No 5 (2015)
13.00.00 ПЕДАГОГИЧЕСКИЕ НАУКИ
1 168
Abstract
The importance of formation of administrative competences at principals of medical organizations in the modern conditions of development of health care sector is presented in the article. Results of studying of productivity of principals’ professional development program of the medical organizations of Siberian Federal District are stated. The obtained data staticize the necessity of improvement of the contents, forms and methods of principals’ training.
J. E. Turchina,
O. Y. Sharova,
V. G. Ivanov,
N. P. Vakhrusheva,
O. P. Fatyanova,
T. K. Turchina,
N. M. Potylitsyna,
S. L. Nefedova,
V. G. Bitkovskaya,
A. A. Cheremisina,
E. P. Danilina
2 109
Abstract
In the presented article New approaches in the assessment of practical abilities of junior students of university are considered during passing total examinations after summer work practice.
O. A. Kornilova,
V. V. Ignatova,
N. V. Tikhonova,
E. A. Dobretsova,
K. M. Korotkova,
J. E. Turchina,
E. A. Prikhodko
3 110
Abstract
An experience of formation of professional reflection of future bachelor of social work is described in the article due to creation of organizational and heuristic condition which main implementer are socioreflexive situations. Criteria and-level characteristics of level assessment of professional reflection formation are presented. Methods of heuristic training are offered to use in student teaching: exercises, reflections, empathy and projections; receptions: critical analysis, comparison, interpreting, problematization, presentation and microdesign.
4 139
Abstract
The principles of creation of competence-based model of the university graduate - the specialist of «Human resource management» department are offered in the article on the basis of the analysis of educational and professional standards. Integrative approach to development of competence-based model of the graduate is justified.
5 95
Abstract
Results of the research among Management department students’ on their conceptualize of the administrative activity and their personal readiness for formation of administrative competences are presented inthe article. The necessity of introduction of the competence-based focused forms and methods of training in educational process upon transition to new educational standards is proved.
7 323
Abstract
The problem of research of emotional intelligence as important factor in the context of professionally significant qualities of the person is considered in the article. The results of researches of this phenomenon presented in literature in various applied directions and connected with sort by intellectual and behavioural skills are generalized (professional success, administrative activity, an adaptability and efficiency in communication). The results of research referred on detection of features of interpersonal and intrapersonal emotional intelligence at the students who are trained in medical and pedagogical higher education institutions are represented.
8 106
Abstract
Methodical approach to assessment of readiness of interns to pharmaceutical activity is considered in the article. The objective of research consisted in development and realization of methodical approach to determination of theoretical, personal and practical readiness of interns for pharmaceutical activity. During the research it was established that theoretical and practical training of interns has an optimum level and makes 6,8 and 8,4 points respectively, personal readiness of interns has an optimum level (GPA 8,1).
9 104
Abstract
Experience of development and application of qualimetrical approach with usage of expert evaluation for definition of degree of formation of competences of the «Pharmacognostic Analysis of the Medicinal Vegetable Raw Materials Containing Essential Oils and Bitterness» module of discipline of «pharmacognosy» is considered in the article. Possibility of usage of received results for objektivization of assessment of a level of competences development of student is demonstrated.
10 100
Abstract
The purpose of our research was the assessment of efficiency of usage of cloud technologies in educating medical students at emergence of acute medical states. 243 students who were divided into two groups were involved in the research: with traditional training and training with usage of information storage system «Mail.ru Cloud». The obtained data show that students from the second group cope with information search quicker, they increased motivation to obtainment of knowledge, inquisitiveness, aspiration to mastering professional knowledge and formation of professionally important qualities.
11 90
Abstract
The neccessity of usage of theoretical component for teaching physical education on occupations with students of the higher school is presented in the article. Addition of the information block to physical activity promotes increase of sensibleness of exercises performance by students. The analysis of literature, sociological poll and experience of the author of article was used for clarification of opportunities and range expansion in teaching.
12 153
Abstract
The analysis of the working program and educational and methodical complex in «Pediatrics» made by the staff of hthisiopulmonology chair was performed for the purpose to establish features of teaching Phthisiology discipline to students of pediatric faculty on FSES HPE. The assessment of the methods of training applied in department is presented. Transition in phthisiology teaching according to FSES HPE and change of maintenance of Phthisiology subject demands entering some additions into the formulation of competences, dictates the necessity of self-performed students’ work, arise the necessary of improvement of estimated system.
13 105
Abstract
Pedagogical interaction of educational objects and subjects is analysed in the presented research. Styles of pedagogical communication are presented. Aspects of pedagogical communication are revealed.
14 400
Abstract
The current problem of interactive training introduction to modern innovative conditions in practice of higher educational institutions is considered in the article. Concepts of interactive training, interactive technologies of training are considered; the characteristic of interactive training technologies, popular in the conditions of pedagogical innovations is described, advantages and disadvantages of interactive occupation are marked out.
15 127
Abstract
Research of the leading coping mechanisms at students, as factors of adaptation to education is conducted in the article. In the cognitive sphere at most of students adaptive coping mechanisms prevail by E. Heim technique. In the behavioural sphere the strain of rather not adaptive coping mechanisms becomes perceptible: «compensation» and «derivation». A dismaturity of the emotional sphere of students is shown by intensity of such coping mechanisms, as «abreaction», «aggression» and «suppression of emotions». The received results testify to existence of problems in adaptation of students to training in higher education institution.
16 122
Abstract
Problems of psychology and pedagogical training of students of institute of arts for teaching practice in educational institutions are considered in the article.
17 109
Abstract
The necessity of activization of educational activity for formation professional competences at students is proved in the article. Activization of educational activity of students is considered via creation of pedagogical conditions and process of training on the basis of integrative approach.
14.00.00 МЕДИЦИНСКИЕ НАУКИ (14.01.00 КЛИНИЧЕСКАЯ МЕДИЦИНА)
21 120
Abstract
The results of inspection and treatment of 72 patients are analysed in the article: endovascular recanalization of chronic occlusion of right coronary artery was carried out at 39 patients (the 1st group), entirely conservative therapy was received by 33 patients (the 2nd group). An assessment of quantity of segments with existence of perfusion defect and also an assessment of the clinical status of patients was carried out at investigation phases. The period of supervision was 12 months. Patients of the 1st group had authentically higher chances of decrease in FC of cardiac failure, the best indicators of 6-minute walking test and indicators of LQ, lower class of stenocardia of tension, and also decrease in number of points of perfusion defect less than 5 by data stress-MRI in comparison with control group (р < 0,001).
22 130
Abstract
The article is devoted to features of vegetative regulation of blood circulatory system at patients with pseudorheumatism (P). The objective of research: to study a vegetative regulation of blood circulatory system at patients with pseudorheumatism according to laser Doppler flowmetry. Materials and methods. Research included 2 groups of patients: patients with with pseudorheumatism (n = 75) and control group (n = 85). All surveyed ones were females, middle aged in two groups didn’t differ. Regional microcirculation of hand and vegetative regulation of blood circulatory system were estimated by means of laser Doppler flowmetry on «LAKK-2» device applied on palm skin of the IV finger. The received results . The patients with pseudorheumatism have statistically significant vegetative disturbances regulation of cardiovascular system comparing with control group. Area of their application . Out-patient and stationary stages of maintaining of patients with pseudorheumatism. Conclusions . Patients with pseudorheumatism according to laser Doppler flowmetry have statistically significant disregulation of circulation activity comparing with control group.
23 147
Abstract
Results of clinical application ofcombination of immunomodulators Licopid and Imunofan in treatment of patients with acute dontogenous osteomyelitis complicated with phlegmon of maxillofacial area are presented in the article. Research was conducted on the basis of maxillofacial hospital of SAHE CRCH during the period from 2012 to 2015 with participation of 214 patients hospitalized in the emergency order. The analysis of basic clinical and anamnestic data, features of disease progress and outcome of acute dontogenous pyoinflammatory process in groups of patients with various tactics of medicamental therapy is carried out. By results of the performed work it is established that adding immunomodulatory component to the basic scheme of treatment of patients with acute dontogenous osteomyelitis of gnathic bones is an effective remedy of prophylaxis of making the process chronic.
24 355
Abstract
The main data on growth promoting factor of endothelium of vessels are presented in the literature review (vascular endothelial growth factor, VEGF) and spheres of its clinical application. Physiological and pathological methods of vessels formation and factors of angiogenesis regulation are considered in the article. The main VEGF properties and its receptors, their role in regulation of vascular growth in norm are described and at development of malignant neoplasms and retina diseases. Data on the preparations inhibiting the VEGF-mediated angiogenesis are generalized. Some directions of further development of anti-angiogenic therapy are specified.
25 91
Abstract
A set of teenagers and their families’ problems in the form of disturbances of physical development, deviations in functioning of organs and systems, accentuation of personal features of character, especially from families of groups of social risk are revealed by method of a complex assessment of health state with profound studying of psychological characteristics for studying the influence of microsocial conditions on a state of health of 16-17-year-old teenagers for the purpose of optimization their medico-psycological-social maintenance in out-patient conditions.
26 181
Abstract
Addictive ideation and syndrome of frustration as basic links of addictive range of disturbances within formation of basic provisions of psychodynamic spectral psychiatry authors allocate. Formation of psychological addiction and further development of addictive process to possible including of physical addictions takes place on basis of preaddictive components. Explicit and implicit forms of frustration syndrome are allocated. Value of inadequate parent education in formation of addictive range is emphasized.
27 527
Abstract
The system of quantitative assessment of pelvic prolapse (POP-Q) represents objective method of assessment of state of patients before expeditious correction of pelvic prolapse. Possibilities of this method are shown on the example of big selection of such patients and long terms of postoperative observation. Simplicity of performance, low cost and the uniform principles of usage allow to recommend POP-Q system as the standardized approach to assessment of state of patients with pelvic prolapse.
28 253
Abstract
Sling operations with usage of synthetic loop are among the main methods of expeditious treatment of stressful urinary incontience at women. On the basis of large selection of patients and long terms of postoperative observation their efficiency regardless of sling operation is proved in the research. One of important criteria of treatment is the state of life quality. Significant improvement of life quality after sling operations was presented by means of special questionnaires. Simplicity of usage, low cost and high informational content of the specified questionnaires form the basis for their reference to broad clinical application.
29 106
Abstract
Efficiency of primary plasty of genitourinary fistulas at 226 women in the conditions of clinic with a wide experience of application of such operations made 91,6 %. Efficiency of primary correction of fistula is authentically influenced by the following factors: extent of fistulous defect, extent of cicatrical changes in area of fistulous course and existence of the previous operations on fistula plasty. The obtained data can be used for the purpose of optimization of approaches to treatment of this category of patients.
30 167
Abstract
Reticular grafts are used for correction of pelvic prolapse of the II-IV stages at 376 women: Prolift system in 286 (76,1 %) cases and «Prolift+M» - in 90 (23,9 %). Life quality of patients was estimated by means of PFDI-20 and PFIQ-7 questionnaires. Terms of postoperative observation of patients made 6-110 months (a median - 52 months). According to both questionnaires life quality authentically improved to the extremity of the 1st month after operation, then its further improvement by 6th month is registered. After 6 months indicators of life quality steadily remained at this level without deterioration throughout the entire period of observation.
31 143
Abstract
Research objective : to study prevalence of genetic markers the prothrombotic of changes at children on the basis of the center of health. Materials and methods . Genetic research the prothrombotic of polymorphic markers of candidate genes at 208 children from 3 groups. Results . In the 1st group there were less than three signs of the burdened thrombogenic anamnesis, in the 2nd - existence of three and more signs at each child, in the 3rd group - a combination of an irrational delivery, an inactive way of life and vegetovascular dystonia. Conclusion. Formation of groups of risk at children - a form of preventive actions of severe complications and consequences of clottage-associated diseases at adults.
32 123
Abstract
The analysis of immediate results of treatment of patients with gastroesophageal reflux disease of the IV degree complicated with Barrett’s esophagus by method endoscopic argon-plasma coagulation is presented in the article. The characteristic of complications both in the early postoperative period, and in late is contributed, preferable tactics of supervision, treatment and maintaining of this category of patients is offered. The influence of argon - plasma coagulation on mucous and terms of the subsequent surgery - fundoplication is analyzed in the article.
33 121
Abstract
Research objective . Due to the orientation of domestic medicine that was recently defined on creation of accurately stipulated algorithms and references on treatment of the majority of the main nosological forms it is added up to create the review of most actual and modern information on current trends of diagnostics and treatment of achalasia of cardia. The review of foreign articles and references performed.
34 128
Abstract
Complex research of processes of the peroxidation of lipids (POL), system of antiperoxide protection, purine and power exchange at 120 children of early age from Omsk with anemia of chest is conducted. It is established that hypocromic anemia at children of early age of the large industrial center is heterogeneous due to existence of forms with classical (at iron deficiency anemia) and atypical ratio of ferrokinetic indicators (at decrease in serumal iron lack of natural increase in the general iron-binding ability of serum). The violations of purine exchange leading to intensification of POL processes in membrane structures and activation of antioxidant system of blood with a glutathione metabolism intensification, leading to strengthening of degradation of erythrocytes are revealed.
35 109
Abstract
The results received by authors on the basis of the comparative analysis of indicator of speed of glomerular filtration at 3155 children with chronic renal disease allow to approach differentially to a formula choice for calculation of this indicator depending on age. It is recommended to use a method of calculation of speed of glomerular filtration for the Schwartz formula presented in the National guide to pediatrics (2009) as the most correctly defining method of the stage of chronic renal disease, except for cases when calculation of this indicator is performed to children in age group till two years. In such situation it is advisable to make calculation of speed of glomerular filtration for the Schwartz formula recommended by V. V. Dlin (2005).
A. A. Komarova,
Y. Y. Kitayeva,
I. V. Antonova,
G. A. Kovaleva,
S. I. Artyukova,
E. V. Konoferchuk,
L. I. Genyk,
O. V. Antonov
36 153
Abstract
Research objective was studying of epidemiological manifestations of congenital anomalies of development of kidneys in children and fetuses in Omsk. The mean annual indicator of frequency of development of abnormalities of urinary organs at children from 0 to 1st month of life and fetuses in Omsk for 10 years made 2,26 ‰. With the greatest frequency the congenital renal dysplasia, agenesia and hydronephrotic transformation of a kidney were registered in structure of urinary abnormalities at fetuses. Congenital renal dysplasia, hydronephrosis and congenital pyeloectasia were in the lead at deadborn children. Among all anomalies of uric system from 0 to 1st month of life congenital pyeloectasia and hydronephrosis were mainly diagnosed at the children who were born live. In structure of the chronic diseases of urinary system revealed in general from 0 to 17 years of life, the leading positions were taken by vesicoureteric reflux.
37 164
Abstract
Curation of children with pyelonephritis against pyeloectasia remaining during the 1styear of life demanded studying of the reasons and states of emergence and preservation of the sizes of dilatation of pyelocaliceal system of kidneys and, as a result, developing of pyelonephritis at early age. In the work results of clinical inspection of 148 families including ones with children with pyelonephritis against congenital resistant pyeloectasia - 73 children (the main group) for 3 years are generalized. During the 1styear of life at 94,7 % of children of the main group the sizes of renal pelvis didn’t decrease and averaged 8,5 mm that practically corresponded to number of the children who were allocating an anti-gene of cytomegalovirus (90,8 %) in the neonatal period and who had various clinical manifestations of infectious process. It is possible to assume that existence of infectious process promoted preservation of the expanded sizes of pelvis, and to consider pyeloectasia at such children as secondary anomaly of development against pre-natal cytomegalovirus infection.
38 108
Abstract
Treatment options of patients with sterile acute pancreatitis are discussed, role of computer tomography in diagnostics and choice of treatment options is estimated in the article. Data of clinical supervision are provided. Existence of gas vials in the field of infiltratae and pleurisy on the tomogram, the age older than 60 years, earlier performed surgery states to high risk of infection. The necessity of conservative approach to treatment in the absence of the specified signs is proved.
39 157
Abstract
Research objective: to establish features of clinical manifestations and the vegetative status at children with enuresis and neuromuscular dysfunction of bladder against displasia of connecting tissue. Research included 26 children. Enuresis was diagnosed at 65,3 % of patients, and at 34,6 % - neuromuscular dysfunction of bladder. As a result of research signs of displasia of connecting tissue are revealed at 100 % of patients. Displasia I of degree is revealed in 65,3 % of cases, II - in 34,7 %. Signs of displasia of high degree are revealed in none of cases. Clinical symptoms of vegetative dysfunction are revealed more often in group of patients with the II degree of expressiveness of displasia syndrome.
40 186
Abstract
Features of the extremely high-frequency (EHF) therapy as way of improvement of life quality at patients with alimentary obesity are considered in the article. For the purpose of studying of EHF-puncture influence on life quality, psychological and anthropometrical indicators of patients with alimentary obesity within 12 weeks research of 56 people was conducted. Patients were divided into 2 groups: the first received a basic complex - a hypohigh-calorie diet and physiotherapy exercises, the second - the basic complex added with the EHF-therapy course. During research statistically reliable distinctions of indicators of life quality, psycho- and anthropometries between groups of supervision testifying to efficiency of EHF-puncture application at patients with alimentary obesity are received.
41 115
Abstract
Data of the stomatologic status at children with gastroduodenal pathology, and also dependence of results of research on character of a course of a disease are stated in the article. Authors emphasize on the necessity of complex research and treatment of patients with the combined pathology of organs of an oral cavity and underlying regions of digestive tract.
42 122
Abstract
In article Data on sealing of teeth fissures at children - one of the leading methods of prevention of caries are stated in the article. Big clinical material allowed to prove that during 2,5 years sealant completely remained more than in 98 % of teeth. Fissure caries developed only in 2 % of teeth. It proves high efficiency of a method of prevention of caries - sealing of teeth fissures.
A. O. Izyumov,
E. V. Noskova,
M. V. Kolybelkin,
E. Y. Apraksina,
T. V. Borodina,
I. V. Klimova,
K. S. Shchelkunov
43 137
Abstract
Relevance of article is based on prevalence of inflammatory processes at children of various age groups and nosology. Considering the increasing value of local and general complications of inflammatory processes of maxillofacial area at children of Novosibirsk and the Novosibirsk region, the analysis of work of a hospital over the last 5 years was performed. Therefore it was revealed that negotiability for the stationary care at children with diseases of maxillofacial area is considerable part among the general stream of patients.
14.00.00 МЕДИЦИНСКИЕ НАУКИ (14.02.00 ПРОФИЛАКТИЧЕСКАЯ МЕДИЦИНА)
N. V. Tikhonova,
S. N. Derevtsova,
A. A. Romanenko,
N. N. Medvedeva,
E. A. Dobretsova,
A. V. Zharova,
S. L. Baksheeva,
N. G. Astanina
53 98
Abstract
Results of anthropometric and bioimpedancemetric checkup of women of advanced age are presented in the article. 169 women took part in inspection, average age of the surveyed was 68,2 ± 0,4 years. By results of anthropometric measurements new approaches to aftertreatment of patients of advanced age were created.
54 118
Abstract
The structural and organizational model of electron account of the healthy child is presented in the article. The access algorithm to electron account of the healthy child and the main sections in the most actual directions are presented.
55 109
Abstract
A sociological research was conducted for the purpose of studying of urologists’ opinion concerning the patients with urolithic illness recieving treatment at the out-patient level. As a result of the poll the data characterizing the questions recieving from patients during treatment, possibility of their decision at remote consultation, tactics and methods of improvement of assistance at patients with urolithic illness at the out-patient level are obtained.
56 122
Abstract
The demand and attendance of electron account of the healthy child is analysed in the article, the level of users gain is revealed, attendance of various sections of resource and satisfaction of parents of children of early age with electron account of the healthy child is estimated.
14.00.00 МЕДИЦИНСКИЕ НАУКИ (14.03.00 МЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ)
6 114
Abstract
Morphometric research of striated excretory ducts of parotid and sublingual sialadens at teenage males of rats who were exposed to chronic intoxication with lead and cadmium was conducted. The morphometry showed that entering of high-density metal metals causes expansion of lumen of striated excretory ducts, and also depression of increase of epitheliocytes lift of a wall of ducts. The area of interstitial space round a wall of ducts at accumulation of cadmium decreases, there is a growth of connecting tissue at introduction of lead in this area. Changes are more expressed in ducts of parotid sialaden than in sublingual sialaden.
44 92
Abstract
The objective of research : studying of interorgan relationship between marrow and appendix at autotransplantation. Research methods . Autotransplantation at mice by intravenous administration of the suspension of marrow received from the same mouse was performed. Further made Luminescent and histochemical research was conducted later. Results of research .The increase in number of granular luminescing cells with reduction of quantity of granules in them and reduction of number of corpulent cells owing to their destruction is registered at trial mice. Blast forms of cells increase in myelogram. The increase of neuroamines is also registered in appendix. Correlation relationship in marrow and appendix are distinguished. Conclusions : 1) new centers of multiplication come into sight; 2) strengthened interorgan correlation relationship between marrow and appendix are revealed.
45 133
Abstract
The objective of research : studying of influence of marrow allotransplantation on distribution of biogenous amines between bioaminocontaining structures of marrow and appendix. Research methods . Mice were intravenously entered the marrow suspension received from a mouse of other line (allotransplantation). Marrow and appendix were exhausted. Luminescent and histochemical research was made after that. Results of research . Allotransplantation up to 40 min is followed by activation of cells regulators, after there is a suppression of neuroamines synthesis, granular luminescing and corpulent cells gradually cease to synthesize neuroamines. In appendix, on the contrary, synthesis of biogenous amines in cells regulators was observed that was followed by increase in their contents in granular and corpulent cells. There is a correlation dependence between marrow and appendix. Conclusions : neuroamine regulation in marrow and appendix by means of the granular luminescing and corpulent cells with increase in number of cells regulators, and in them - neuroamines is revealed.
46 127
Abstract
Regulation of baroreceptive reflex is carried out due to the multilevel and multiple parameter interaction between departments of the vegetative nervous system (VNS) having oscillatory character and being in a condition of steady nonequilibrium on which all regulatory contours and processes having nonlinear character are realized. Range of the oscillatory processes connected with nature of interaction between departments of VNS and points of phase transitions is realized in a specific existential continuum which finally defines a cooperative reactivity of systems of baroreceptive reflex regulation.
47 201
Abstract
Morphometric research of striated excretory ducts of parotid and sublingual sialadens at teenage males of rats who were exposed to chronic intoxication with lead and cadmium was conducted. The morphometry showed that entering of high-density metal metals causes expansion of lumen of striated excretory ducts, and also depression of increase of epitheliocytes lift of a wall of ducts. The area of interstitial space round a wall of ducts at accumulation of cadmium decreases, there is a growth of connecting tissue at introduction of lead in this area. Changes are more expressed in ducts of parotid sialaden than in sublingual sialaden.
48 256
Abstract
The pharmacokinetics of new formulization Cineton on the basis of active ingredient 33,3’-diindolylmethane (DIM) containing pluronic is studied, 5 patients with hyperplasia have endometrium without atypia. DIM concentration in blood plasma was determined by method of a highly effective liquid chromatography with UF-detecting after single oral administration of preparation in a dose of 300 mg of DIM. The average AUC size made 343,9 ± 112,9 ng h/ml, average maximum concentration (Cmax) of DIM in blood plasma - 121,5 ± 38,7 ng/ml, average time of achievement of Cmax - 2,2 ± 0,45 h. It is established that the DIM substance is defined in blood plasma of patients during 10 hours after single introduction of preparation, calculated average time of deduction of preparation in systemic blood flow (MRT0inf) made 4,4 ± 1,35 h. The period of semi-removal (T1/2) made 1,9 ± 1,6 h. The received results confirmed high bioavailability of Cineton preparation.
49 281
Abstract
The sensorimotor profile, functional interhemispheric asymmetry and the level of emotional intelligence measured by means of Russian-speaking option of «Questionnaire of emotional intelligence» of K. Barchard and by means of the «Diagnostics of Emotional Intelligence» test of N. Hall were investigated. The analysis of the received results indicates various level of formation of emotional intelligence at men and women, communication of components of emotional intelligence with right and left hemispheres at persons with dextrocerebral asymmetry and at ambidexterity.
N. N. Ilyinskikh,
N. T. Yasakova,
E. N. Ilyinskikh,
I. N. Ilyinskikh,
A. E. Yankovskaya,
S. A. Saushkin
50 91
Abstract
878 men working at oil fields of the North of Siberia in the Tyumen and Tomsk areas are examined. 475 of them are the oil workers occupied in the sphere of direct oil production, and 403 - the administrative personnel of oil fields (control). Polymorphism on genes of biotransofrmation of xenobiotics in CYP1A1 and GSTM1 depending on length of service on oil fields of the North of Siberia is studied. In selection of the oil workers who worked 10-15 years on oil fields of Siberia practically there are no homozygous carriers of mutant alleles of these genes. Opisthorchiosis invasion caused in carriers of mutant homozygous options of genes acute increase of erythrocytes with microkernels. Clinical consequences of Opisthorchiosis invasion proceed much more seriously in the presence of Val/Val genotype-/-. Smoking strengthened mutagen effect of Opisthorchiosis invasion in all observed cases. The presented researh is performed with financial support of grants of RSNF N 15-06-10190 and 13-06-00709.
51 149
Abstract
The objective of research was the assessment of safety and acceptability of therapy by «Cineton» preparation on the basis of diindolylmethane (DIM) at patients with the diagnosis of hyperplasia of endometrium without atypia. Participants of research (81 patients) were randomized into 3 groups. Patients of the 1st group received the studied preparation in a dose of 400 mg of DIM per day. Patients of the 2nd group received the studied preparation in a dose of 600 mg of DIM per day. Patients of the 3rdgroup received placebo. The patients received standard hormonal therapy within 160 days in addition to taking of the studied preparation and placebo. The assessment of safety and acceptability of therapy was carried out according to results of registration of the undesirable phenomena (UP) clinically and by means of tool and laboratory methods of research. Totally during research 16 UP (19,8 %) were registered generally from reproductive system, 7 UP were connected with the termination of taking of preparation (1 - in group of «Cineton» taking of 400 mg of DIM per day, 3 - in group of «Cineton» taking of 600 mg of DIM per day, 1 - in group of placebo). Differences between groups on the UP frequency and cases of intolerance when comparing with placebo group weren’t statistically significant at application of both doses.
52 136
Abstract
Possibility of modification of eluting-system by means of radiation of stent with medicinal coating with stream of accelerated electrons for the purpose of prolonged release of anti-proliferative medicine from all mass of copolymeric matrix is investigated in the presented research. It is shown that it is possible to improve kinetic parameters of extraction of anti-proliferative medicine from coronary stent by means of technology of electron-beam modification. Profiles of chromatograms testify to chemical integrity of rapamicine and safety of stent.
14.00.00 МЕДИЦИНСКИЕ НАУКИ (14.04.00 ФАРМАЦЕВТИЧЕСКИЕ НАУКИ)
18 686
Abstract
Distinctions between the pharmaceutical organizations, realized different portfolios of business units are revealed in the work on the basis of questioning of experts. The time spent on the pharmaceutical market, quantity of assortment positions, structure of the realized goods and services, factors of competitiveness, strategy of development, action for competitiveness increase were studied. On the basis of the obtained data recommendations for two groups of the pharmaceutical organizations - issueing medicines on a free or preferential basis and the ones that are not issueimg are created.
19 205
Abstract
Classical and new approaches to promotion of medicines in Russia and rules of its management are investigated in the article. It is shown that the competition between the pharmaceutical organizations, domination in volume of consumption of import medicines that led to the growth medicines prices in Russia are increasing. As a result of it there is a necessary to strengthen classical approaches to promotion of medicines.
20 154
Abstract
The content analysis of the normative legal acts and scientific publications characterizing a condition of researches in the field of placement of the pharmaceutical organizations is carried out at the regional level. Characteristics of distribution of the Voronezh pharmaceutical organizations in general and on certain districts are investigated, their regional features are revealed. On the basis of the received results potential places for opening the new pharmaceutical organizations in Voronezh are offered.
ISSN 2542-1174 (Print)
