Introduction. Russia has a signifi cant elderly population, with 14.2% aged 65 years or older, however, little research has focused on this group. Russia has seen a rapid increase in low life expectancy, coupled with high alcohol consumption and its associated health eff ects. Alcohol is known to promote sleep disorders among the elderly, and its relationship with sleep disturbance is a signifi cant factor in assessing the quality of life of the elderly. However, the specifi c relationships between pure alcohol (PA) consumption and sleep among Russian community-dwelling older people remain unknown. A i m . To clarify factors related to sleep quality of older Russian people in the Far East, focusing on PA consumption.

Materials and methods . In this cross-sectional study, 348 Russian community-dwelling older people with their basic attributes, health status, self-reported drinking habits, Short-Form Health Survey-8 (SF-8), Geriatric Depression Scale, and Pittsburgh Sleep Quality Index (PSQI) were analyzed. The participants were divided into two groups (PSQI <6=0, ≥6=1) and compared using the t test, the χ2 test, and logistic regression analysis. Results. Sleep disorders in women were associated with longer daily nap time (odds ratio (OR) = 2.713; 95% confi dence interval (CI): 1.136–6.480) and sedative medicine intake (OR = 0.201; 95% CI: 0.070–0.576). In men, sleep disorders were associated with the physical component summary (PCS) (OR = 0.925; 95% CI: 0.891–0.960), longer daily nap time (OR = 2.260; 95% CI: 1.214–4.205), sedative medicine intake (OR = 0.327; 95% CI: 0.174–0.619), and PA intake (OR = 1.030; 95% CI:1.007–1.054).

Conclusion. Excessive PA consumption can be a factor for decreased sleep quality, daytime sleepiness, and decreased PCS score in men. In women, sedative medicine intake was associated with longer daily nap times, leading to decreased sleep quality. Accumulation of data on PA intake of the Russian elderly population and the recommendation of appropriate moderate consumption based on regional and physiological criteria are important topics for future studies.

Introduction. Propranolol is a non-selective β-adrenergic blocker used to treat cardiovascular and other medical conditions in both adults and children. In adults, it is employed for the treatment of arterial hypertension, angina pectoris, arrhythmias, and essential tremor; in children, it is used for treating arrhythmias, pheochromocytoma, thyrotoxicosis, migraine, infantile hemangiomas, as well as symptoms of anxiety and aggressive behavior.

Aim . To conduct an analysis of the range of propranolol drugs in the Russian and global pharmaceutical markets.

Materials and methods. The objects of the research were the state registers of medicines of the Russian Federation (RF), the Republic of Belarus, the Republic of Kazakhstan, the Republic of Armenia, and the Kyrgyz Republic, countries of the Eurasian Economic Union (EAEU), the United States, and the United Kingdom. Research methods: comparative, structural, statistical, logical, marketing, and content analyses.

Results . In the RF, 10 propranolol-based drugs are registered, 9 of which are in the form of tablets for adults in dosages of 10 and 40 mg, included in the List of Vital and Essential Drugs (LVED), and manufactured in the RF; 1 is an oral solution in a dosage of 3.75 mg/ml, intended for children, not included in the LVED, and produced in France. In the Republic of Belarus, 2 propranolol drugs as tablets for adults, in dosages of 10 and 40 mg are registered, manufactured in the Republic of Belarus and Ukraine. In the Republic of Kazakhstan, only a pediatric oral solution with a dosage of 3.75 mg/ml, produced in France, is registered currently. In the Republic of Armenia and the Kyrgyz Republic, only 1 trade name (TN) is registered – tablets for adults 40 mg manufactured in the Republic of Belarus. In the EAEU, 2 propranolol-based drugs are registered: tablets 10 and 40 mg (RF) and an oral solution 3.75 mg/ml (France). In the United Kingdom, 17 TN of propranolol are registered in various dosages and dosage forms (DFs): tablets, fi lm-coated tablets, and extended release capsules. Dosages of solid DFs include 10, 40, 80, 160 mg. Liquid DFs include oral solutions 5 mg/5 ml, 10 mg/5 ml, 40 mg/5 ml, and 50 mg/5 ml. In the United States, 18 TNs of propranolol available in various DFs are registered: tablets (10, 20, 40, 60, 80 mg), extended release capsules (60, 80, 120, 160 mg), oral solutions (3.75 mg/ml, 20 mg/5 ml, and 40 mg/5 ml), and injectable solutions (1 mg/ml).

Conclusion. In the RF, propranolol-based drugs are available in two DFs: tablets (10 and 40 mg) and an oral solution (3.75 mg/ml). A similar situation is observed in EAEU’s countries. In the markets of the USA and the United Kingdom, there is a wide range of propranolol-based drugs, including 7 solid DFs, 1 injectable DF, and 6 liquid DFs, including for children. In the RF, only one pediatric drug (in a single dosage) in the form of oral solution is registered. This drug is imported and is not included in the LVED, which contributes to its high cost and, consequently, low accessibility for the population. The issue of the lack of aff ordable and diverse pediatric propranolol DFs in the RF requires urgent resolution.

Introduction. Issues of adolescent girls’ health in modern society are becoming increasingly relevant requiring close attention and scientifi c research.

Aim . To assess the reproductive and somatic health of adolescent girls in Novosibirsk and the Novosibirsk region (NR), as well as to analyze the current state of the reproductive healthcare system for minors in the region.

Materials and methods . To assess the reproductive healthcare system, statistical data from the Medical Information and Analytical Center of the NR for 2019–2022 were used. To evaluate the characteristics of reproductive and somatic health, a clinical study with the participation of 127 adolescent girls seeking medical consultation at the Clinical Center for Family Health Care and Reproduction in 2019–2020 was conducted.

Results. The structure of the reproductive healthcare system for minors in the NR provides access to medical care via outpatient and inpatient settings, including specialized offi ces in the network of antenatal clinics, pediatric clinics and multi-fi eld hospitals. Developing routes for the referral of girls with gynecological diseases to medical organizations of various levels in the regions of the Siberian Federal District by 2022 and the annual analysis of service delivery show the availability and diversity of medical care to the children’s population in Novosibirsk and the NR. There was a decrease in the coverage of periodic health examinations for minors, as well as a sharp increase in cases of gynecological diseases among girls with disabilities. Non-infl ammatory diseases prevail in children under 10 years of age, and menstrual disorders – in adolescents. The provision of medical care and surgical treatment of gynecological diseases of adolescents is performed eff ectively, mainly using laparoscopic access. There has been an increase in requests for advice on contraception and sexual behavior, as well as an increase in the use of emergency contraception. A study conducted among adolescent girls revealed low adherence to contraception and a high incidence of menstrual dysfunction. The structure of extragenital pathology is dominated by diseases of the endocrine system, primarily obesity and thyroid disorders. Chronic otorhinolaryngologic, gastrointestinal and hematologic diseases also have an impact on the health of adolescents.

Conclusion. The data obtained indicate the need for further close attention to the reproductive health of minors, including developing eff ective measures for prevention and medical support.

Introduction. Diabetes mellitus (DM) is characterized by a high rate of growth in the number of patients which lead to their consumption of medicines. A pharmacogeographic approach makes it possible to predict an increase in the volume of drug consumption by patients with DM, considering not only the prevalence of DM, but also the existing environmental conditions, for example, in the Novosibirsk Region (NR). A i m . To perform a pharmacogeographic analysis of the relationship between environmental factors, diabetes prevalence and drug consumption by patients with DM in the NR.

Materials and methods. Statistical data from offi cial sources (Ministry of Health of the NR, Novosiboblfarm, Novosibirsk State Statistics Service, Ministry of Economic Development of the NR). Content analysis, comparative, factorial and correlation analysis, as well as methods of induction and deduction, synthesis, abstraction, grouping method, Sturges method were used.

Results. It was revealed that medical and demographic environmental factors have a noticeable eff ect on the volume of drug consumption by patients with DM. A regression model was obtained refl ecting the linear relationship between the indicator “volume of drug consumption by patients with DM, packages”, the prevalence of DM and indicators of medical and demographic environmental factors. A typology of the municipalities of the NR was carried out based on the combined infl uence of medical and demographic environmental factors, and the prevalence of DM on the volume of drug consumption by patients with diabetes.

Conclusion. The results of the pharmacogeographic analysis showed that the volume of drug consumption by DM patients in the NR is in direct linear relationship not only with the prevalence of DM, but also with a complex set of environmental factors, the most important among which are medical and demographic ones.

Introduction. A great success of modern oncohematology is the achievement of remission with timely initiation of chemotherapy regimen in 80–85% of patients with Hodgkin lymphoma (HL). However, the problem of the occurrence of severe therapy-related toxic complications of specifi c therapy in this group of patients remains relevant. MicroRNAs (miRs) aff ect the maturation and diff erentiation of mesenchymal cells, including bone marrow cells, can play a key role in the activity of normal hematopoiesis and hematopoietic tumors, and also regulate the activity of gene metabolism of anticancer drugs.

Aim. To determine the relationship between the miRNA expression in tumor biopsy samples of lymph nodes in patients with HL at the onset of the disease and the development of hematological toxicity during chemotherapy.

Materials and methods. In accordance with the Common Terminology Criteria for Adverse Events v5.0, hematological toxicity was assessed in 40 patients with HL treated with the ABVD (n = 13) and BEACOPP (n = 27) chemotherapy regimens. The real-time polymerase chain reaction was used to determine the expression of 20 miRNAs in tumor biopsy samples of lymph nodes in all patients with HL before chemotherapy and in histological preparations of patients (n = 40) with reactive lymphadenopathy (RL) as a control group.

Results. Toxic myelosuppression increased from the 1st to the 6th cycle of chemotherapy in patients treated with both the ABVD and BEACOPP regimens (p < 0.05). At the same time, grade 3–4 hematological toxicity in patients with HL treated with the BEACOPP regimen occurred 3 times more often than in patients with ABVD (p < 0.05), which indicates greater toxicity of the BEACOPP regimen. Overexpression of let-7c-5p, miR-185-5p and miR-128-3p positively correlates with the development of moderate and severe anemia (p < 0.05) in patients with HL after chemotherapy, suppressing the processes of maturation and diff erentiation of bone marrow cells, as well as activating their apoptosis.

Conclusion. Determining the miRNA expression as molecular genetic predictors of the development of chemotherapy-related organ toxicity in patients with HL will help achieve appropriate treatment results, reducing the risks of adverse eff ects and maintaining a high quality of life for patients after chemotherapy.

Introduction. The emergence of new strains of the SARS-CoV-2 virus and an increase in the number of cases around the world requires further study of the epidemiology, clinical peculiarities of the course and complications of this disease.

Aim. Revealing the characteristic of spread, clinical picture and signifi cance of clinical manifestations of a novel coronavirus infection in outpatients.

Materials and methods . An analysis was carried out of 387 outpatient records of children with confi rmed coronavirus infection (COVID-19) (group 1), as well as records of 9 children followed-up by a cardiologist for pericarditis with eff usion who had previously had coronavirus infection or positive results of a rapid test for coronavirus infection (group 2).

Results. When identifying possible sources of infection, we have found that half of the children in group 1 became got infected through contacts with members of their family. In 345 children (89.1%) of group 1, a rise in body temperature was noted, and mild systemic intoxication syndromes were observed in 316 children (81.7%). Gastrointestinal manifestations had 81 (21%) patients, skin syndrome such as exanthema on the trunk and limbs – only 20 (5%) patients, hemorrhagic events such as nosebleeds – 5 (1.3%) patients. Patients of group 2 had more pronounced systemic intoxication with a predominant neurotoxic eff ect.

Conclusion. The most common route of COVID-19 infection for children was intrafamilial transmission. Older children tolerated the infection more easily. The most common manifestations were fever, nonproductive cough, and signs of intoxication (myalgia, nausea, weakness). In complete blood count, neutropenia with lymphomonocytosis was a common fi nding. A complicated course occurred in 9 children with diagnosed pericarditis with eff usion.

Introduction. Hydrophilic antioxidants are quite attractive for use in biology, veterinary practice and medicine because of their high bioavailability and transport rates, convenience of administration and dosing, suitable for use in infusion therapy in acute conditions. Traditional use of phenolic antioxidants did not presuppose their hydrophilic properties; rather, lipophilicity was preferred. In this regard, it is not surprising that the number of known water-soluble forms of phenolic antioxidants is very limited.

Aim. Quantitative determination of the water-soluble antioxidant TF-7 substance by stripping voltam metry. Materials and methods. An object of the study was a new pharmaceutical substance of the water-soluble antioxidant TF-7 (3-(4-hydroxy-3,5-dimethylbenzylthio) potassium propionate). For quantitative determination, stripping voltammetry was used.

Results. The main parameters of the method, in particular sweep rate, time and potential of accumulation, which have the greatest infl uence on the quantitative characteristics of the analytical signal, were determined. The dependence of amount of the substance on concentration and the minimum detectable concentration are established. Optimal background electrolytes were selected, on which the analytical signal appears. Assessment of linearity showed the coeffi cient of linearity for the method developed was 0.997.

Conclusion. The selected parameters (background electrolyte, working electrode and reference electrode, accumulation potential and time, start and rate of sweep, mixing time) make it possible to quantify the water-soluble antioxidant TF-7 substance.

Introduction. Over the past decades, obstetrics around the world has faced an urgent problem – a signifi cant increase in the prevalence of cesarean sections (CS). In Russia, the proportion of this surgical procedure in the structure of childbirths is steadily increasing. Today, reducing the proportion of CS is considered one of the priorities of the Ministry of Health of the Russian Federation, healthcare offi cials of obstetric facilities of the Russian Federation, obstetricians-gynecologists of maternity departments at all levels.

Aim . A retrospective analysis of maternal records of patients in the Maternity Department of the Regional Perinatal Center (State Novosibirsk Regional Clinical Hospital) for July 2022 using the Robson’s ten group classifi cation system to fi nd possible ways to reduce the frequency of CS in a tertiary obstetric hospital. Materials and methods. The retrospective analysis of 387 maternal records of patients at the Maternity Department of the Regional Perinatal Center (State Novosibirsk Regional Clinical Hospital) in 2022 using the Robson’s ten group classifi cation system.

Results. The groups with the maximal and minimal impact on the overall frequency of CS in the tertiary obstetric hospital were identifi ed. In the structure of indications for CS, the most numerous was the group 5a, i.e. every fi fth delivery occurred in patients with at least one previous CS. Subject to a number of conditions, in accordance with current clinical guidelines and a professional approach to the management of labor with one previous CS, ensuring safe delivery, it is possible to expand the indications for vaginal delivery in patients with some relative contraindications. Groups 2b and 4b – women previously delivered by CS – have a signifi cant impact on the overall frequency of CS, which is associated with changes in the management tactics of high-risk pregnant women. Reducing the number of CS in these groups is possible only through more careful selection of pregnant women for programmed labor, the use of labor induction methods and rational interdisciplinary management of pathological labor. Group 10 (<37 weeks gestation patients) turned out to be signifi cant. According to current protocols for the management of preterm birth for this group, it is necessary to hold a case conference to clarify the term and mode of delivery, taking into account the gestational age, obstetric state, as well as current clinical protocols.

Conclusion. The main reserves for reducing abdominal delivery are groups 5a, 2b, 4b and 10 according to the Robson’s ten group classifi cation system. Expanding the indications for spontaneous labor in patients with previous CS is the main reserve for reducing the proportion of CS. Preterm birth currently does not always involve abdominal delivery. The Robson’s ten group classifi cation system is a robust tool for analyzing the frequency and structure of abdominal deliveries and identifying possible ways to reduce it.

Introduction. Heart transplantation is currently the mainstay of treatment for the end-stage chronic heart failure patients. To date, there is no consensus on the time criteria for cold ischemia of the donor heart. Despite a large number of studies, the question about the level of damage of cardiomyocyte cytoskeleton proteins at diff erent terms of cold ischemia remains unresolved; there is no clear time limit of acceptable preservation time and corresponding pathomorphological data on the state of their structure at ischemic and reperfusion damage.

Aim. An analysis of pathomorphological characteristics of cardiomyocytes and the expression of E-cadherin, protein from the family of cell adhesion molecules in the myocardium of the donor heart at diff erent terms of cold ischemia.

Materials and methods. Intraoperative biopsies of the myocardium of the left atrial appendage of donors aged up to 60 years after cold ischemia with Custodiol solution duration up to 240 min (group 1, n = 10) and over 240 min (group 2, n = 7) were used. Histological sections of the myocardium were stained according to the standard procedure with hematoxylin and eosin. Their further study was carried out by light microscopy, and to assess the E-cadherin expression immunohistochemistry was used.

Results. The assessment of cardiomyocyte pathomorphology under conditions of diff erent duration of myocardial cold ischemia revealed homogeneity and reversibility of changes in cellular structures, steady-state expression of the cell adhesion protein, E-cadherin at the sites of intercalated discs in patients of both groups.

Conclusion. The results showed that the activity of E-cadherin under cold myocardial ischemia with Custodiol solution for 240 min and over 240 min remains in steady-state, indicating the preservation its macromolecular structure and functional polarity of myocardial muscle cells.

This literature review presents available information on the possible ways in which the SARS-CoV-2 virus and the novel coronavirus infection (COVID-19) aff ect the female reproductive system. The putative mechanisms of the impact of SARSCoV-2 on the uterine mucosa and the possible contribution of the virus to the development of endometrial hyperplasia are described.

Pudendal neuropathia is a rare disease caused by entrapment or compression of the pudendal nerve in various anatomical structures. Pudendal neuropathia impacts the quality of patients’ life signifi cantly, and restricts the activities of daily living dramatically. The diagnosis of pudendal neuropathia is often made lately or wrongly because clinical manifestations can mimic other pathologies. Currently, there is a paucity of medical literature and scientifi c data on the diagnosis and treatment of this condition. This article presents a case of pudendal neuropathia in a man with pelvic pain complaints over a period of 6 months.