The effect of the course of superweak infrared radiation modulated at 125 Hz frequency on the concentration of pro- and anti-inflammatory cytokines (IFNγ, IL-4 and IL-10) was studied in the blood of 36 children and adolescents with tuberculosis of the intrathoracic lymph nodes. It was found that IFNγ concentration increased by 18.9 % and in patients without infrared therapy by 9.6 %. This indicates immunostimulatory properties of infrared radiation. Positive changes in the cytokine profile were found in 22 % of children who had received this kind of physiotherapy and only in 16 % of cases in the group without infrared treatment.

Chronic prostatitis (CP) is a common condition that predispose to recurrence and development of complications. The 100 patients with CP participated in the research devoted to assessment of opportunities of the extracorporeal shock wave therapy (ESWT). 73 of them have had CP complicated with prostatic calculi. All patients have had ESWT complex treatment on the “Dornier Aries ”. The results of treatment were estimated on a scale of CP symptoms called NIH - CPSI (National Institutes of Health - Chronic Prostatitis Symptom Index) and on prostatolithiasis level. Course patients with CP had insignificant positive dynamics immediately after ESWT: the number of points on a scale of symptoms totally decreased from 20.5 to 18.0, however the mean points decreased on average up to 9.8 in a month. The secretion of prostate was debrided in 67.9 % of CP patients with complicated prostatolithiasis in 3 months after ESWT combined with phytotherapy by drug canephron n; the amount of pain has decreased for 86.7 %, urination disturbance level - for 65.2 %, prostatolithiasis level - for 60.9 %. ESWT peformed on “Dornier Aries ” is highly effective in patients with CP of IIIа, b category and in prostatolithiasis.

The objective of the study is the investigating of incidence and effect of clinical peculiarities and the type of immune suppression therapy on the onset of diabetes mellitus in recipients of kidney transplant (RKT) being followed up in Novosibirsk Regional Nephrology Center. Posttransplantation diabetes mellitus (PTDM) according to KDIGO guidelines was diagnosed in 8 % of cases (17 patients: 10 males and 7 females at mean age of 49.4 ± 12.4) of 226 RKT. All the patients were given calcinuerin inhibitors (cyclosporine A - 9 patients and tacrolimus - 8 patients). The clinical peculiarities of patients’ group with PTDM are the prevalence of individuals above 40 having obtained a transplant from a deceased donor, and in most of cases having nutritive status disturbances to the extent of obesity. The correlation between the rise of body mass index and female sex claims extra attention to the monitoring of carbohydrate metabolism in this group of RKT. The prevalence of application rate of tacrolimus in patients with PTDM was not revealed. The integrated assessment of risk factors in the onset of diabetes mellitus in RKT is necessary.

The informativeness of existing diagnostic markers of sepsis at various stages of its development remains controversial. The aim of the study was to assess the diagnostic significance of peripheral blood cell composition, some biochemical tests, as well as modern sepsis markers. 54 patients aged 20 to 70 years with verified abdominal sepsis participated in the study. The results obtained indicate a low diagnostic value of such indicators as leukocytosis and the appearance of immature forms of leukocytes. The lymphocytic index is the most informative (100 %) diagnostic criterion for sepsis at all stages of observation regardless of severity, timing and presence hemodynamic disorders. The diagnostic value of acute phase proteins of procalcitonin and C-reactive protein upon admission to the hospital was 64 % and 82 % respectively. The high concentration of IL1-Ra (1000-6000 pg/ml) can be regarded as a predictor of mortality.

For the purpose of studying of parameters of a functional state of an vascular endothelium in persons with the family anamnesis burdened on the arterial hypertension for definition of tactics of further observation and treatment it was conducted the research of 95 young people (58 women and 37 men) from 17 up to 28 years old (middle age 23.9 ± 2.7) with the hereditary burden on the arterial hypertension. The control group was formed 24 people from 18 up to 28 years old without cardiovascular pathology, serious chronic diseases and the arterial unfortunate anamnesis on the arterial hypertension. Depending on the blood pressure level patients have been divided into 3 groups: group 1 - patients with the arterial hypertension; group 2 - patients with high normal blood pressure; group 3 - persons with the normal blood pressure level. They conducted ultrasound investigation of a brachial artery, of the common carotid artery. They estimated an endothelium-depended vasodilation during the test with reactive hyperemia. They counted indicators of rigidity of a vascular wall, pulse wave velocity. In groups 1st and 2nd an endotelium-depended vasodilation was lower on the average 1.3 times in comparison with control. The greatest average index of the thickness of intima - media complex of the common carotid artery was observed in persons from group 1, by 12.5 % reliably exceeding a similar indicator in group 3 and in control group. Therefore, in persons with the hereditary burden on the arterial hypertension the thickness of intima - media complex of the common carotid artery was increased according to increase of the blood pressure level. Average indexes of coefficient of cross extensibility of a wall of an artery in groups 1-3 were reliably less also by 40, 30 and 17.8 % respectively in comparison with control. It was revealed the reliable increase in pulse wave velocity through the vessels of elastic type in 1st and 2nd groups exceeding by 22 and 18 % index of a similar indicator in control group, respectively. Thus, the patients with the hereditary burden on the arterial hypertension have the dysfunction an endothelium of vessels, as evidensed by disorder of the vasomotor reaction of the brachial artery, the increase of thickness of intima - media complex of the common carotid artery, the decrease in its elastic properties and the increase in a rigidity of a vascular wall.

The purpose of the study was to evaluate the dynamics and characteristics of abdominal pain syndrome in patients with cholelithiasis (CL) during a 10-year follow-up period. The work is a fragment of a long-term prospective observation of patients with CL. Patients who participated in the study were divided into 2 groups: the 1st group ( n = 113) of those who had undergone cholecystectomy (CE); 2nd group (comparisons) ( n = 92) included receiving conservative treatment patients who had been diagnosed with CL 10 years before. Patients of both groups were divided according to the initial variant of the CL course: symptomatic and asymptomatic. It was found that in CL patients after CE, the incidence of a biliary pain decreased by 25.7 % ( p < 0.001). In the group with initial symptomatic course cholelithiasis after CE, there was a statistically significant reduction in the biliary pain by 31.1 % compared with patients treated with conservative therapy ( p < 0.001). The incidence of biliary pain increased by 11.9 % ( p < 0.001) in the conservative therapy group, including CL patients with an initially asymptomatic course. The incidence of dyspepsia syndrome increased by 33.9 % ( p = 0.039) in patients after CE, an especially significant reduction was in the initially asymptomatic CL patients.

There are the data in the research devoted to studying of structural features of cell populations of a liver and a gastric mucosa at patients with markers of HCV- and HBV- of an infection. It was performed the clinical morphological research of 95 patients with markers of HCV- and a HBV-infection (52 men and 43 women aged from 16 to 66) and with gastric dysfunction and 41 patient with the chronic gastritis associated with Helicobacter (H.) pylori (group of comparison consisted of 15 patients with the chronic gastritis which isn’t associated with H. pilori ). At all patients with HBV- and a HCV-infection the stomach mucosa is involved in pathological process, at the same time the fibrosing form of a lesion is a gastropathy prevails; it was not found out the essential correlation of structural changes with degree of a hepatitis activity and also with existence of H. pylori . The analysis of structural changes of a stomach at patients with the chronic gastritis associated with H. pylori showed what at a high degree of activity of H. pylori in a gastric mucosa the catarrhal fibrosing process prevails. In the absence of H. pylori fibrosing changes dominate.

15 male patients with chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA) (average age 68.4 ± 3.6 years) are examined for the purpose of studying the features of systolic and diastolic functions of the left ventricle regarding the state of ascending aorta in elderly people with arterial hypertension combined with COPD and BA. A comparison group consisted of 15 patients with COPD (average age 63.4 ± 3.2 years). All patients have COPD of B category. It was revealed that elderly people having combined COPD and BA with arterial hypertension, unlike patients COPD, show higher expression of concentric hypertrophy of the left ventricle when rising its contractility, in particular, global longitudinal systolic performance against the lack of differences on its diastolic function and, in particular, longitudinal.

Described clinical case shows that therapy of precancerous forms of lichen planus should be complex and include sanitation of the whole organism. In this regard, it is necessary to conduct a complex examination of patients of this profile in a specialized hospital to prevent diagnostic errors and to select individual, differentiated and rational therapy of organ pathology, which contributes to restoring the oral mucosa and improving the patients’ quality of life.