, N.L. Tov and L.A. Shpagina.