To improve the treatment of bacterial vaginosis and to extend the recurrence-free period, we examined 81 women of reproductive age (18–45 years) with a confirmed diagnosis of bacterial vaginosis. All patients were divided into 2 groups depending on the sensitivity of pathogens to the preparation of polyvalent bacteriophages (phagogine): group I included patients with low sensitivity to phagogine (n = 41) who took a combined drug with antimicrobial, antifungal and antiinflammatory effects (elzhina); patients of group II with high sensitivity to phagogine (n = 40) received combined therapy: elzhina + phagogine. The sensitivity of pathogens was determined by the bacteriological method. The greatest effectiveness (97.5% in group II versus 82.9% in group I) was shown by complex treatment (elzhina + phagogine).

Conflict of interest. The authors declare no conflict of interest.

In the research on the assessment of nutritional status in individuals with arterial hypertension (AH) as part of a dietitian appointment from the Health Center 54 patients with AH took part (mean age 57.63 ± 11.87). The control group consisted of 27 conditionally healthy patients.

It was analyzed anthropometric parameters (body weight, height, waist circumference (WC), hip circumference (HC)); an assessment of the component composition of the body and the actual nutrition was performed. In the group of hypertensive patients in comparison with the control group higher values of body mass index were found (overweight and obesity of the I–III degrees), waist-to-hip ratio (WHR), as well as body fat mass normalized by height (34.15 ± 12.00 in patients with AH versus 27.37 ± 11.17 in the control group). An analysis of laboratory parameters revealed a disturbance of lipid metabolism in the group of patients with AH. In the analysis of actual nutrition in people with AH, the signs of an unbalanced diet for macro- and micronutrients are observed mainly due to an excess of total fat by 29.26%, sodium — by 4.21%, cholesterol — by 8.27%, total carbohydrates — by 6.65%, added sugar — by 17.34% and saturated fatty acids — by 22.24% of the recommended intake against the background of a deficit in dietary fibers — by 61.15%, n-3 polyunsaturated fatty acids — by 14.32%, trace substances (calcium, magnesium) and vitamins (vitamin A, B vitamins, niacin).

Conflict of interest. The authors declare no conflict of interest.

Retrospective assessment of results of pathoanatomical researches on the deceased patients with community-acquired pneumonia treated in City Clinical Hospital No. 1 (Novosibirsk) in 2016–2018 is carried out for the purpose of studying gender, age features, etiology, clinical-morphological forms of the community-acquired pneumonia which resulted in lethal outcome. Morphological and bacteriological researches of lung samples in deceased patients with the diagnosis of pneumonia were conducted.

It is revealed that lethal outcomes owing to community-acquired pneumonia were more often observed in men, than in women, at advanced and senile age (56–67%). The rate of lethal outcomes owing to community-acquired pneumonia among all number of pathoanatomical thanatopsy made 2.6–3.8%. Lethality within the period of 24 hours of hospitalization was registered in 15–32% of cases. The divergence of clinical and pathoanatomical diagnoses reached 17.6%. Klebsiella pneumoniaе, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and also mixed-strain infection were the most widespread verifi ed causative agents of community-acquired pneumonia. The main clinical-morphological form of community-acquired pneumonia was the widespread bronchial pneumonia (purulent, with abscessing) (up to 87.8%) which did not present specifi c morphological picture depending on a type of the causative agent.

Conflict of interest. The authors declare no conflict of interest.

The study of the immune status of often and long-term sick children (OSC) — residents of the Altai Territory, involved 31 male and female children aged 3 to 5 years. All children were followed-up at the children’s clinic at the place of residence as “often sick,” suffering from recurrent respiratory diseases of the upper respiratory tract. The control group consisted of 28 conditionally healthy children aged 3–5 years who were not registered as often sick. All participants underwent a comprehensive clinical and laboratory examination, including a complete blood count, a study of biochemical blood parameters, a comprehensive immunological examination, a comprehensive parasite screening, an examination on herpes virus infections (human papillomavirus, Epstein — Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus (HSV)).

The analysis of microfl ora from the mucosa of the nasal cavity and pharynx revealed both opportunistic and pathogenic microfl ora in the group of OSC. Staphylococcus (S.) epidermidis (in 32% of children), Neisseria spp. (in 23%), S. aureus (in 15%) were most often found. 60% of OSC had a positive antibody (AB) response to EA (IgG) and VCA (IgG) antigens of EBV, as well as positive anti-CMV IgG. The analysis showed that AB to HSV were not detected in isolation from AB to other herpes viruses (EBV, CMV), while AB to CMV were found in 25% of cases, and AB to EBV — in 15%. The remaining 60% of cases accounted for their combination. An immunological examination of children did not reveal pronounced disorders of the immunological status, but there was an apparent decrease in the number of mature T-lymphocytes (CD3+), T-helper cells (CD4+), as well as T-cytotoxic lymphocytes (CD8+). Assessment of interferon (IFN) status revealed a relatively low level of IFN-α in the OSC. Thus, the majority of examined OSC did not have signifi cant disorders of the immune system, which requires local pediatricians to take a more balanced approach to the tactics of their examination.

Conflict of interest. The authors declare no conflict of interest.

It was conducted an examination of 210 adolescents of both sexes aged from 15 to 19 years old in three different types of educational institutions (school, gymnasium, university). It was also provided the research of life priorities of adolescents, of connection of Internet addiction disorder with subjective value of their feeling of happiness, of an existence of the life goal. The research included psychological interviewing, the use of the tests and the questionnaire. Special attention was paid on the vision by adolescents of their future, of the choice of a further course of their life with the respect to education, vocational guidance, the planned purposes and the ways of their achievements. It was revealed that the gymnasium pupils, the schoolboys and the students abusing the Internet have low ability for their understanding of their own psychological states, of the difficulties connected by the life goals, and of the rational organization of all social behavior.

Conflict of interest. The authors declare no conflict of interest.

The article considers the methodology for assessing the effectiveness of the quality system in a pharmacy organization, developed on the basis of the process approach and the method of criteria indicators. The results of testing the methodology on the example of a specific pharmacy organization are presented.

Conflict of interest. The authors declare no conflict of interest.

Currently relevant is the study of molecular biological factors that play a role in the prognosis of breast cancer (BC). Of great interest is the analysis of the transcription factors GATА₃, FOXA₁, ELF₅ involved in differentiation of the mammary gland epithelium, as well as in the pathogenesis of BC and the mechanisms of tumor progression.

101 patients (age from 30 years to 81 years, mean age 54.9 ± 10.4 years) with breast carcinoma (T_1–4N_1–3M₀) participated in the study of transcription factors expression depending on clinical and morphological characteristics of BC. Inclusion criteria: luminal breast cancer, no preoperative treatment. The exclusion criterion is stage IV disease. The expression characteristics of the studied markers in the context of different clinical and morphological parameters of the neoplasm node were analyzed. Negative expression of ELF5 was found to be associated with a large tumor size. Expression of GATА₃, FOXA₁ is lower in patients with negative expression to progesterone receptors. The pronounced expression of ELF₅ is associated with the phenomenon of retraction. The character of expression of the studied markers is associated with the development of lymphogenic metastasis.

Thus, the expression characteristics of GATА₃, FOXA₁ and ELF₅ may be useful as additional prognostic factors used to assess the risk of lymphogenic metastasis.

Conflict of interest. The authors declare no conflict of interest.

In scleral flaps resected during anti-glaucoma surgeries in 60 patients with 6 different forms of primary glaucoma, the content of connective tissue cells — matrix-producing and infi ltrate elements — was studied using comparative morphometric analysis. The scoring of the proximal and distal sclera zones separately with 2 forms of glaucoma with a pretrabular level of the hydrodynamic block revealed a signifi cantly higher number of matrix-producing cells in congenital glaucoma compared with angle-closure one. Analysis of 4 forms of glaucoma with a trabecular block showed a significantly higher content of matrix-producing cells up to the distal drainage pathways in pigmentary and pseudoexfoliation glaucoma which contributes to the development of accelerated retention of the aqueous humor outflow. The polymorphic pattern of structural changes in the connective tissue of the eye drainage system determines the feasibility of using a differentiated algorithm when planning the surgical treatment volume.

In order to assess the psychoemotional state of children and adolescents with dermatological pathology with excess body weight and obesity, a study was performed using the Luscher color test among 270 children and adolescents aged 5–17 years with various dermatological pathologies and overweight or obesity. The control group consisted of 270 patients with a similar skin pathology, but with a body weight corresponding to the age and gender norms.

In general, the emotional state of children and adolescents of the main group, compared with patients in the control group, was 4.3 times more likely to be assessed as unsatisfactory (2 points) or as crisis (1 point), and a favorable emotional state (3–4 points) was recorded in them 2.8 times less often than in the control group. In the main group, the psychoemotional state in 5–6 year-old children in most cases did not cause concern: 78.9% of them scored 3–4 points. In the old groups, the situation was another: only 61% in 7–11 year-old children and only 53.6% — in 12–17 year-old ones scored 3–4 points. Differences in test results between boys and girls were registered. As the degree of obesity increased, the proportion of patients with an unsatisfactory or crisis emotional state increased from 15.4% with overweight to 38.8, 70.9 and 77.4% respectively, with obesity of I, II and III degrees. Among patients with two or more dermatological pathologies, the number of children and adolescents who scored 1–2 points during testing was 2.1 times higher than the same indicator in the group with one skin disease.

Conflict of interest. The authors declare no conflict of interest.

The aim of the study was to develop a method for predicting the development of stroke in men working under conditions of exposure to general vibration. The survey included 134 men aged 30 to 65 years, who worked 5 or more years by occupation: truck driver (BelAZ-75, general vibration level — 80–116 dB), bus driver (general vibration level — 75–101 dB). The study participants were divided into two groups: the fi rst — 70 men who had a stroke; the second — 64 men with a diagnosis of chronic cerebral ischemia.

Using the method of successive inclusion of variables (Forward Stepwise), the risk factors for stroke in the study group (age, work experience, total cholesterol, taking antihypertensive drugs, the presence of a history of smoking factor) were established and a logistic regression formula was proposed that allows to determine the probability of stroke development. A value equal to or greater than 0.6 obtained by calculation using this formula indicates a high risk of stroke development. The sensitivity of the proposed method was 81.4%, specifi city — 76.6%. The proposed method for predicting the development of stroke in men working under conditions of exposure to general vibration can be used during preventive and periodic medical examinations.

Conflict of interest. The authors declare no conflict of interest.

An application No. 2019116922 has been submitted to Rospatent. Priority date is 31.05.2019.

The open single center retrospective study of 418 case histories of children who were observed with pertussis infection in Novosibirsk Children’s City Clinical Hospital No. 3 was conducted. The objective of the research was to study characteristics of the course of pertussis infection complicated by pneumonia and to identify probable risk factors, as well as clinical laboratory predictors, ways of prevention of the pertussis complicated by pneumonia.

The analysis of the received results showed that absence of vaccination, the burdened comorbid background and the artificial feeding being the probable risk factors of the complicated pertussis, moreover, the combination of the above mentioned factors results in the high frequency of development of pertussis-associated pneumonia. The significant increase in frequency of cough, the rise in leukocytosis, neutrocytosis in the course of pertussis should be considered as predictors of the developing pneumonia. Vaccination is an adequate method of prevention of the pertussis infection complicated by pneumonia.

Conflict of interest. The authors declare no conflict of interest.